Results 121 to 130 of about 2,380,940 (353)

Advances of the Relationship between Leptin System and Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2014
Leptin system plays an important role in lung inflammation and tumorigenesis, but the precise function in the tumormicrovironment and the prognosis value of the leptin system in lung cancer have not been fully elucidated.
Tengfei WEI, Longkun LU, Qian SHEN, Chaoping FANG   +3 more
doaj   +1 more source

Neurochemical Characterization of Body Weight-Regulating Leptin Receptor Neurons in the Nucleus of the Solitary Tract

Endocrinology, 2012
The action of peripherally released leptin at long-form leptin receptors (LepRb) within the brain represents a fundamental axis in the regulation of energy homeostasis and body weight.
Alastair S. Garfield, C. Patterson, S. Skora, F. Gribble, F. Reimann, M. Evans, M. Myers, L. Heisler   +7 more
semanticscholar   +1 more source

GDF15 Is Elevated in Eating Disorders and Is Involved in the Gut‐Brain Axis via Ghrelin

European Eating Disorders Review, EarlyView.
ABSTRACT Objective GDF15 induces anorexia and visceral discomfort, regulating appetite, food intake and potentially metabolic responses. However, its role in eating disorders remains unexplored. Method A total of 145 participants were recruited (60 patients with anorexia nervosa, 20 with bulimia nervosa, 13 with binge eating disorder, 52 participants ...
Livio Tarchi, Giulia Brancolini, Sara Giachetti, Gaia Maiolini, Emanuele Cassioli, Eleonora Rossi, Gianluca Villa, Rachele Garella, Roberta Squecco, Paolo Rovero, Paolo Comeglio, Valdo Ricca, Francesco De Logu, Romina Nassini, Giovanni Castellini   +14 more
wiley   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Gene Expression of Leptin and Long Leptin Receptor Isoform in Endometriosis: A Case-Control Study

Obstetrics and Gynecology International, 2013
In this study, leptin/BMI ratio in serum and peritoneal fluid and gene expression of leptin and long form leptin receptor (OB-RL) were assessed in eutopic and ectopic endometria of women with endometriosis and controls.
Andrea Prestes Nácul, Sheila Bunecker Lecke, Maria Isabel Edelweiss, Débora Martinho Morsch, Poli Mara Spritzer   +4 more
doaj   +1 more source

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor*

Journal of Biological Chemistry, 1997
Leptin receptors include a long form (OBRl) with 302 cytoplasmic residues that is presumed to mediate most or all of leptins signaling, and several short forms, including one (OBRs) that has 34 cytoplasmic residues, is widely expressed, and is presumed ...
Christian Bjørbæk, S. Uotani, B. D. da Silva, J. Flier   +3 more
semanticscholar   +1 more source

Oat Bran Supplementation Improves Glucose Metabolism, Food Addiction, and Gut Microbiota in Rats With High‐Fat Diet‐Induced Obesity

Food Frontiers, EarlyView.
ABSTRACT Oat bran (OB), a byproduct of the oat milling process, is a nutrient‐dense cereal cultivated in cool, dry mountainous regions and is known for its potential health benefits. To explore its obesity‐alleviating effects and the underlying mechanisms, we examined the influence of OB on glucose metabolism, appetite‐regulating hormones, gut ...
Xue Bai, Meili Zhang, Yakun Zhang, Yuanyuan Zhang, Rui Huo, Qixin Gu, Ying Miao   +6 more
wiley   +1 more source

Celastrol inhibits the proliferation and migration of MCF-7 cells through the leptin-triggered PI3K/AKT pathway

Computational and Structural Biotechnology Journal, 2022
Leptin is the pivotal modulator in the onset and progression of breast cancer and obesity. Celastrol, which is extracted from the roots of Tripterygium wilfordi plants, exerts various anticancer bioactivities and has recently emerged as a candidate to ...
Pingping Chen, Bin Wang, Meng Li, Chunxue Cui, Fei Liu, Yonggang Gao   +5 more
doaj  

Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G > A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia

Journal of Experimental & Clinical Cancer Research, 2011
Background Approximately 20% of children and adolescents in Europe are overweight. Survivors of pediatric acute lymphoblastic leukemia (ALL) are at increased risk of overweight and obesity.
Gozdzik Jolanta, Sztefko Krystyna, Pietrzyk Jacek J, Balwierz Walentyna, Surmiak Marcin, Bik-Multanowski Miroslaw, Tomasik Przemyslaw J, Skoczen Szymon, Galicka-Latała Danuta, Strojny Wojciech   +9 more
doaj   +1 more source

Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta [PDF]

, 1997
Nigel Hoggard, Leif Hunter, J.S. Duncan, Lynda M. Williams, Paul Trayhurn, Julian G. Mercer   +5 more
openalex   +1 more source