Results 171 to 180 of about 4,221 (205)
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Molecular and Biochemical Parasitology, 1985
The inability to synthesize heme, a well known metabolic defect of trypanosomatid protozoa, accounts for their growth requirement for heme compounds in vitro. We now extend this finding to a pathogen Leishmania mexicana amazonensis, especially the intracellular replicative stage of amastigotes in the macrophage.
C S, Chang, K P, Chang
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The inability to synthesize heme, a well known metabolic defect of trypanosomatid protozoa, accounts for their growth requirement for heme compounds in vitro. We now extend this finding to a pathogen Leishmania mexicana amazonensis, especially the intracellular replicative stage of amastigotes in the macrophage.
C S, Chang, K P, Chang
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Uptake and killing ofLeishmania mexicana amazonensisamastigotes by human skin fibroblasts
Annals of Tropical Medicine & Parasitology, 1983This paper describes the in vitro infection of human established fibroblast lines by Leishmania mexicana amazonensis amastigotes. Intracellular parasites were located within vacuoles. The proportion of infected cells reached a peak of about 50% on Days 2 or 3, and decreased to almost 0 on Days 6 or 8.
J P, Dedet +4 more
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Parasitology Research, 1987
Significant differences were found in the ability of resident mouse peritoneal macrophages to ingest amastigote and promastigote forms of Leishmania mexicana amazonensis. Differences in the association index of the parasites to the macrophages were also found between infective and non-infective promastigotes.
E M, Saraiva, A F, Andrade, W, de Souza
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Significant differences were found in the ability of resident mouse peritoneal macrophages to ingest amastigote and promastigote forms of Leishmania mexicana amazonensis. Differences in the association index of the parasites to the macrophages were also found between infective and non-infective promastigotes.
E M, Saraiva, A F, Andrade, W, de Souza
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Annals of Tropical Medicine & Parasitology, 1982
Ultrastructural observations showed that pentamidine isethionate causes disruption of the mitochondrion of Leishmania mexicana amazonensis promastigotes and amastigotes in vitro at 25 and 32°C, respectively. The distension and loss of structure of the mitochondrion was followed by the disruption and condensation of the kinetoplast.
S L, Croft, R P, Brazil
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Ultrastructural observations showed that pentamidine isethionate causes disruption of the mitochondrion of Leishmania mexicana amazonensis promastigotes and amastigotes in vitro at 25 and 32°C, respectively. The distension and loss of structure of the mitochondrion was followed by the disruption and condensation of the kinetoplast.
S L, Croft, R P, Brazil
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Effects of temperature elevation on mRNA and protein synthesis in Leishmania mexicana amazonensis
Molecular and Biochemical Parasitology, 1988The transition from the promastigote stage to the amastigote stage in Leishmania appears to involve a sequence of steps which enable the parasite to adapt to its new environment. In this study, transformation from the promastigote to an amastigote-like stage was induced by temperature elevation and the effects on protein synthesis and the mRNA ...
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Annales de l'Institut Pasteur / Immunologie, 1988
Attempts to develop a satisfactory vaccine against New World cutaneous leishmaniasis have been made with varying success. We found that in mice, pretreated subcutaneously with 2 X 10(6) BCG organisms 2 weeks prior to immunization at the same site with as low as 10 micrograms of a microsomal preparation (Pol-F) of Leishmania mexicana amazonensis, a ...
S, Goncalves da Costa +2 more
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Attempts to develop a satisfactory vaccine against New World cutaneous leishmaniasis have been made with varying success. We found that in mice, pretreated subcutaneously with 2 X 10(6) BCG organisms 2 weeks prior to immunization at the same site with as low as 10 micrograms of a microsomal preparation (Pol-F) of Leishmania mexicana amazonensis, a ...
S, Goncalves da Costa +2 more
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Archives of Biochemistry and Biophysics, 1993
Using phosphocellulose affinity chromatography we were able to separate two pyruvate kinase (EC 2.7.1.40) activities in the parasitic protozoan Leishmania mexicana amazonesis. One activity (PYK1) showed hyperbolic kinetics and was decreased by fructose 2,6-bisphosphate, whereas the second activity (PYK2) showed sigmoidal kinetics for the substrate ...
A, Ponte-Sucre +5 more
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Using phosphocellulose affinity chromatography we were able to separate two pyruvate kinase (EC 2.7.1.40) activities in the parasitic protozoan Leishmania mexicana amazonesis. One activity (PYK1) showed hyperbolic kinetics and was decreased by fructose 2,6-bisphosphate, whereas the second activity (PYK2) showed sigmoidal kinetics for the substrate ...
A, Ponte-Sucre +5 more
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Freeze-Fracture Study of the Plasma Membrane of Leishmania mexicana amazonensis
The Journal of Parasitology, 1980The fine structure of the plasma membrane of promastigotes of Leishmania mexicana amazonensis was studied by freeze-fracture techniques. Measurement of the number of intramembranous particles per square micrometer of membrane area revealed a particle density of 2,040 +/- 213/micron2 on the P-face and 890 +/- 186/micron2 on the E-face.
M, Benchimol, W, de Souza
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Annals of Tropical Medicine & Parasitology, 1985
(1985). The activity of plumbagin and other electron carriers against Leishmania donovani and Leishmania mexicana amazonensis. Annals of Tropical Medicine & Parasitology: Vol. 79, No. 6, pp. 651-653.
S L, Croft, A T, Evans, R A, Neal
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(1985). The activity of plumbagin and other electron carriers against Leishmania donovani and Leishmania mexicana amazonensis. Annals of Tropical Medicine & Parasitology: Vol. 79, No. 6, pp. 651-653.
S L, Croft, A T, Evans, R A, Neal
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Cytochemical localization of acid phosphatase in Leishmania mexicana amazonensis.
Journal of submicroscopic cytology, 1986Acid phosphatase was cytochemically detected at the ultrastructural level in infective and non-infective promastigotes and in amastigotes of the parasitic protozoan Leishmania mexicana amazonensis. Cerium chloride was used as the capture agent of the phosphate liberated during the hydrolysis of the substrate (Na-beta-glycerophosphate). Reaction product,
P F, Pimenta, W, De Souza
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