Results 21 to 30 of about 173,548 (215)
Gene Therapy Applications of Non-Human Lentiviral Vectors
Viruses, 2020 Recent commercialization of lentiviral vector (LV)-based cell therapies and successful reports of clinical studies have demonstrated the untapped potential of LVs to treat diseases and benefit patients. LVs hold notable and inherent advantages over other
Altar M. Munis
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Viruses, 2023 Feline immunodeficiency virus (FIV) is a lentivirus in the family Retroviridae that infects domestic cats resulting in an immunodeficiency disease featuring a progressive and profound decline in multiple sets of peripheral lymphocytes. Despite compelling
Brian G. Murphy +6 more
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Viruses, 2021 Lentiviral vectors have played a critical role in the emergence of gene-modified cell therapies, specifically T cell therapies. Tisagenlecleucel (Kymriah), axicabtagene ciloleucel (Yescarta) and most recently brexucabtagene autoleucel (Tecartus) are ...
Roman P. Labbé +2 more
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In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction [PDF]
, 2010 We investigated whether human articular chondrocytes can be labeled efficiently and for long-term with a green fluorescent protein (GFP) lentivirus and whether the viral transduction would influence cell proliferation and tissue-forming capacity.
Candrian, Christian +9 more
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Restriction of lentivirus in monkeys [PDF]
Proceedings of the National Academy of Sciences, 2002 Retroviruses are able to cross species barriers and have done so many times throughout evolution. Perhaps as a consequence, dominant mechanisms have arisen to block infection by murine retroviruses in mice (restriction factor Fv1) and humans (restriction factor Ref1), as well as in other mammals.
Caroline, Besnier +2 more
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Fibrin-mediated lentivirus gene transfer: Implications for lentivirus microarrays [PDF]
Journal of Controlled Release, 2010 We employed fibrin hydrogel as a bioactive matrix for lentivirus mediated gene transfer. Fibrin-mediated gene transfer was highly efficient and exhibited strong dependence on fibrinogen concentration. Efficient gene transfer was achieved with fibrinogen concentration between 3.75 and 7.5mg/ml.
Shruti D, Raut +3 more
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CLEAR Strategy Inhibited HSV Proliferation Using Viral Vectors Delivered CRISPR-Cas9
Pathogens, 2023 Herpes simplex virus type 1 (HSV-1) is a leading cause of encephalitis and infectious blindness. The commonly used clinical therapeutic drugs are nucleoside analogues such as acyclovir.
Min Ying +9 more
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Lentivirus-mediated circMEF2A2 function investigation in vivo.
, 2023 (A, B) qRT-PCR analysis of circMEF2A2 in the cDNA samples generated from the breast muscles of LV-si-circMEF2A2, LV-si-NC, LV-ov-circMEF2A2, and LV-ov-NC infected chicks, n = 3.
Yuqi Chen (602230) +10 more
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The Inside Out of Lentiviral Vectors
Viruses, 2011 Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene ...
Stéphanie Durand, Andrea Cimarelli
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Inositol Phosphates and Retroviral Assembly: A Cellular Perspective
Viruses, 2021 Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been ...
Clifton L. Ricaña, Robert A. Dick
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