Results 231 to 240 of about 116,783 (314)

Rho Kinase Inhibitor Y-27632 Prolongs the Life Span of Adult Human Keratinocytes, Enhances Skin Equivalent Development, and Facilitates Lentiviral Transduction

, 2012
Ellen H. van den Bogaard, Diana Rodijk‐Olthuis, Patrick A.M. Jansen, Ivonne M.J.J. van Vlijmen‐Willems, P.E.J. van Erp, Irma Joosten, Patrick L.J.M. Zeeuwen, Joost Schalkwijk   +7 more
openalex   +2 more sources

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Human Platelet Lysate Media Supplement Supports Lentiviral Transduction and Expansion of Human T Lymphocytes While Maintaining Memory Phenotype. [PDF]

J Immunol Res, 2019
Canestrari E, Steidinger HR, McSwain B, Charlebois SJ, Dann CT.   +4 more
europepmc   +1 more source

Vector copy number analysis using droplet digital PCR method in hematopoietic stem cells and T lymphocytes after lentiviral transduction: optimization and limitations [PDF]

Aude Parcelier, Julien Buisset, Émilie Neveu, Bastien Kauffmann, Sandrine Fraboulet, Peggy Sanatine, Samia Martin, Cédrick Rousseaux, Nadia Avenier, Sabine Charrier   +9 more
openalex   +1 more source

276. Development and GMP Validation of Large Scale Lentiviral Transduction of CD34+ Cells for Metacromatic Leukodystrophy and Wiskott-Aldrich Syndrome Gene Therapy Clinical Trials [PDF]

, 2010

openalex   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells. [PDF]

J Vis Exp, 2018
Nanbakhsh A, Best B, Riese M, Rao S, Wang L, Medin J, Thakar MS, Malarkannan S.   +7 more
europepmc   +1 more source

Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage [PDF]

, 2014
Jonathan M. Brunger, Nguyen P.T. Huynh, Caitlin M. Guenther, Pablo Pérez‐Piñera, Franklin T. Moutos, Johannah Sanchez‐Adams, Charles A. Gersbach, Farshid Guilak   +7 more
openalex   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Optimization of lentiviral transduction parameters and its application for CRISPR-based secretome modification of human endometrial mesenchymal stem cells. [PDF]

Cell Cycle, 2019
Deryabin P, Griukova A, Shatrova A, Petukhov A, Nikolsky N, Borodkina A.   +5 more
europepmc   +1 more source