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A cellular and molecular basis of leptin resistance
Cell MetabolismSimilar to most humans with obesity, diet-induced obese (DIO) mice have high leptin levels and fail to respond to the exogenous hormone, suggesting that their obesity is caused by leptin resistance, the pathogenesis of which is unknown. We found that leptin treatment reduced plasma levels of leucine and methionine, mTOR-activating ligands, leading us ...
Joshua D Rabinowitz +2 more
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Leptin-Signaling Pathways and Leptin Resistance
2009Leptin acts as an anorexigenic hormone in the brain, where the long form of the leptin receptor (LRb) is widely expressed in hypothalamic and extra-hypothalamic sites that are known to participate in diverse feeding circuits. The important role of leptin in energy homeostasis is demonstrated by the profound hyperphagia and morbid obesity in humans and ...
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Leptin Resistance - Or Why Leptin Fails to Work in Obesity
Experimental and Clinical Endocrinology & Diabetes, 2003In experimental models of obesity high serum concentrations of leptin without subsequent inhibition of food intake indicate a resistance to the physiological effects of leptin. Similar to the animal model leptin concentrations in most of the obese patients are higher compared to normal-weight persons.
K, El-Haschimi, H, Lehnert
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[Leptin Signalings and Leptin Resistance].
Sheng li ke xue jin zhan [Progress in physiology], 2016Leptin plays a critical role in the regulation of energy balance and metabolic homeostasis. Impairment of leptin function is closely involved in the pathogenesis of obesity, diabetes mellitus and some other metabolic diseases. Leptin initiates intracellular signal transductions in the leptin-receptor-expressing neurons in the central nervous system to ...
Xiao-Ning, Yang +4 more
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Role of leptin and adiponectin in insulin resistance
Clinica Chimica Acta, 2013Adipose tissue is a major source of energy for the human body. It is also a source of major adipocytokines adiponectin and leptin. Insulin resistance is a condition in which insulin action is impaired in adipose tissue and is more strongly linked to intra-abdominal fat than to fat in other depots.
Amita, Yadav +3 more
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Leptin resistance and hippocampal behavioral deficits
Physiology & Behavior, 2017The adipocyte-derived hormone leptin is an important regulator of body weight and metabolism through activation of brain leptin receptors expressed in regions such as the hypothalamus. Beyond these well described and characterized activities of leptin in the hypothalamus, it is becoming increasingly clear that the central activities of leptin extend to
Catherine, Van Doorn +3 more
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2003
leptin was cloned in 1994 and shown to be secreted from adipocytes ([5][1]). This and subsequent studies demonstrated that leptin is made and secreted in proportion to the fat content of individual adipocytes ([4][2]).
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leptin was cloned in 1994 and shown to be secreted from adipocytes ([5][1]). This and subsequent studies demonstrated that leptin is made and secreted in proportion to the fat content of individual adipocytes ([4][2]).
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Improvement of Leptin Resistance
Yeungnam University Journal of Medicine, 2013Leptin, a 16-kDa cytokine, is secreted by adipose tissue in response to the surplus of fat store. Thereby, the brain is informed about the body's energy status. In the hypothalamus, leptin triggers specific neuronal subpopulations (e.g., POMC and NPY neurons) and activates several intracellular signaling events, including the JAK/STAT, MAPK, PI3K, and ...
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Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance
Frontiers in Neuroendocrinology, 2003Leptin, the long-sought satiety factor of adipocytes origin, has emerged as one of the major signals that relay the status of fat stores to the hypothalamus and plays a significant role in energy homeostasis. Understanding the mechanisms of leptin signaling in the hypothalamus during normal and pathological conditions, such as obesity, has been the ...
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[Insulin resistance, role of leptin and leptin receptor].
Nihon rinsho. Japanese journal of clinical medicine, 2000Leptin, the obese gene product, is an adipocyte-derived satiety factor which is involved in the regulation of food intake and energy expenditure. Obesity often accompanies insulin resistance and high levels of leptin. In in vitro studies, leptin has been reported to increase fatty acid oxidation and decrease fatty acid synthesis in adipocytes and ...
M, Shintani, Y, Ogawa, K, Nakao
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