Results 201 to 210 of about 212,718 (244)

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Evaluating the impact of nitisinone at mosquito-lethal doses on Lutzomyia longipalpis. [PDF]

PLoS Negl Trop Dis
Augendre L, Alexandre Farias de Souza L, Costa Ribeiro MCVD, Depaquit J, Martinet JP, Prudhomme J.   +5 more
europepmc   +1 more source

Transfer of anti-Klebsiella pneumoniae immunity following infection in mice is protective against lethal challenge in offspring. [PDF]

Sci Rep
Mason E, Winter K, Liang J, Hakimpour S, Patel R, Harn T, Chu KH, Shulha H, Cai B, Lo M, Sadarangani M.   +10 more
europepmc   +1 more source

Near-UVA Radiation at 405 nm: Germicidal Effect With and Without Sub-Lethal Conditions on Gram-Positive and Gram-Negative Bacteria. [PDF]

Pathogens
Amodeo D, Pedrazzoli G, Palma I, Puccio A, Trillocco G, Papale G, Cevenini G, Tani M, Messina G.   +8 more
europepmc   +1 more source

Chimeric Antibody Engineering Against Bacillus anthracis Lethal Toxin: Neutralization Efficacy and Mechanism of Action. [PDF]

Toxins (Basel)
Kalmantaeva OV, Marin MA, Ershova AA, Ryabko AK, Romanenko YO, Kombarova TI, Dyatlov IA, Firstova VV.   +7 more
europepmc   +1 more source

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Doctors admit lethal doses administered

Nursing Standard, 1991
Doctors admitted they had administered lethal drug doses at patients' requests in 1.8 per cent of deaths studied in a survey in the Netherlands.
openaire   +2 more sources

ROBUST ESTIMATION OF THE MEDIAN LETHAL DOSE

Journal of Biopharmaceutical Statistics, 2002
Alternatives to M-estimation for robust estimation of the median lethal dose in biological assays are developed. A class of link functions based on the Student-t distribution is proposed, where degrees of freedom are estimated from the data by maximum likelihood. Other alternatives include slash and finite mixture distributions.
G E, Kelly, J K, Lindsey
openaire   +2 more sources

Approximate lethal dose versus median lethal dose in acute toxicity testing of pharmaceuticals

Archives of Toxicology, 1989
The relation between approximate lethal doses (ALD, i.e. the lowest dose at which mortality occurs) and the corresponding median lethal doses (LD50) was investigated in 231 acute toxicity studies in mice and rats. The ALD values were divided into four classes (less than 5 mg/kg, 5-50 mg/kg, 50-500 mg/kg, 500-2000 mg/kg) and the LD50/ALD factors were ...
openaire   +2 more sources

Interval Estimation of the Median Lethal Dose

Biometrics, 1986
Assuming a logistic dose-response curve, one can construct a confidence interval for the LD50 from the asymptotic likelihood ratio test. Reasons are given for preferring this likelihood ratio interval to the established interval calculated by applying Fieller's theorem to the maximum likelihood estimates.
openaire   +3 more sources

A Lethal Dose of RNA

Science, 2013
A new generation of genetically modified crops will kill insects by silencing their genes.
openaire   +1 more source