Results 61 to 70 of about 98,106 (307)

HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium [PDF]

, 2013
Background: While acute lung injury (ALI) contributes significantly to critical illness, it resolves spontaneously in many instances. The majority of patients experiencing ALI require mechanical ventilation.
Bonney, Megan, Borchers, Christoph H., Brodsky, Kelley, Eckle, Tobias, Eltzschig, Holger K., Han, Jun, Kominsky, Douglas J., Mariani, Thomas J., Mittelbronn, Michel Guy André, Packard, Thomas   +9 more
core   +3 more sources

Peripheral neuropathy in lentivirus infection

AIDS, 2004
As distal sensory polyneuropathy (DSP) is a major neurological complication of HIV-1 infection, we investigated the extent of peripheral nervous system disease in animals infected with the lentivirus, feline immunodeficiency virus (FIV), because it causes neurological disease and immunosuppression in cats similar to HIV-1 in humans.After infection with
Kennedy, James M., Hoke, Ahmet, Zhu, Yu, Johnston, James B., van Marle, Guido, Silva, Claudia, Zochodne, Douglas W., Power, Christopher   +7 more
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Identification of New Single Nucleotide Polymorphisms Potentially Related to Small Ruminant Lentivirus Infection Susceptibility in Goats Based on Data Selected from High-Throughput Sequencing

Pathogens
Small ruminant lentivirus (SRLV) infections are spread in the flocks of sheep and goats all over the world, causing economic loss. Although only a fraction of infected animals develop disease symptoms, all of them may shed the virus, causing uncontrolled
Magdalena Materniak-Kornas, Katarzyna Ropka-Molik, Katarzyna Piórkowska, Joanna Kowalik, Tomasz Szmatoła, Jacek Sikora, Aldona Kawęcka, Jacek Kuźmak   +7 more
doaj   +1 more source

A Seroprevalence Survey of Maedi-Visna Among Twenty-Four Ovine Floks from Twelve Regions of China

Journal of Integrative Agriculture, 2013
Maedi-visna virus (MVV) is an ovine lentivirus that is widespread in many countries worldwide. Both clinical and subclinical MVV infections cause substantial economic losses.
Ke-shan ZHANG, Ji-jun HE, Yong-jie LIU, You-jun SHANG, Xiang-tao LIU   +4 more
doaj   +1 more source

Utility of Roche Elecsys anti-SARS-CoV-2 S in ascertaining post-vaccine neutralizing antibodies

Journal of Clinical Virology Plus, 2023
With widespread global COVID-19 vaccine coverage, a scalable, cost-effective, and standardized tool to ascertain post-vaccine immunity is a dire need. Neither clinical evaluations of vaccine efficacy, nor live virus antibody neutralization assays fulfill
Javeria Aijaz, Fatima Kanani, Fouzia Naseer   +2 more
doaj   +1 more source

Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer. [PDF]

, 2013
Aged (>50 years old) human immunodeficiency virus (HIV) patients are the fastest-growing segment of the HIV-infected population in the USA and despite antiretroviral therapy, HIV-associated neurocognitive disorder (HAND) prevalence has increased or ...
Adame, Anthony, Dumaop, Wilmar, Ellis, Ron, Fields, Jerel, Grant, Igor, Letendre, Scott, Mante, Michael, Masliah, Eliezer, Patrick, Christina, Rockenstein, Edward, Spencer, Brian   +10 more
core   +2 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Lessons in AIDS Vaccine Development Learned from Studies of Equine Infectious, Anemia Virus Infection and Immunity

Viruses, 2013
Equine infectious anemia (EIA), identified in 1843 [1] as an infectious disease of horses and as a viral infection in 1904, remains a concern in veterinary medicine today.
Jodi K. Craigo, Ronald C. Montelaro
doaj   +1 more source

Studies on processing, particle formation, and immunogenicity of the HIV-1 gag gene product: a possible component of a HIV vaccine [PDF]

, 1992
Antigens in a particulate conformation were shown to be highly immunogenic in mammals. For this reason, the particle forming capacity of derivatives of the HIV-1 group specific core antigen p55 gag was assayed and compared dependent on various expression
Deby, G., Fliessbach, H., Motz, M., Niedrig, M., von Brunn, A., Wagner, R., Wanner, G., Wolf, Hans J.   +7 more
core   +1 more source