Results 61 to 70 of about 166,720 (266)
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
Lentivirus-transduced human iPSCs differentiate to multipotent neural precursor cells.
, 2016 (A) Representative micrographs of human iPSCs transduced with a lentiviral vector containing the Photinus pyralis luciferase gene and puromycin resistance cassette.
Craig M. Walsh (2839346) +7 more
core +1 more source
Sources of Error in Mammalian Genetic Screens
G3: Genes, Genomes, Genetics, 2016 Genetic screens are invaluable tools for dissection of biological phenomena. Optimization of such screens to enhance discovery of candidate genes and minimize false positives is thus a critical aim.
Laura Magill Sack +4 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui +14 more
wiley +1 more source
Lentivirus-mediated Atg3 overexpression in SKM-1 cells.
, 2016 (A) At 72 h post-transfection, SKM-1 cells transfected with FLAG-tagged ATG3-overexpressing vector and empty vector were detected by fluorescence and light microscopy. Western blotting of Atg3 protein (40 kD band) in SKM-1 cells detected by Atg3 (B and C)
Lin Zhuang (389736) +6 more
core +1 more source
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Common Modular Structure of Lentivirus LTRs
, 1996 Retroviruses are expressed under the control of viral control regions designated long terminal repeats (LTRs), which contain all signals for transcriptional initiation as well as transcriptional termination.
Frech, Kornelie +2 more
core +1 more source
Advanced Science, EarlyView.TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang +12 more
wiley +1 more source
Impact of Veterinary Vaccines on Human Health and Probable Challenges
Acta Veterinaria Eurasia, 2021 Md. Mehadi Hasan SOHAG +1 more
doaj +1 more source
Specific Inhibition of SRC Kinase Impairs Malignant Glioma Growth In Vitro and In Vivo
Molecular Therapy: Nucleic Acids, 2012 Malignant glioma is a severe cancer with a poor prognosis. Local occurrence and rare metastases of malignant glioma make it a suitable target for gene therapy. Several studies have demonstrated the importance of Src kinase in different cancers.
Hanna Stedt +7 more
doaj +1 more source