Results 101 to 110 of about 154,885 (187)

Reversal of Stress‐Induced PIEZO1 Elevation with Mechanically Adapted Epicardial Patch for Myocardial Infarction Treatment

Advanced Science, EarlyView.
This work identifies fine‐tuning the expression of PIEZO1 as a critical molecular mechanism underlying the treatment of myocardial infarction by mechanically adapted cardiac patches, which can support the clinical translation of cardiac patch devices.
Yuwen Lu, Sibo Jiang, Ting Shen, Yuan Zhang, Chengbin He, Yun Gao, Liyin Shen, Qiao Jin, Yuting Zhao, Ping Liang, Chaochen Wang, Hongjie Hu, Jin He, Kaicheng Deng, Shuo Wang, Yunhe Chen, Jun Ling, Yang Zhu, Lenan Zhuang   +18 more
wiley   +1 more source

Neuroprotective effect of riboflavin kinase on cerebral ischemia injury in rats. [PDF]

Mol Med
Zou Y, Ruan M, Feng X, Liu F, Liu W, Chen S, Chu Z.   +6 more
europepmc   +1 more source

EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

Advanced Science, EarlyView.
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi, Ping Yang, Huaijin Qiao, Jinchen He, Bin Song, Hao Bai, Fengdi Jiang, Yining Zhang, Qian Li, Tao Yan, Wenlin Tu, Daojiang Yu, Shuyu Zhang   +12 more
wiley   +1 more source

Tau aggregation induces cell death in iPSC-derived neurons. [PDF]

Aging Brain
Tanabe H, Maeda S, Sano E, Sakai N, Endoh-Yamagami S, Okano H.   +5 more
europepmc   +1 more source

Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer

Advanced Science, EarlyView.
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin, Yongbiao Huang, Bin Li, Yuan Wang, Yan Li, Zhirui Chen, Zhe Tang, Chaofan Liu, Lei Zhang, Xianglin Yuan, Jianbo Tian, Bo Liu   +11 more
wiley   +1 more source

Ribosomal protein L9 is a potential therapeutic target for B-ALL through the activation of the p53 signaling pathway. [PDF]

Front Immunol
Li X, Meng W, Wang X, Huang S, Wang J, Liang H, Si D.   +6 more
europepmc   +1 more source

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation

Advanced Science, EarlyView.
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang, Jiayue Liu, Min Zhang, Juan Yang, Peihan Lian, Xiu Cheng, Jianhua Qin   +6 more
wiley   +1 more source

Periostin-mediated activation of NF-κB signaling promotes tumor progression and chemoresistance in glioblastoma. [PDF]

Sci Rep
Shang Y, Liang Y, Zhang B, Wu W, Peng Y, Wang J, Zhang M, Niu C.   +7 more
europepmc   +1 more source

CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
CXCL6's function in cholangiocarcinoma is underexplored. Here it is discovered that CXCL6 is upregulated in cholangiocarcinoma tissues and promotes proliferation and metastasis of it. CXCL6 functions through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping tumor lipid metabolism.
Tian He, Zi‐Yi Wang, Bin Xu, Cheng‐Jie Zhong, Lu‐Na Wang, Huan‐Chen Shi, Zi‐Yue Yang, Shi‐Qi Zhou, Hui Li, Bo Hu, Xiao‐Dong Zhu, Ying‐Hao Shen, Jian Zhou, Jia Fan, Hui‐Chuan Sun, Cheng Huang   +15 more
wiley   +1 more source

Haemophilia and access to gene therapy. [PDF]

EBioMedicine
Mahlangu J.
europepmc   +1 more source