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Drug targeting of leptin resistance
Life Sciences, 2015Leptin regulates glucose, lipid and energy homeostasis as well as feeding behavior, serving as a bridge between peripheral metabolically active tissues and the central nervous system (CNS). Indeed, this adipocyte-derived hormone, whose circulating levels mirror fat mass, not only exerts its anti-obesity effects mainly modulating the activity of ...
SANTORO, ANNA +2 more
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Leptin in normal physiology and leptin resistance
Science Bulletin, 2016Since the discovery of leptin as an adipokine in 1994, much progress has been made in the research about leptin. Circulating leptin binds to leptin receptor, activates STAT3-dependent and STAT3-independent signaling pathways, and plays an effective role in energy homeostasis, neuroendocrine function and metabolism mainly through acting on the central ...
Shufen Li, Xi Li
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Leptin-Signaling Pathways and Leptin Resistance
2009Leptin acts as an anorexigenic hormone in the brain, where the long form of the leptin receptor (LRb) is widely expressed in hypothalamic and extra-hypothalamic sites that are known to participate in diverse feeding circuits. The important role of leptin in energy homeostasis is demonstrated by the profound hyperphagia and morbid obesity in humans and ...
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[Leptin Signalings and Leptin Resistance].
Sheng li ke xue jin zhan [Progress in physiology], 2016Leptin plays a critical role in the regulation of energy balance and metabolic homeostasis. Impairment of leptin function is closely involved in the pathogenesis of obesity, diabetes mellitus and some other metabolic diseases. Leptin initiates intracellular signal transductions in the leptin-receptor-expressing neurons in the central nervous system to ...
Xiao-Ning, Yang +4 more
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2003
leptin was cloned in 1994 and shown to be secreted from adipocytes ([5][1]). This and subsequent studies demonstrated that leptin is made and secreted in proportion to the fat content of individual adipocytes ([4][2]).
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leptin was cloned in 1994 and shown to be secreted from adipocytes ([5][1]). This and subsequent studies demonstrated that leptin is made and secreted in proportion to the fat content of individual adipocytes ([4][2]).
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High‐Fat Diet Induces Leptin Resistance in Leptin‐Deficient Mice
Journal of Neuroendocrinology, 2014The occurrence of type II diabetes is highly correlated with obesity, although the mechanisms linking the two conditions are incompletely understood. Leptin is a potent insulin sensitiser and, in leptin‐deficient, insulin insensitive, Lepob/ob mice, leptin improves glucose tolerance, indicating that leptin resistance may link obesity to insulin ...
C E, Koch +5 more
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Leptin Resistance - Or Why Leptin Fails to Work in Obesity
Experimental and Clinical Endocrinology & Diabetes, 2003In experimental models of obesity high serum concentrations of leptin without subsequent inhibition of food intake indicate a resistance to the physiological effects of leptin. Similar to the animal model leptin concentrations in most of the obese patients are higher compared to normal-weight persons.
K, El-Haschimi, H, Lehnert
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Roles of leptin and resistin in metabolism, reproduction, and leptin resistance
Domestic Animal Endocrinology, 2020Increased adipose mass can cause insulin resistance and type 2 diabetes mellitus. This phenomenon is related to adipocyte-secreted signaling molecules that affect glucose balance, such as fatty acids, adiponectin, leptin, interleukin-6, tumor necrosis factor-α, and resistin.
D A, Zieba, W, Biernat, J, Barć
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Endoplasmic Reticulum Stress Induces Leptin Resistance
Molecular Pharmacology, 2008Leptin is an important circulating signal for inhibiting food intake and body weight gain. In recent years, "leptin resistance" has been considered to be one of the main causes of obesity. However, the detailed mechanisms of leptin resistance are poorly understood.
Toru, Hosoi +6 more
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Leptin resistance and hippocampal behavioral deficits
Physiology & Behavior, 2017The adipocyte-derived hormone leptin is an important regulator of body weight and metabolism through activation of brain leptin receptors expressed in regions such as the hypothalamus. Beyond these well described and characterized activities of leptin in the hypothalamus, it is becoming increasingly clear that the central activities of leptin extend to
Catherine, Van Doorn +3 more
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