Results 11 to 20 of about 2,380,940 (353)
Leptin-Activity Modulators and Their Potential Pharmaceutical Applications
Biomolecules, 2021 Leptin, a multifunctional hormone primarily, but not exclusively, secreted in adipose tissue, is implicated in a wide range of biological functions that control different processes, such as the regulation of body weight and energy expenditure ...
Marianna Greco +6 more
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Leptin and leptin receptor expressions in prostate tumors may predict disease aggressiveness? [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE: The aim of this study was to evaluate the expression of leptin and its receptor in histological sections of prostate tumors, and their association with prognostic factors.
Clarice F. Osório +4 more
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Folia Histochemica et Cytobiologica, 2008 Leptin and its receptor may be engaged in pathogenesis of breast cancer among various human tumors. In vitro investigations showed leptin-mediated escalation of estrogen synthesis and boosted activity of estrogen receptor ERalpha.
Mariola Sulkowska +4 more
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Leptin and leptin receptor expression in asthma [PDF]
Journal of Allergy and Clinical Immunology, 2009 The adipokine leptin is a potential new mediator for bronchial epithelial homeostasis. Asthma is a chronic inflammatory disease characterized by airway remodeling that might affect disease chronicity and severity. TGF-beta is a tissue growth factor the dysregulation of which is associated with airway remodeling.We sought to determine whether a ...
Andreina Bruno +9 more
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Definitions, 2020 Leptin receptor deficiency is a condition that causes severe obesity beginning in the first few months of life. Affected individuals are of normal weight at birth, but they are constantly hungry and quickly gain weight.
semanticscholar +1 more source
Leptin inhibits neutrophil apoptosis in children via ERK/NF-κB-dependent pathways. [PDF]
PLoS ONE, 2013 Previous studies have shown that delayed neutrophil apoptosis is associated with chronic airway diseases. Leptin is an adipocyte-derived hormone that acts as a regulator of energy homeostasis and food intake.
Zhizhi Sun +3 more
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Normal leptin expression, lower adipogenic ability, decreased leptin receptor and hyposensitivity to Leptin in Adolescent Idiopathic Scoliosis. [PDF]
PLoS ONE, 2012 Leptin has been suggested to play a role in the etiology of Adolescent Idiopathic Scoliosis (AIS), however, the leptin levels in AIS girls are still a discrepancy, and no in vitro study of leptin in AIS is reported.
Guoyan Liang +8 more
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Implication of Leptin-Signaling Proteins and Epstein-Barr Virus in Gastric Carcinomas. [PDF]
PLoS ONE, 2015 We investigated the clinicopathological implications of leptin-signaling proteins and Epstein-Barr virus (EBV)-infection status in gastric carcinomas. Immunohistochemistry for leptin signalling-related proteins (leptin, leptin-receptor, pSTAT3, ERK, pAkt,
Euno Choi +7 more
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Mutations in the Human Leptin and Leptin Receptor Genes as Models of Serum Leptin Receptor Regulation [PDF]
Diabetes, 2002 A part of serum Ob leptin, an adipocyte-secreted peptide, is bound to a soluble Ob receptor (sObR). Immunoreactive sObR was measured in 125 lean or obese control subjects (group 1), 18 individuals with a mutation in the leptin gene impairing leptin secretion (group 2), and 10 individuals with a mutation in the ObR gene, leading to production of a ...
Najiba Lahlou +6 more
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Leptin and Leptin Receptor Expression in the Rat Ovary [PDF]
Endocrinology, 2003 Leptin is an important satiety hormone and reproductive regulator and is found, along with its receptors, throughout the ovary. To date, the changes in ovarian expression of both of these proteins throughout the estrous cycle has not been studied, and the examination of protein expression has not distinguished between different forms of the receptor ...
Ryan, N. +3 more
openaire +4 more sources