Results 21 to 30 of about 157,834 (170)
Viruses, 2021 Lentiviral vectors have played a critical role in the emergence of gene-modified cell therapies, specifically T cell therapies. Tisagenlecleucel (Kymriah), axicabtagene ciloleucel (Yescarta) and most recently brexucabtagene autoleucel (Tecartus) are ...
Roman P. Labbé +2 more
doaj +1 more source
Fibrin-mediated lentivirus gene transfer: Implications for lentivirus microarrays [PDF]
Journal of Controlled Release, 2010 We employed fibrin hydrogel as a bioactive matrix for lentivirus mediated gene transfer. Fibrin-mediated gene transfer was highly efficient and exhibited strong dependence on fibrinogen concentration. Efficient gene transfer was achieved with fibrinogen concentration between 3.75 and 7.5mg/ml.
Shruti D, Raut +3 more
openaire +2 more sources
CLEAR Strategy Inhibited HSV Proliferation Using Viral Vectors Delivered CRISPR-Cas9
Pathogens, 2023 Herpes simplex virus type 1 (HSV-1) is a leading cause of encephalitis and infectious blindness. The commonly used clinical therapeutic drugs are nucleoside analogues such as acyclovir.
Min Ying +9 more
doaj +1 more source
The Inside Out of Lentiviral Vectors
Viruses, 2011 Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene ...
Stéphanie Durand, Andrea Cimarelli
doaj +1 more source
Inositol Phosphates and Retroviral Assembly: A Cellular Perspective
Viruses, 2021 Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been ...
Clifton L. Ricaña, Robert A. Dick
doaj +1 more source
INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes
Molecular Therapy: Methods & Clinical Development, 2017 Integration of new DNA into cellular genomes mediates replication of retroviruses and transposons; integration reactions have also been adapted for use in human gene therapy.
Eric Sherman +17 more
doaj +1 more source
HIV Diagnosis and Treatment through Advanced Technologies
Frontiers in Public Health, 2017 Human immunodeficiency virus (HIV) is the chief contributor to global burden of disease. In 2010, HIV was the fifth leading cause of disability-adjusted life years in people of all ages and leading cause for people aged 30–44 years. It is classified as a
Hafiza Fizzah Zulfiqar +10 more
doaj +1 more source
eLife, 2019 Direct conversion of human somatic fibroblasts into induced neurons (iNs) allows for the generation of functional neurons while bypassing any stem cell intermediary stages.
Joseph Herdy +9 more
doaj +1 more source
Beyond retrovirus infection: HIV meets gene therapy
Genetics and Molecular Biology, 2006 The human immunodeficiency virus (HIV) is classified as a retrovirus because of its RNA genome and the fact that it requires reverse transcriptase to convert it into DNA.
Flávia Helena da Silva +2 more
doaj +1 more source
Retrogradely Transportable Lentivirus Tracers for Mapping Spinal Cord Locomotor Circuits
Frontiers in Neural Circuits, 2018 Retrograde tracing is a key facet of neuroanatomical studies involving long distance projection neurons. Previous groups have utilized a variety of tools ranging from classical chemical tracers to newer methods employing viruses for gene delivery.
Imran S. Sheikh +7 more
doaj +1 more source