Results 131 to 140 of about 273,643 (354)

New pharmacological perspectives for the leptin receptor in the treatment of obesity

Frontiers in Endocrinology, 2014
After its discovery in 1994, leptin became the great hope as an anti-obesity treatment based on its ability to reduce food intake and increase energy expenditure.
Clara eRoujeau, Ralf eJockers, Julie eDam   +2 more
doaj   +1 more source

The relationship of leptin and thyroid hormones with milk yield and some fertility parameters in Simmental dairy cows during transition period

, 2021
Özkan Duru, Alparslan Kadir Devrim, Hasan Ceyhun Macun, Sibel Yasa Duru, Ali Şenol   +4 more
openalex   +1 more source

Peripheral nerve demyelination and a leptin receptor mutation: The obese Zucker rat sciatic nerve demyelination occurs with a centripetal pattern defect [PDF]

, 2020
Jacques Gilloteaux, Kritika Subramanian, Nadia Solomon, Charles Nicaise   +3 more
openalex   +1 more source

[Leptin, leptin gene, leptin gene receptor polymorphisms and pregnancy].

Ginekologia polska, 2008
The article presents information about leptin as the major metabolic hormone. The structure, localization of the hormone and its receptor have been described focusing on maturation and fertility processes. Several polymorphisms of leptin gene and its receptor have been described as potential developmental factors of pregnancy complications such as ...
Rafał, Iciek, Ewa, Wender-Ozegowska, Agnieszka, Seremak-Mrozikiewicz, Krzysztof, Drews, Jacek, Brazert   +4 more
openaire   +1 more source

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.
Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner, Antje Augstein, Mahmoud Abdellatif, André Lourenço, Adelino Leite‐Moreira, Inês Falcão‐Pires, Sarah Werner, Holger Thiele, Simon Sedej, Antje Schauer, Volker Adams   +10 more
wiley   +1 more source

Long-duration leptin transgene expression in dorsal vagal complex does not alter bone parameters in female Sprague Dawley rats

Bone Reports
The hypothalamus and dorsal vagal complex (DVC) are both important for integration of signals that regulate energy balance. Increased leptin transgene expression in either the hypothalamus or DVC of female rats was shown to decrease white adipose tissue ...
Russell T. Turner, Adam J. Branscum, Urszula T. Iwaniec   +2 more
doaj   +1 more source

Activation of the Sympathetic Nervous System by Galanin-Like Peptide—A Possible Link between Leptin and Metabolism [PDF]

, 2003
Karl R. Hansen, Stephanie M. Krasnow, Michael A. Nolan, Gregory S. Fraley, James W. Baumgartner, Donald K. Clifton, Robert A. Steiner   +6 more
openalex   +1 more source

Adult Male Syrian Hamsters (Mesocricetus auratus) Exhibit Daily Oscillations in Their Serum Levels of Melatonin and Leptin As Well As in the Expression of the GnRH, GnIH, and Kisspeptin Genes

, 2023
Emine İnci Balkan, Bülent Gündüz
openalex   +2 more sources

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Leukemia Inhibitory Factor Represses GnRH Gene Expression via cFOS during Inflammation in Male Mice. [PDF]

, 2019
BackgroundThe mechanisms whereby neuroinflammation negatively affects neuronal function in the hypothalamus are not clear. Our previous study determined that obesity-mediated chronic inflammation elicits sex-specific impairment in reproductive function ...
Coss, Djurdjica, Lainez, Nancy M
core   +1 more source