Results 1 to 10 of about 273,643 (354)
Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons
Molecular Metabolism, 2015 Objective: Leptin modulates food reward via central leptin receptor (LepRb) expressing neurons. Food reward requires stimulation of midbrain dopamine neurons and is modulated by central leptin action, but the exact central mechanisms remain unclear ...
Amanda Laque +10 more
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Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma [PDF]
, 2015 The prevalence of global obesity is increasing. Obesity is associated with general cancer-related morbidity and mortality and is a known risk factor for development of specific cancers.
Alfraidi, Albandri +5 more
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Leptin signaling and leptin resistance
Medical Review, 2022 Abstract With the prevalence of obesity and associated comorbidities, studies aimed at revealing mechanisms that regulate energy homeostasis have gained increasing interest. In 1994, the cloning of leptin was a milestone in metabolic research. As an adipocytokine, leptin governs food intake and energy homeostasis through leptin receptors
Jiarui Liu +3 more
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Nutrients, 2020 Leptin is a hormone released by adipose tissue that plays a key role in the control of energy homeostasis through its binding to leptin receptors (LepR), mainly expressed in the hypothalamus. Most scientific evidence points to leptin’s satiating effect being due to its dual capacity to promote the expression of anorexigenic neuropeptides and to reduce ...
Patricia Seoane-Collazo +3 more
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BMC Genomics, 2021 Background Brown adipose tissue (BAT) is specialized to dissipate energy in the form of heat. BAT-mediated heat production in rodents and humans is critical for effective temperature adaptation of newborns to the extrauterine environment immediately ...
Sujoy Ghosh +10 more
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Leptin-Activity Modulators and Their Potential Pharmaceutical Applications
Biomolecules, 2021 Leptin, a multifunctional hormone primarily, but not exclusively, secreted in adipose tissue, is implicated in a wide range of biological functions that control different processes, such as the regulation of body weight and energy expenditure ...
Marianna Greco +6 more
doaj +1 more source
Annual Review of Physiology, 2000 ▪ Abstract The discovery of the adipose-derived hormone leptin has generated enormous interest in the interaction between peripheral signals and brain targets involved in the regulation of feeding and energy balance. Plasma leptin levels correlate with fat stores and respond to changes in energy balance. It was initially proposed that leptin serves a
R S, Ahima, J S, Flier
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Aquaculture Reports, 2022 In mammals, leptin is an endocrine hormone involved in the regulation of feeding and energy metabolism, and glucocorticoids were previously reported to induce leptin gene expression.
Aifen Yan +7 more
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A small genomic region containing several loci required for gastrulation in Drosophila. [PDF]
PLoS ONE, 2009 Genetic screens in Drosophila designed to search for loci involved in gastrulation have identified four regions of the genome that are required zygotically for the formation of the ventral furrow.
Sam J Mathew +2 more
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Leptin signaling and leptin resistance [PDF]
Frontiers of Medicine, 2013 Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body weight. Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesity. Leptin controls energy balance and body weight mainly through leptin receptor b (LEPRb)-expressing neurons in the brain ...
Yingjiang, Zhou, Liangyou, Rui
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