Results 1 to 10 of about 134,905 (296)
BMC Genomics, 2021 Background Brown adipose tissue (BAT) is specialized to dissipate energy in the form of heat. BAT-mediated heat production in rodents and humans is critical for effective temperature adaptation of newborns to the extrauterine environment immediately ...
Sujoy Ghosh +10 more
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Leptin-Activity Modulators and Their Potential Pharmaceutical Applications
Biomolecules, 2021 Leptin, a multifunctional hormone primarily, but not exclusively, secreted in adipose tissue, is implicated in a wide range of biological functions that control different processes, such as the regulation of body weight and energy expenditure ...
Marianna Greco +6 more
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A small genomic region containing several loci required for gastrulation in Drosophila. [PDF]
PLoS ONE, 2009 Genetic screens in Drosophila designed to search for loci involved in gastrulation have identified four regions of the genome that are required zygotically for the formation of the ventral furrow.
Sam J Mathew +2 more
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Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells. [PDF]
PLoS ONE, 2014 A key element in the regulation of subcellular branching and tube morphogenesis of the Drosophila tracheal system is the organization of the actin cytoskeleton by the ERM protein Moesin.
Fiona Paul Ukken +3 more
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Biomolecules, 2023 Craniopharyngioma (CP) is a benign tumor with a high rate of obesity and frequent recurrence. Moreover, the role of leptin/leptin receptors axis in obesity and the prognosis of CP is still unknown.
Youchao Xiao +9 more
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Concordance of bioactive vs. total immunoreactive serum leptin levels in children with severe early onset obesity. [PDF]
PLoS ONE, 2017 Leptin secreted from adipose tissue signals peripheral energy status to the brain. Monogenic leptin deficiency results in severe early onset obesity with hyperphagia.
Juraj Stanik +8 more
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Normal leptin expression, lower adipogenic ability, decreased leptin receptor and hyposensitivity to Leptin in Adolescent Idiopathic Scoliosis. [PDF]
PLoS ONE, 2012 Leptin has been suggested to play a role in the etiology of Adolescent Idiopathic Scoliosis (AIS), however, the leptin levels in AIS girls are still a discrepancy, and no in vitro study of leptin in AIS is reported.
Guoyan Liang +8 more
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Glucose enhances leptin signaling through modulation of AMPK activity. [PDF]
PLoS ONE, 2012 Leptin exerts its action by binding to and activating the long form of leptin receptors (LEPRb). LEPRb activates JAK2 that subsequently phosphorylates and activates STAT3.
Haoran Su +3 more
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Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons
Molecular Metabolism, 2015 Objective: Leptin modulates food reward via central leptin receptor (LepRb) expressing neurons. Food reward requires stimulation of midbrain dopamine neurons and is modulated by central leptin action, but the exact central mechanisms remain unclear ...
Amanda Laque +10 more
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Molecular Metabolism, 2014 Objective: Leptin responsive neurons play an important role in energy homeostasis, controlling specific autonomic, behavioral, and neuroendocrine functions.
Kavon Rezai-Zadeh +8 more
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