Results 261 to 270 of about 134,529 (291)
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2003
leptin was cloned in 1994 and shown to be secreted from adipocytes ([5][1]). This and subsequent studies demonstrated that leptin is made and secreted in proportion to the fat content of individual adipocytes ([4][2]).
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leptin was cloned in 1994 and shown to be secreted from adipocytes ([5][1]). This and subsequent studies demonstrated that leptin is made and secreted in proportion to the fat content of individual adipocytes ([4][2]).
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High‐Fat Diet Induces Leptin Resistance in Leptin‐Deficient Mice
Journal of Neuroendocrinology, 2014The occurrence of type II diabetes is highly correlated with obesity, although the mechanisms linking the two conditions are incompletely understood. Leptin is a potent insulin sensitiser and, in leptin‐deficient, insulin insensitive, Lepob/ob mice, leptin improves glucose tolerance, indicating that leptin resistance may link obesity to insulin ...
C E, Koch +5 more
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Leptin Resistance - Or Why Leptin Fails to Work in Obesity
Experimental and Clinical Endocrinology & Diabetes, 2003In experimental models of obesity high serum concentrations of leptin without subsequent inhibition of food intake indicate a resistance to the physiological effects of leptin. Similar to the animal model leptin concentrations in most of the obese patients are higher compared to normal-weight persons.
K, El-Haschimi, H, Lehnert
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Roles of leptin and resistin in metabolism, reproduction, and leptin resistance
Domestic Animal Endocrinology, 2020Increased adipose mass can cause insulin resistance and type 2 diabetes mellitus. This phenomenon is related to adipocyte-secreted signaling molecules that affect glucose balance, such as fatty acids, adiponectin, leptin, interleukin-6, tumor necrosis factor-α, and resistin.
D A, Zieba, W, Biernat, J, Barć
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Endoplasmic Reticulum Stress Induces Leptin Resistance
Molecular Pharmacology, 2008Leptin is an important circulating signal for inhibiting food intake and body weight gain. In recent years, "leptin resistance" has been considered to be one of the main causes of obesity. However, the detailed mechanisms of leptin resistance are poorly understood.
Toru, Hosoi +6 more
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Leptin resistance and hippocampal behavioral deficits
Physiology & Behavior, 2017The adipocyte-derived hormone leptin is an important regulator of body weight and metabolism through activation of brain leptin receptors expressed in regions such as the hypothalamus. Beyond these well described and characterized activities of leptin in the hypothalamus, it is becoming increasingly clear that the central activities of leptin extend to
Catherine, Van Doorn +3 more
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Improvement of Leptin Resistance
Yeungnam University Journal of Medicine, 2013Leptin, a 16-kDa cytokine, is secreted by adipose tissue in response to the surplus of fat store. Thereby, the brain is informed about the body's energy status. In the hypothalamus, leptin triggers specific neuronal subpopulations (e.g., POMC and NPY neurons) and activates several intracellular signaling events, including the JAK/STAT, MAPK, PI3K, and ...
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[Insulin resistance, role of leptin and leptin receptor].
Nihon rinsho. Japanese journal of clinical medicine, 2000Leptin, the obese gene product, is an adipocyte-derived satiety factor which is involved in the regulation of food intake and energy expenditure. Obesity often accompanies insulin resistance and high levels of leptin. In in vitro studies, leptin has been reported to increase fatty acid oxidation and decrease fatty acid synthesis in adipocytes and ...
M, Shintani, Y, Ogawa, K, Nakao
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Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward
Ca-A Cancer Journal for Clinicians, 2021Amila K Nanayakkara, Kevin Outterson
exaly
Leptin, leptin resistance and endothelial dysfunction in pre-eclampsia.
Cellular and molecular biology (Noisy-le-Grand, France), 2003Pre-eclampsia, or pregnancy-induced hypertension, is a major cause of maternal and fetal morbidity and mortality complicating 7-10% of pregnancies. Although mechanisms underlying pre-eclampsia are not well understood, endothelial dysfunction is considered to underscore many of the pre-eclamptic manifestations including hypertension, proteinuria and ...
Cindy M, Anderson, Jun, Ren
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