Results 151 to 160 of about 234,415 (300)

Interpretation of the shoulder of dose-response curves with immediate plating in terms of repair of potentially lethal lesions during a restricted time period.

open access: yes, 1981
It is shown theoretically that a shouldered dose-response curve may be obtained when repair of Poisson-distributed potentially lethal lesions occurs during a restricted time period between plating irradiated cells on nutrient agar and fixation of ...
Frankenberg, D.   +1 more
core   +1 more source

A Plate Based Assay for Determination of the Median Lethal Dose of 1-Hydroxyphenazine in Caenorhabditis elegans. [PDF]

open access: yesMicroPubl Biol, 2021
Asif MZ   +5 more
europepmc   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

open access: yesAdvanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He   +10 more
wiley   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

open access: yesAdvanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott   +5 more
wiley   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

open access: yesAdvanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng   +11 more
wiley   +1 more source

Carbon-ion radiation biological lethal dose distribution [PDF]

open access: yes, 2018
2018 Summer.Includes bibliographical references.Background: Carbon-ion radiotherapy is an emerging modality used in cancer therapy. It has been very successful in treating solid cancers due to its excellent physical dose-distribution and deposition ...
Legare, Marie, committee member   +3 more
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

open access: yesAdvanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang   +6 more
wiley   +1 more source

Lethal dose and clinical signs of Streptococcus agalactiae in Javanese medaka (Oryzias javanicus Bleeker 1854) [PDF]

open access: yes, 2016
This study was conducted to determine the lethal dose and clinical signs of Streptococcus agalactiae in Javanese medaka. Javanese medaka was collected in Sungai Pelek, Sepang and brought to the laboratory for acclimatization.
Nasruddin, Nurrul Shaqinah   +4 more
core  

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