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2018
Leptin is an adipocyte-derived hormone, which contributes to the homeostatic regulation of energy balance and metabolism through humoral and neural pathways. Leptin acts on the neurons in certain brain areas such as the hypothalamus, hippocampus, and brain stem to regulate food intake, thermogenesis, energy expenditure, and homeostasis of glucose/lipid
Jiarui, Liu +3 more
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Leptin is an adipocyte-derived hormone, which contributes to the homeostatic regulation of energy balance and metabolism through humoral and neural pathways. Leptin acts on the neurons in certain brain areas such as the hypothalamus, hippocampus, and brain stem to regulate food intake, thermogenesis, energy expenditure, and homeostasis of glucose/lipid
Jiarui, Liu +3 more
openaire +2 more sources
Mechanisms of Leptin Action and Leptin Resistance
Annual Review of Physiology, 2008The adipose tissue–derived hormone leptin acts via its receptor (LRb) in the brain to regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a number of other pathways is required for the totality of leptin action. The failure of elevated leptin levels to suppress feeding and mediate weight loss in common forms of obesity ...
Martin G, Myers +2 more
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Leptin, Obesity, and Leptin Resistance
2014The cloning of leptin in 1994 was an important milestone in obesity research. In those days obesity was rather stigmatized as a condition caused by lack of character and self-control. With leptin and its receptor being the first single genes that could cause morbid obesity in man and mice, it is now appreciated that obesity is caused by a dysregulation
Heike Münzberg, Steven B. Heymsfield
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Appetite, 2007
We consistently find that peripheral infusions of physiological doses of leptin inhibit lipogenesis in leptin-responsive animals. This study determined which aspect of leptin response was lost in fully and partially leptin-resistant animals. Male Wistar rats consumed a low-fat (LF, 10%) or high-fat (HF, 60%) diet for 3 months to generate diet induced ...
D.M. Penn, R.B.S Harris
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We consistently find that peripheral infusions of physiological doses of leptin inhibit lipogenesis in leptin-responsive animals. This study determined which aspect of leptin response was lost in fully and partially leptin-resistant animals. Male Wistar rats consumed a low-fat (LF, 10%) or high-fat (HF, 60%) diet for 3 months to generate diet induced ...
D.M. Penn, R.B.S Harris
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Drug targeting of leptin resistance
Life Sciences, 2015Leptin regulates glucose, lipid and energy homeostasis as well as feeding behavior, serving as a bridge between peripheral metabolically active tissues and the central nervous system (CNS). Indeed, this adipocyte-derived hormone, whose circulating levels mirror fat mass, not only exerts its anti-obesity effects mainly modulating the activity of ...
SANTORO, ANNA +2 more
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Leptin in normal physiology and leptin resistance
Science Bulletin, 2016Since the discovery of leptin as an adipokine in 1994, much progress has been made in the research about leptin. Circulating leptin binds to leptin receptor, activates STAT3-dependent and STAT3-independent signaling pathways, and plays an effective role in energy homeostasis, neuroendocrine function and metabolism mainly through acting on the central ...
Shufen Li, Xi Li
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Leptin-Signaling Pathways and Leptin Resistance
2009Leptin acts as an anorexigenic hormone in the brain, where the long form of the leptin receptor (LRb) is widely expressed in hypothalamic and extra-hypothalamic sites that are known to participate in diverse feeding circuits. The important role of leptin in energy homeostasis is demonstrated by the profound hyperphagia and morbid obesity in humans and ...
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[Leptin Signalings and Leptin Resistance].
Sheng li ke xue jin zhan [Progress in physiology], 2016Leptin plays a critical role in the regulation of energy balance and metabolic homeostasis. Impairment of leptin function is closely involved in the pathogenesis of obesity, diabetes mellitus and some other metabolic diseases. Leptin initiates intracellular signal transductions in the leptin-receptor-expressing neurons in the central nervous system to ...
Xiao-Ning, Yang +4 more
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