Results 171 to 180 of about 6,615 (212)
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Leishmania mexicana amazonensis: Surface charge of amastigote and promastigote forms
Experimental Parasitology, 1983The surface charge of Leishmania mexicana amazonensis was evaluated by means of the binding of colloidal iron hydroxyde particles at pH 1.8 and cationized ferritin particles at pH 7.2 to the cell surface, visualizated by electron microscopy and by direct measurements of the electrophoretic mobility of cells suspended in solutions of different pH.
P F, Pimenta, W, de Souza
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Experimental Parasitology, 1988
Leishmania mexicana amazonensis amastigotes were induced to differentiate by incubation at 27 C. Morphological transformation was studied both in untreated cultures and in cultures where DNA synthesis, and consequently the final stage in the production of promastigotes, was inhibited by hydroxyurea.
D R, Taylor, G T, Williams
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Leishmania mexicana amazonensis amastigotes were induced to differentiate by incubation at 27 C. Morphological transformation was studied both in untreated cultures and in cultures where DNA synthesis, and consequently the final stage in the production of promastigotes, was inhibited by hydroxyurea.
D R, Taylor, G T, Williams
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N-Glycosylation as a biochemical basis for virulence in Leishmania mexicana amazonensis
Molecular and Biochemical Parasitology, 1988Promastigotes of Leishmania mexicana amazonensis grown in vitro under different conditions showed variable degrees of virulence, as determined quantitatively by the size of the lesions and the number of intracellular parasites produced in mice and in cultured macrophages, respectively.
J A, Kink, K P, Chang
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Uptake and killing ofLeishmania mexicana amazonensisamastigotes by human skin fibroblasts
Annals of Tropical Medicine & Parasitology, 1983This paper describes the in vitro infection of human established fibroblast lines by Leishmania mexicana amazonensis amastigotes. Intracellular parasites were located within vacuoles. The proportion of infected cells reached a peak of about 50% on Days 2 or 3, and decreased to almost 0 on Days 6 or 8.
J P, Dedet +4 more
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Annals of Tropical Medicine & Parasitology, 1990
Imidazoles such as ketoconazole have proven antileishmanial activity, both in vitro and in vivo. New derivatives of ketoconazole have been synthesized in order to improve the therapeutic index and antileishmanial activity as assessed by mouse peritoneal macrophages infected with Leishmania mexicana amazonesis. Amino-acid derivatives of ketoconazole are
P, Pirson, B, Leclef, A, Trouet
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Imidazoles such as ketoconazole have proven antileishmanial activity, both in vitro and in vivo. New derivatives of ketoconazole have been synthesized in order to improve the therapeutic index and antileishmanial activity as assessed by mouse peritoneal macrophages infected with Leishmania mexicana amazonesis. Amino-acid derivatives of ketoconazole are
P, Pirson, B, Leclef, A, Trouet
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Molecular and Biochemical Parasitology, 1988
In order to understand the mechanisms which generate minicircle sequence diversity, we sequenced three minicircles belonging to the same or closely related sequence classes from the kinetoplast DNA of Leishmania mexicana amazonensis strains, PH8, Raimundo, and Josefa.
W O, Rogers, D F, Wirth
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In order to understand the mechanisms which generate minicircle sequence diversity, we sequenced three minicircles belonging to the same or closely related sequence classes from the kinetoplast DNA of Leishmania mexicana amazonensis strains, PH8, Raimundo, and Josefa.
W O, Rogers, D F, Wirth
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Archives of Biochemistry and Biophysics, 1993
Using phosphocellulose affinity chromatography we were able to separate two pyruvate kinase (EC 2.7.1.40) activities in the parasitic protozoan Leishmania mexicana amazonesis. One activity (PYK1) showed hyperbolic kinetics and was decreased by fructose 2,6-bisphosphate, whereas the second activity (PYK2) showed sigmoidal kinetics for the substrate ...
A, Ponte-Sucre +5 more
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Using phosphocellulose affinity chromatography we were able to separate two pyruvate kinase (EC 2.7.1.40) activities in the parasitic protozoan Leishmania mexicana amazonesis. One activity (PYK1) showed hyperbolic kinetics and was decreased by fructose 2,6-bisphosphate, whereas the second activity (PYK2) showed sigmoidal kinetics for the substrate ...
A, Ponte-Sucre +5 more
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Annales de l'Institut Pasteur / Immunologie, 1988
Attempts to develop a satisfactory vaccine against New World cutaneous leishmaniasis have been made with varying success. We found that in mice, pretreated subcutaneously with 2 X 10(6) BCG organisms 2 weeks prior to immunization at the same site with as low as 10 micrograms of a microsomal preparation (Pol-F) of Leishmania mexicana amazonensis, a ...
S, Goncalves da Costa +2 more
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Attempts to develop a satisfactory vaccine against New World cutaneous leishmaniasis have been made with varying success. We found that in mice, pretreated subcutaneously with 2 X 10(6) BCG organisms 2 weeks prior to immunization at the same site with as low as 10 micrograms of a microsomal preparation (Pol-F) of Leishmania mexicana amazonensis, a ...
S, Goncalves da Costa +2 more
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Molecular and Biochemical Parasitology, 1985
The inability to synthesize heme, a well known metabolic defect of trypanosomatid protozoa, accounts for their growth requirement for heme compounds in vitro. We now extend this finding to a pathogen Leishmania mexicana amazonensis, especially the intracellular replicative stage of amastigotes in the macrophage.
C S, Chang, K P, Chang
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The inability to synthesize heme, a well known metabolic defect of trypanosomatid protozoa, accounts for their growth requirement for heme compounds in vitro. We now extend this finding to a pathogen Leishmania mexicana amazonensis, especially the intracellular replicative stage of amastigotes in the macrophage.
C S, Chang, K P, Chang
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Annals of Tropical Medicine & Parasitology, 1985
(1985). The activity of plumbagin and other electron carriers against Leishmania donovani and Leishmania mexicana amazonensis. Annals of Tropical Medicine & Parasitology: Vol. 79, No. 6, pp. 651-653.
S L, Croft, A T, Evans, R A, Neal
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(1985). The activity of plumbagin and other electron carriers against Leishmania donovani and Leishmania mexicana amazonensis. Annals of Tropical Medicine & Parasitology: Vol. 79, No. 6, pp. 651-653.
S L, Croft, A T, Evans, R A, Neal
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