Results 51 to 60 of about 689,681 (185)

Chicken blood provides a suitable meal for the sand fly Lutzomyia longipalpis and does not inhibit Leishmania development in the gut [PDF]

, 2010
Background The aim of this study was to address the role of chickens as bloodmeal sources for female Lutzomyia longipalpis and to test whether chicken blood is harmful to Leishmania parasite development within the sand flies.
Nascimento, Alexandre, Dilger, Erin, Cavalcante, Reginaldo R, Diaz-Albiter, Hector M, Alexander, Bruce, Dillon, Rod J, Sant'anna, Mauricio Rv, Bates, Paul A   +7 more
core   +3 more sources

Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB [PDF]

, 2013
Cysteine proteases of the papain superfamily are present in nearly all eukaryotes. They play pivotal roles in the biology of parasites and inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as sleeping
Mottram, Jeremy C, Coombs, Graham H, Schröder, Jörg, Marhöfer, Richard J, Noack, Sandra, Selzer, Paul M   +5 more
core   +4 more sources

MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana [PDF]

, 2010
In this study we generated a novel dual specific phosphatase 4 (DUSP4) deletion mouse using a targeted deletion strategy in order to examine the role of MAP kinase phosphatase-2 (MKP-2) in immune responses.
McGachy, H.A., Bryant, C.E., Cadalbert, L.C., Alexander, James, Schroeder, J., Shweash, M.S., Plevin, R.J., Kurnik, M., Sloss, C.M., Al-Mutairi, M.S.   +9 more
core   +3 more sources

Ensayos metodologicos para la investigacion de reservorios de Leishmania spp en los Andes venezolanos Methodological assay for research of reservoirs of Leishmania spp. in the Venezuelan Andes

Memorias do Instituto Oswaldo Cruz, 1982
Se describen dos técnicas, presuntiva y confirmativa, para la investigación de mamíferos que pudieran ser reservorios de Leishmania que parasitan al hombre.
Ana Lugo Yarbuh, J. V. Scorza
doaj   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

Leishmania vaccines entered in clinical trials: A review of literature

International Journal of Preventive Medicine, 2019
Leishmaniasis is considered as a zoonotic infection and neglected tropical disease. Leishmania treatment is not totally successful and imposes high expenditures, especially in developing countries. Since the natural infection leads to the robust immunity
Mohammad Moafi, Hossein Rezvan, Roya Sherkat, Roya Taleban   +3 more
doaj   +1 more source

In Situ Evaluation of Macrophage Populations and Inflammasome Components in Cutaneous and Mucocutaneous Leishmaniasis

Parasite Immunology, Volume 47, Issue 9, September 2025.
ABSTRACT American tegumentary leishmaniasis (ATL) affects the skin and mucous membranes, with a spectrum shaped by Th1/Th2 responses. This study investigated inflammasome activation in correlation with macrophage subpopulations, tissue parasitism, and histological changes in cutaneous and mucocutaneous leishmaniasis. We assessed inflammasome activation,
Caroline de Heleno Chagas de Carvalho, Gabriela Venicia Araujo Flores, Carmen Maria Sandoval Pacheco, Vania Lucia da Ribeiro da Matta, Carolina de Esteves de Morais, Ricardo Romiti, Walter Belda Júnior, Márcia Dalastra Laurenti   +7 more
wiley   +1 more source

Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis [PDF]

Antimicrobial Agents and Chemotherapy, 1990
The antiprotozoal compound 1,5-di(4-amidinophenoxy)pentane (pentamidine) and 36 of its analogs were screened for in vitro activity against Leishmania mexicana amazonensis clone 669 C4S (MHOM/BR/73/M2269) and Plasmodium falciparum clones W2 (Indochina III/CDC) and D6 (Sierra Leone I/CDC).
C A, Bell, J E, Hall, D E, Kyle, M, Grogl, K A, Ohemeng, M A, Allen, R R, Tidwell   +6 more
openaire   +2 more sources

Different Derivatives of Plumbagin Analogue: Bioavailability and Their Toxicity Studies

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Plumbagin, discovered in Plumbago zeylanica, has potential therapeutic effects such as anticancer, antimicrobial, and anti‐inflammatory characteristics. It has traditionally been used to treat anemia and rheumatic pain, but its therapeutic application is limited because of low bioavailability and toxicity risk factors.
Souparnika Thekkumkara, Arenbenla Longchar, Baskar Venkidasamy, Benod Kumar Kondapavuluri, Muthu Thiruvengadam, Mansour Ghorbanpour, Sathianarayanan Sankaran   +6 more
wiley   +1 more source

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source