Results 61 to 70 of about 6,615 (212)

Leishmaniose cutânea na Amazônia: registro do primeiro caso humano de infecção mista, determinado por duas espécies distintas de Leishmnias: Leishmania brasiliensis e Leishmania mexicana amazonensis

open access: yesRevista do Instituto de Medicina Tropical de São Paulo, 1984
Fez-se o registro, na Amazônia, do primeiro caso humano de infecção cutânea mista determinada por duas espécies distintas de Leishmania: a Leishmania braziliensis braziliensis e a Leishmania mexicana amazonensis.
F. T. Silveira   +3 more
doaj   +1 more source

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

open access: yesChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral   +7 more
wiley   +1 more source

Immunocytochemical identification of leishmania and Trypanosoma cruzi amastigotes in situ with homologous and heterologous polyclonal antibodies

open access: yesRevista da Sociedade Brasileira de Medicina Tropical, 1991
The unlabelled antibody peroxidase-antiperoxidase method was used to study the immunocytochemical properties of Leishmania and Trypanosoma cruzi amastigotes in situ after tissues had been submitted to different fixation procedures. Antisera were obtained
A.J.A. Barbosa   +5 more
doaj   +3 more sources

How to master the host immune system? Leishmania parasites have the solutions! [PDF]

open access: yes, 2017
Infection by protozoan parasites of the genus Leishmania results in the development of leishmaniasis, an increasingly prevalent group of diseases affecting over 12 million people worldwide.
Fasel, N., Rossi, M.
core   +1 more source

Profiling Serine Hydrolases in the Leishmania Host–Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes

open access: yesChemBioChem, Volume 26, Issue 10, May 27, 2025.
Leishmaniasis poses a global health challenge with limited treatment options and rising drug resistance. Activity‐based protein profiling using fluorophosphonate probes is employed to profile serine hydrolases, key virulence factors in Leishmania mexicana.
Jaime A. Isern   +7 more
wiley   +1 more source

Ensayos metodologicos para la investigacion de reservorios de Leishmania spp en los Andes venezolanos Methodological assay for research of reservoirs of Leishmania spp. in the Venezuelan Andes

open access: yesMemorias do Instituto Oswaldo Cruz, 1982
Se describen dos técnicas, presuntiva y confirmativa, para la investigación de mamíferos que pudieran ser reservorios de Leishmania que parasitan al hombre.
Ana Lugo Yarbuh, J. V. Scorza
doaj   +1 more source

Mucocutaneous Leishmaniasis With Oral Involvement: A Case Report

open access: yesCase Reports in Dentistry, Volume 2025, Issue 1, 2025.
The primary objective of the present study is the retrospective analysis of a clinical case of oral leishmaniasis treated at Parma Hospital and a review of the literature on mucosal leishmaniasis (ML) with oral cavity involvement. We report the case of a patient diagnosed in 2017 with mucocutaneous leishmaniasis who was referred to our clinic due to ...
Pierpaolo De Francesco   +6 more
wiley   +1 more source

Leishmania vaccines entered in clinical trials: A review of literature

open access: yesInternational Journal of Preventive Medicine, 2019
Leishmaniasis is considered as a zoonotic infection and neglected tropical disease. Leishmania treatment is not totally successful and imposes high expenditures, especially in developing countries. Since the natural infection leads to the robust immunity
Mohammad Moafi   +3 more
doaj   +1 more source

Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition. [PDF]

open access: yes, 2010
A family of hydrophilic acylated surface (HASP) proteins, containing extensive and variant amino acid repeats, is expressed at the plasma membrane in infective extracellular (metacyclic) and intracellular (amastigote) stages of Old World Leishmania ...
Depledge, DP   +7 more
core  

Résultats préliminaires en faveur de l'existence d'un antigène majeur de surface, spécifique de LEISHMANIA BRAZILIENSIS BRAZILIENSIS [PDF]

open access: yes, 1986
L'Etude comparative des antigènes de surface de 10 souches boliviennes de référence de la sous-espèce L. B. Braziliensis a permis de mettre en évidence une grande homogénéité au sein de ce groupe.
Brenière, Simone Frédérique   +4 more
core  

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