Results 141 to 150 of about 392,608 (242)

Determination of the median lethal dose of zinc gluconate in mice and safety evaluation. [PDF]

BMC Pharmacol Toxicol
Wang YC, Yang X, Xiao J, Wei SM, Su Y, Chen XQ, Huang T, Shan QW.   +7 more
europepmc   +1 more source

Isopropyl-phloroglucinol-DHA protects outer retinal cells against lethal dose of all-trans-retinal. [PDF]

J Cell Mol Med, 2020
Cubizolle A, Cia D, Moine E, Jacquemot N, Guillou L, Rosell M, Angebault-Prouteau C, Lenaers G, Meunier I, Vercauteren J, Durand T, Crauste C, Brabet P.   +12 more
europepmc   +1 more source

Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis

Advanced Science, EarlyView.
Considering the great challenge in Glioblastoma multiforme (GBM) treatment, the authors designed and synthesized a multifunctional nanoplatform that effectively induced ferroptosis by synergetically inhibiting intrinsic intrisinc anti‐ferroptosis proteins, GPX4 & DHODH, and realized excellent in vitro and in vivo anti‐GBM effect.
Guodong Ren, Xuewei Wang, Panpan Li, Hao Wu, Zhifei Bi, Qi Gao, Bolong Ma, Zixuan Tian, Jianfei Liu, Fuqiang Feng, Wen Liu, Lin Li, Chengwu Zhang   +12 more
wiley   +1 more source

Extraordinary variance in meta-analysis of venom toxicity of 160 most lethal ophidians and guidelines for estimating human lethal dose range. [PDF]

J Biol Methods
Hanley BP, Gross G.
europepmc   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Acute toxicity effects of ethylene glycol on lethal dose 50 (LD₅₀), urine production, and histopathology change renal tubule cell in mice. [PDF]

Open Vet J
Meles DK, Mustofa I, Wurlina W, Donova CA, Hidayanti ER, Suwasanti N, Rosyada ZNA, Khairullah AR, Akintunde AO, Mustofa RI, Putra SW, Ahmad RZ, Wasito W, Raissa R.   +13 more
europepmc   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Lethal Dose, Clinical Signs, Gross and Microscopic Lesions Induced by <i>Aeromonas veronii</i> Biovar <i>sobria</i> A4 Strain in Experimentally Challenged Nile Tilapia (<i>Oreochromis niloticus</i>). [PDF]

Vet Med Int
Ndegwa JM, Mulei IR, Njagi LW, Nyaga PN, Wanja DW, Ali SE, Delamare-Deboutteville J.   +6 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Between a Constitutional Rock and a Procedural Hard Place: Placing Petitioners in an Eighth Amendment Battle of Persuasion [PDF]

, 2016
Nobriga, Kelley E.
core   +1 more source