Results 71 to 80 of about 2,380,940 (353)

Leptin as a Key between Obesity and Cardiovascular Disease

Journal of Obesity & Metabolic Syndrome, 2020
Obesity increases the risk of cardiovascular disease through various influencing factors. Leptin, which is predominantly secreted by adipose tissue, regulates satiety homeostasis and energy balance, and influences cardiovascular functions directly and ...
Ki-Woon Kang, Minho Ok, Seong-Kyu Lee
doaj   +1 more source

Transcriptional Characterization of Porcine Leptin and Leptin Receptor Genes

PLoS ONE, 2013
The leptin (LEP) and its receptor (LEPR) regulate food intake and energy balance through hypothalamic signaling. However, the LEP-LEPR axis seems to be more complex and its expression regulation has not been well described. In pigs, LEP and LEPR genes have been widely studied due to their relevance. Previous studies reported significant effects of SNPs
Pérez-Montarelo, Dafne, Fernández, Almudena, Barragán, Carmen, Noguera, José Luis, Folch, Josep M., Rodríguez, M. Carmen, Óvilo, Cristina, Silió, Luis, Fernández, Ana I.   +8 more
openaire   +7 more sources

Leptin and leptin receptor polymorphisms and recurrent pregnancy loss [PDF]

Journal of Perinatology, 2013
Leptin signaling is important in the establishment of pregnancy. We sought to determine if single nucleotide polymorphisms (SNPs) in the leptin and leptin receptor genes are associated with idiopathic recurrent pregnancy loss (RPL).We conducted a case-control study with cases defined as women with idiopathic RPL and controls as parous women without ...
Alexandra G. Eller, Alexandra G. Eller, Robert M. Silver, Robert M. Silver, Lesa T. Nelson, Cara Heuser, Cara Heuser, Jeanette R. Chin, D W Branch, D W Branch   +9 more
openaire   +2 more sources

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Immunoreactivities of PPARγ2, leptin and leptin receptor in oviduct of Chinese brown frog during breeding period and pre-hibernation

European Journal of Histochemistry, 2014
The Chinese brown frog (Rana dybowskii) is a special amphibian with one unique physiological phenomenon, which is that its oviduct expands prior to hibernation, instead of during the breeding period.
Y. Liu, J. Weng, S. Huang, Y. Shen, X. Sheng, Y. Han, M. Xu, Q. Weng   +7 more
doaj   +1 more source

A potential adverse role for leptin and cardiac leptin receptor in the right ventricle in pulmonary arterial hypertension: effect of metformin is BMPR2 mutation-specific

Frontiers in Medicine, 2023
IntroductionPulmonary arterial hypertension is a fatal cardiopulmonary disease. Leptin, a neuroendocrine hormone released by adipose tissue, has a complex relationship with cardiovascular diseases, including PAH.
Megha Talati, Evan Brittain, Vineet Agrawal, Niki Fortune, Katie Simon, Sheila Shay, Xiaofang Zeng, Michael L. Freeman, James West, Anna Hemnes   +9 more
doaj   +1 more source

Inhibition of leptin and leptin receptor gene expression by silibinin-curcumin combination.

Asian Pacific Journal of Cancer Prevention, 2013
Leptin and its receptor are involved in breast carcinogenesis as mitogenic factors. Therefore, they could be considered as targets for breast cancer therapy. Expression of the leptin receptor gene could be modulated by leptin secretion.
Kazem Nejati-Koshki, A. Akbarzadeh, Mohammad Pourhasan-Moghaddam, A. Abhari, H. Dariushnejad   +4 more
semanticscholar   +1 more source

Leptin and leptin receptors during malaria infection in mice [PDF]

Folia Parasitologica, 2002
Leptin, which is involved in a range of physiological processes, could be an important factor in the pathogenesis of malaria. We found that levels of leptin in serum and urine in Plasmodium berghei-infected mice increased progressively after infection, reaching a maximum value on day 6 post-infection. Serum values were approximately five-fold higher in
Juan B. De Sanctis, Magdalena Pulido-Mendez, Alexis Rodríguez-Acosta   +2 more
openaire   +3 more sources

Emerging Nanotechnology Strategies for Obesity Therapy

Advanced Science, EarlyView.
Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang, Zhaoxu Meng, Yuezhu Zhao, Yake Qi, Zhou Li, He Lian   +5 more
wiley   +1 more source