Results 41 to 50 of about 157,834 (170)
Turkish Journal of Hematology, 2023 Objective: Hemophilia A is an X-linked recessive bleeding disorder caused by a deficiency of plasma coagulation factor VIII (FVIII), and it accounts for about 80%-85% of all cases of hemophilia.
Cansu Hemşinlioğlu +14 more
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FIV: from lentivirus to lentivector [PDF]
The Journal of Gene Medicine, 2004 Molecular virological understanding of the feline immunodeficiency virus (FIV) life cycle is increasing, facilitating rational derivation of improved vectors from this non-primate lentivirus. The packaging signal has been mapped, a central DNA flap has been identified, and class I integrase mutants have been validated.
Dyana T, Saenz, Eric M, Poeschla
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Translational NeuroscienceSpinal cord injury (SCI) seriously affects the health of humans and quality of life, causing disabilities. Due to the ever-increasing traffic and cases of natural disasters, such as earthquakes, the incidence of SCI increases every year, thus causing a ...
Zheng Meng-ling +10 more
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mBio, 2020 Despite their exceptional potencies, the broad tropism of most commonly used lentivirus (LV) vectors limits their use for targeted gene delivery in vivo.
Christina L. Parker +4 more
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Foamy Virus Vectors for HIV Gene Therapy
Viruses, 2013 Highly active antiretroviral therapy (HAART) has vastly improved outcomes for patients infected with HIV, yet it is a lifelong regimen that is expensive and has significant side effects.
Grant D. Trobridge, Miles E. Olszko
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Lentivirus Production, Lentivirus Transduction, and Sorting Protocol v1
, 2023 Lentivirus Production, Lentivirus Transduction, and Sorting Protocol for making the transduced iPSCs and SH-SY5Ys
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Lentivirus-induced immune dysregulation [PDF]
Veterinary Immunology and Immunopathology, 2008 FIV/HIV infections are associated with an early robust humoral and cellular anti-viral immune response followed by a progressive immune suppression that eventually results in AIDS. Several mechanisms responsible for this immune dysfunction have been proposed including cytokine dysregulation, immunologic anergy and apoptosis, and inappropriate ...
Mary B, Tompkins, Wayne A, Tompkins
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Engineering a DYRK1B R102C mutation: insights into metabolic syndrome pathogenesis through lentiviral gene delivery [PDF]
Medical Laboratory JournalBackground: A rare heterozygous DYRK1B mutation (R102C) recently linked to a familial form of metabolic syndrome prompted this study to introduce the R102C mutation into the mouse DYRK1B gene, utilizing recombinant lentiviruses for long-term gene ...
Afrooz Daneshparvar +6 more
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Molecular Therapy, 2007 In 2003, the field of gene therapy faced serious adverse events, apparently arising in part from insertional activation of the LMO2 gene in a clinical gene therapy trial in Paris that sought to correct deficiency of the interleukin-2 common -chain receptor (IL2RG).
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A transitional endogenous lentivirus from the genome of a basal primate and implications for lentivirus evolution [PDF]
Proceedings of the National Academy of Sciences, 2008 Lentiviruses chronically infect a broad range of mammalian species and have been transmitted from primates to humans, giving rise to multiple outbreaks of HIV infection over the past century. Although the circumstances surrounding these recent zoonoses are becoming clearer, the nature and timescale of interaction between ...
Gifford, R +5 more
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