Results 91 to 100 of about 122,780 (298)
The aim of this work was to evaluate the efficiency and duration of gene expression mediated by a VSV-G pseudotyped last generation lentiviral (LV) vector.
Massimo Conese+3 more
doaj +1 more source
Lentivirus-induced interferon inhibits maturation and proliferation of monocytes and restricts the replication of caprine arthritis-encephalitis virus [PDF]
M. Christine Zink, Opendra Narayan
openalex +1 more source
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu+7 more
wiley +1 more source
Risk factors associated with small-ruminant lentiviruses in sheepfold buildings
Introduction Small-ruminant lentivirus (SRLV) infection is widespread across Europe. It causes substantial economic losses in sheep breeding. The main route of SRLV infection is through the mother’s milk, especially colostrum However, infection can also ...
Wiktor Bojar+6 more
doaj +1 more source
The catalytic properties of the reverse transcriptase of the lentivirus equine infectious anemia virus [PDF]
Tamar Rubinek+5 more
openalex +1 more source
AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu+8 more
wiley +1 more source
INSPIIRED: Quantification and Visualization Tools for Analyzing Integration Site Distributions
Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development.
Charles C. Berry+16 more
doaj +1 more source
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng+7 more
wiley +1 more source
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang+8 more
wiley +1 more source
The effect of Id1 gene silencing on the neural differentiation of MSCs
We aimed to construct a highly efficient, lentivirus-mediated vector for RNA interference (RNAi) silencing of the Id1 gene and to examine whether silencing of this gene promotes the neural differentiation of mesenchymal stem cells (MSCs).
Xiao-qing Song+7 more
doaj +1 more source