Results 131 to 140 of about 7,407 (178)
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Phosphomonoesterases of Leishmania mexicana mexicana and other flagellates
Molecular and Biochemical Parasitology, 1987Amastigotes and log-phase promastigotes of Leishmania mexicana mexicana contained distinct acid phosphatase, 3'-nucleotidase and 5'-nucleotidase activities, distinguishable by their response to pH and inhibitors. Both tartrate-sensitive and tartrate-resistant acid phosphatase were present in the two forms, amastigotes possessed less tartrate-resistant ...
H F, Hassan, G H, Coombs
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Mastomys natalensis as an experimental host for Leishmania mexicana mexicana
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1978Young multimammate rats (Mastomys natalensis) can be readily infected when inoculated intradermally with the amastigotes of Leishmania mexicana mexicana. Lesions appear at the site of inoculation in the second week of infection and continue to increase in size for the first month; amastigotes can be detected during this period.
L H, Pereira +6 more
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Sterols of ketoconazole-inhibited Leishmania mexicana mexicana promastigotes
Molecular and Biochemical Parasitology, 1985Leishmania mexicana mexicana promastigotes grown with cholesterol, supplied in natural products as the free sterol and as cholesteryl esters, were exposed to [2-14C]mevalonate and to the antimycotic drug ketoconazole. Growth was inhibited and cholesterol and 14 alpha-methyl sterols accumulated in free and esterified forms (cholesterol much greater than
L J, Goad, G G, Holz, D H, Beach
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Glucose transport in amastigotes and promastigotes of Leishmania mexicana mexicana
Molecular and Biochemical Parasitology, 1995Promastigotes and amastigotes of Leishmania mexicana mexicana transported 2-deoxy-D-glucose (2-DOG) by a saturable process with a Km of 24 +/- 3 microM and Vmax of 2.21 nmol min-1 (mg protein)-1 for the promastigote and a Km of 29 +/- 8 microM and Vmax of 0.13 nmol min-1 (mg protein)-1 for the amastigote stage.
R J, Burchmore, D T, Hart
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Leishmania tropica and Leishmania mexicana: Cross-immunity in mice
Experimental Parasitology, 1978Abstract The effect of a previous or concurrent Leishmania tropica major infection on a L. mexicana infection was studied. Mice which were recovering from or had recovered from a L. tropica infection were found to be totally resistant to L. mexicana. Infection of mice already carrying a L. mexicana infection with L.
J, Alexander, R S, Phillips
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The Leishmania mexicana proteasome
Molecular and Biochemical Parasitology, 1999As a start to understanding the importance of intracellular proteolysis in the protozoon Leishmania mexicana, the parasite proteasome has been purified and characterised. The L. mexicana proteasome is similar to proteasomes from other eukaryotes. It is soluble, and the 20S form has a mass of around 670 kDa, composed of at least 10 distinct subunits in ...
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Subcellular localisation of purinemetabolising enzymes in Leishmania mexicana mexicana
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1985Leishmania mexicana mexicana cultured promastigotes were fractionated by isopycnic centrifugation on linear sucrose gradients. Guanine, hypoxanthine and xanthine phosphoribosyltransferase activities were found to be associated with glycosomes, whereas adenine phosphoribosyltransferase was cytosolic.
H F, Hassan, J C, Mottram, G H, Coombs
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Respiration of Leishmania mexicana amastigotes and promastigotes
Molecular and Biochemical Parasitology, 1981Promastigotes of Leishmania mexicana mexicana recently derived from amastigotes by transformation in vitro respired at a rate (17 nmol O2/min per 10(8) parasites) 4-5 times higher than that of amastigotes, but when the difference in cell protein content between the two preparations was taken into account the rates were not significantly different (32 ...
D T, Hart, K, Vickerman, G H, Coombs
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Pentose phosphate metabolism in Leishmania mexicana
Molecular and Biochemical Parasitology, 2003The metabolism of pentose phosphates was studied in Leishmania mexicana promastigotes. Each of the enzymes of the classical pentose phosphate pathway (PPP) has been identified and specific activities measured. Functioning of the PPP was demonstrated in non-growing cells by measuring the evolution of 14CO2 from [1-14C]D-glucose and [6-14C]D-glucose ...
Dante Abel, Maugeri +4 more
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Chromosome rearrangement in Leishmania mexicana M379
Molecular and Biochemical Parasitology, 1991Circular extrachromosomal elements were observed in a variety of Leishmania species. We show here that two lines originating from the same isolate have been found to contain a circular DNA molecule of 26.6 kb and a linear chromosome of about 250 kb, respectively, which share a homology of more than 20 kb.
Liu, J. +9 more
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