Results 71 to 80 of about 4,849,377 (223)

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Paf-Metabolic Enzymes and Paf-like Activity in and Promastigotes

European Journal of Inflammation, 2011
Leishmania spp are obligate intracellular protozoan parasites of the mononuclear phagocyte system that cause a spectrum of diseases known as leishmaniasis.
P. Chatzovoulos, A.B. Tsoupras, M. Samiotaki, G. Panayotou, C.A. Demopoulos, E. Dotsika   +5 more
doaj   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

Endosomes, Glycosomes, and Glycosylphosphatidylinositol Catabolism in Leishmania major [PDF]

Journal of Biological Chemistry, 2004
Glycosylphosphatidylinositols (GPIs) serve as membrane anchors of polysaccharides and proteins in the protozoan parasite Leishmania major. Free GPIs that are not attached to macromolecules are present in L. major as intermediates of protein-GPI and polysaccharide-GPI synthesis or as terminal glycolipids.
Zhifeng, Zheng, Kimberly D, Butler, Rodney K, Tweten, Kojo, Mensa-Wilmot   +3 more
openaire   +2 more sources

Comparison of Protein Profile of Killed and Autoclaved Leishmania Major Using Polyacrylamide Gel Electrophoresis

مجله دانشکده پزشکی اصفهان, 2013
Background: Leishmania is a genus of trypanosomatid protozoa which causes a wide spectrum of diseases ranging from a self-healing cutaneous lesion to a vital visceral form of the disease.
Reza Arjmand, Simindokht Soleimanifard, Sedigheh Saberi, Sepideh Tolouei, Ali Khamesipour, Seyed Hossein Hejazi   +5 more
doaj  

Systemic treatment of cutaneous leishmaniasis: A systematic review and meta‐analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This systematic review and meta‐analysis assessed systemic treatments for cutaneous leishmaniasis across 83 studies and 4603 patients. Treatment efficacies of meglumine antimoniate, miltefosine, azoles, pentamidine, and liposomal amphotericin B varied by region and species. Miltefosine showed consistent evidence across multiple settings.
Maximilian Egg, Dennis Wienand, Lucie Harpain, Marie‐Luise Brunner‐Kovarik, Julia Walochnik, Markus Wiesmueller, Amélie Hampel, Tibor Spath, Lukas Trnka, Judit Simon, Alessandra Handisurya   +10 more
wiley   +1 more source

Evaluation of methylene blue as photosensitizer in promastigotes of Leishmania major and Leishmania braziliensis

Photodiagnosis and Photodynamic Therapy, 2017
The cutaneous leishmaniasis is caused by the protozoan of the genus Leishmania. It is considered by WHO as a public health issue and a neglected disease, which affects rural workers and it is also a risk to travelers in endemic areas. The conventional treatment is toxic and leads to severe side effects.
Juliana Guerra, Pinto, Jaciara Fagundes de Souza, Martins, André Henrique Correia, Pereira, Josane, Mittmann, Leandro José, Raniero, Juliana, Ferreira-Strixino   +5 more
openaire   +2 more sources

Oligopeptidase B deficient mutants of Leishmania major [PDF]

Molecular and Biochemical Parasitology, 2011
Oligopeptidase B is a clan SC, family S9 serine peptidase found in gram positive bacteria, plants and trypanosomatids. Evidence suggests it is a virulence factor and thus therapeutic target in both Trypanosoma cruzi and T. brucei, but little is known about its function in Leishmania. In this study L.
Munday, Jane C., McLuskey, Karen, Brown, Elaine, Coombs, Graham H, Mottram, Jeremy C   +4 more
openaire   +4 more sources

Super Infection of Cutaneous Leishmaniasis Caused by Leishmania major and L. tropica to Crithidia fasciculata in Shiraz, Iran

Iranian Journal of Public Health, 2019
Background: The aims of the current study were to determined present status of CL in Shiraz City, identify the causative species of Leishmania and conduct phylogenetic evaluations in detected parasites Methods: This study was conducted on 70 ...
Aliyar MIRZAPOUR, Alireza BADIRZADEH, Marzieh ASHRAFMANSOURI, Hamed BEHNIAFAR, Maryam NOROUZI, Hakim AZIZI, Mahmoodreza BEHRAVAN, Seyyed Javad SEYYED TABAEI   +7 more
doaj   +1 more source

Retrospective evaluation of outcomes in dogs with non‐associative immune‐mediated haemolytic anaemia treated with rivaroxaban as a sole or adjunctive thromboprophylaxis agent: 34 cases (2018‐2024)

Journal of Small Animal Practice, EarlyView.
Objectives To describe clinical outcomes, thromboembolic and haemorrhagic complications, and treatment characteristics in dogs with non‐associative immune‐mediated haemolytic anaemia treated with rivaroxaban at a UK referral hospital. Materials and Methods Retrospective descriptive study of dogs diagnosed with non‐associative immune‐mediated haemolytic
S. Conway, L. Jenkins, J. Reeve
wiley   +1 more source