Results 71 to 80 of about 76,631 (314)
Leptin Receptors Are Not Required for Roux-en-Y Gastric Bypass Surgery to Normalize Energy and Glucose Homeostasis in Rats [PDF]
, 2021 Mohammed K. Hankir +8 more
openalex +1 more source
Kinetics of Leptin Binding to the Q223R Leptin Receptor
PLoS ONE, 2014 Studies in human populations and mouse models of disease have linked the common leptin receptor Q223R mutation to obesity, multiple forms of cancer, adverse drug reactions, and susceptibility to enteric and respiratory infections. Contradictory results cast doubt on the phenotypic consequences of this variant.
Verkerke, Hans +5 more
openaire +4 more sources
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Aim To investigate the factors associated with BWL after gastrectomy using data from the phase III trial (JCOG1001). Methods This post hoc analysis included 728 patients from the JCOG1001. The percentage of BWL (%BWL) was defined as the proportion of decrease in body weight immediately before adjuvant chemotherapy initiation compared with that
Takanobu Yamada +16 more
wiley +1 more source
FRI031 A Novel Strategy To Detect Leptin Receptor (Lepr, fa) Mutation In Obesity And Diabetic Animal Model (Zucker Rats) [PDF]
, 2023 Xinyun Xu +7 more
openalex +1 more source
Transcriptional Characterization of Porcine Leptin and Leptin Receptor Genes
PLoS ONE, 2013 The leptin (LEP) and its receptor (LEPR) regulate food intake and energy balance through hypothalamic signaling. However, the LEP-LEPR axis seems to be more complex and its expression regulation has not been well described. In pigs, LEP and LEPR genes have been widely studied due to their relevance. Previous studies reported significant effects of SNPs
Pérez-Montarelo, Dafne +8 more
openaire +6 more sources
ZSF1 lean rats – How healthy are they?
Animal Models and Experimental Medicine, EarlyView.This study aimed to examine the health status, specifically the physiology and myocardial, vascular, and skeletal muscle function of lean ZSF1 rats by comparing them to age‐ and sex‐matched Wistar rats. Compared to Wistar controls, ZSF1 lean rats exhibited lower body weight, but showed increased heart, and skeletal muscle mass.
Antje Schauer +4 more
wiley +1 more source
Molecules, 2017 The aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of ...
Paweł Olczyk +9 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee +5 more
wiley +1 more source
Hypoxic Living and Exercise Training Alter Adipose Tissue Leptin/Leptin Receptor in Rats
Frontiers in Physiology, 2016 Background: Hypobaric hypoxia results in weight loss in obese individuals, and exercise training is advocated for the treatment of obesity and its related metabolic dysfunctions.
Yingli Lu +6 more
doaj +1 more source
Biological Reviews, EarlyView.ABSTRACT Human life history is derived compared to that of our closest living relatives, the great apes. It has been suggested that these derived traits are causally related to aspects of our ecology, social behaviour and cognitive abilities. However, resolving this requires that we know the evolutionary trajectory of our distinctive pattern of growth,
Paola Cerrito +2 more
wiley +1 more source