Results 51 to 60 of about 6,615 (212)

Brain Involvement in Leishmaniasis

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Camila S. Freitas, Eduardo A. F. Coelho, Myron Christodoulides   +2 more
wiley   +1 more source

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis. [PDF]

, 2017
Leishmania parasites utilize adaptive evasion mechanisms in infected macrophages to overcome host defenses and proliferate. We report here that the PERK/eIF2α/ATF4 signaling branch of the integrated endoplasmic reticulum stress response (IERSR) is ...
Aktas, B.H., Calegari-Silva, T.C., Cavalcanti, Á., Dias-Teixeira, K.L., Fasel, N., Gomes, C.M., Lopes, U.G., Medina, J.M., Pereira, RMS, Real, F., Santana, AKM, Silva, J.S., Teteo, N., Vivarini, Á.C.   +13 more
core   +3 more sources

Comportamiento de flagelados de la familia Trypanosomatidae en dos medios de cultivo modificados

Biomédica: revista del Instituto Nacional de Salud, 1988
Se reporta un medio de cultivo monofásico sólido (NNN modificado) y un medio monofásico líquido (RE I modificado) de gran utilidad para cultivos in vitro de flagelados de la Familia Trypanosomatidae.
Sofía Duque Beltrán, Elvia Cáceres Vega, Augusto Corredor Arjona   +2 more
doaj   +1 more source

Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections. [PDF]

PLoS Neglected Tropical Diseases, 2017
In infected mammalian cells, Leishmania parasites reside within specialized compartments called parasitophorous vacuoles (LPVs). We have previously shown that Retro-2, a member of a novel class of small retrograde pathway inhibitors caused reduced LPV ...
Evan Craig, Charles-Eugene Huyghues-Despointes, Chun Yu, Emma L Handy, Jason K Sello, Peter E Kima   +5 more
doaj   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

Draft Genome Sequences of Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) mexicana, and Leishmania (Leishmania) aethiopica, Potential Etiological Agents of Diffuse Cutaneous Leishmaniasis.

Microbiology resource announcements, 2019
We present here the draft genome sequences of Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) mexicana, and Leishmania (Leishmania) aethiopica, potential etiological agents of diffuse cutaneous leishmaniasis (DCL). Sequence data were obtained using PacBio and MiSeq platforms.
Batra, Dhwani, Lin, Wuling, Narayanan, Vidhya, Rowe, Lori A., Sheth, Mili, Zheng, Yueli, Loparev, Vladimir, de Almeida, Marcos   +7 more
openaire   +2 more sources

In Situ Evaluation of Macrophage Populations and Inflammasome Components in Cutaneous and Mucocutaneous Leishmaniasis

Parasite Immunology, Volume 47, Issue 9, September 2025.
ABSTRACT American tegumentary leishmaniasis (ATL) affects the skin and mucous membranes, with a spectrum shaped by Th1/Th2 responses. This study investigated inflammasome activation in correlation with macrophage subpopulations, tissue parasitism, and histological changes in cutaneous and mucocutaneous leishmaniasis. We assessed inflammasome activation,
Caroline de Heleno Chagas de Carvalho, Gabriela Venicia Araujo Flores, Carmen Maria Sandoval Pacheco, Vania Lucia da Ribeiro da Matta, Carolina de Esteves de Morais, Ricardo Romiti, Walter Belda Júnior, Márcia Dalastra Laurenti   +7 more
wiley   +1 more source

Nueva estrategia terapéutica basada en nanotecnología contra leishmaniasis tegumentaria en Ecuador = New pharmacological strategy based in nanotechnology against cutaneous leishmaniasis in Ecuador [PDF]

, 2010
Leishmaniasis is an endemic disease with wide distribution in tropical and subtropical regions around the world. It is considered that the incidence of this infection would be increased due to the progressive urbanization process which consequence is the
Loayza Villa, María Fernanda
core  

Tegumentary leishmaniasis and coinfections other than HIV [PDF]

, 2018
BackgroundTegumentary leishmaniasis (TL) is a disease of skin and/or mucosal tissues caused by Leishmania parasites. TL patients may concurrently carry other pathogens, which may influence the clinical outcome of TL.Methodology and principal findingsThis
A Asilian, A Belehu, A Lenis, A Yoshida, A Zuckerman, AC La Flamme, AE Paniz-Mondolfi, AF Vega Benedetti, Alejandro Llanos-Cuentas, AM Da-Cruz, B Bastrenta, B Mougin, BC Walton, C Gimblet, C Khayeka-Wandabwa, C Kilkenny, C Parodi, CL Hoyos, CM Vendrame, D Moher, D Sacks, D Sacks, D Wu, Dalila Y. Martínez, DG Di Luca, DG Mendes, DJ Mock, DS Matos, DWT Cromptom, E Martínez, EE Zijlstra, EL Malchiodi, F Oliveira, F Pezeshkpoor, FM Frank, H Mortazavi, H Murray, HC Santiago, HJ McSorley, ICI Kahandawaarachchi, IM Goulart, J Alexander, J Alexander, J Alvar, J Arevalo, J Gil, J Kolbaum, J Torrealba, J van Griensven, JB Malone, JE Martinez, Jean-Claude Dujardin, JL Lemesre, JML Costa, K Al-Aboud, K Tarqui, Katja Polman, Kristien Verdonck, L Carvalho, M Akhoundi, M Rodríguez-Sosa, M-A Hartley, MA Escobar, Marleen Boelaert, MB de Lima Barros, MD Sadick, MF Garcia Bustos, MG Chiaramonte, MG Chiaramonte, MG Chiaramonte, MJ Yazdanpanah, MK Basu, NA Patrao, OA Adegboye, OJ Pung, OJ Pung, OS Andersen, P Delobel, P Diosque, P Kaye, P Layegh, P Mulvaney, P Scott, Paul M. Kaye, PL Yeyati, PM Coelho, PM Peçanha, R Reithinger, RA Pinna, RB Azeredo-Coutinho, RB Azeredo-Coutinho, RE Coleman, RE Coleman, RE Coleman, RE Coleman, RE Coleman, RM Abdel Wahab, RS Barnetson, S Naik, S Pelletreau, SE O'Neal, SH El-Safi, SP Agudelo, T Newlove, TJ Lamb, TM Chiller, TW Hand, V Carregaro, Vanessa Adaui, W Peters, Walderez O. Dutra, WC Gause, Y Alviarez, ZASF Liban Ee   +113 more
core   +3 more sources

Different Derivatives of Plumbagin Analogue: Bioavailability and Their Toxicity Studies

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Plumbagin, discovered in Plumbago zeylanica, has potential therapeutic effects such as anticancer, antimicrobial, and anti‐inflammatory characteristics. It has traditionally been used to treat anemia and rheumatic pain, but its therapeutic application is limited because of low bioavailability and toxicity risk factors.
Souparnika Thekkumkara, Arenbenla Longchar, Baskar Venkidasamy, Benod Kumar Kondapavuluri, Muthu Thiruvengadam, Mansour Ghorbanpour, Sathianarayanan Sankaran   +6 more
wiley   +1 more source