Results 211 to 220 of about 212,718 (244)
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Stochastic duels with lethal dose
Naval Research Logistics Quarterly, 1970This paper introduces the idea of lethal dose to achieve a kill and examines its effect on the course and final outcome of a duel. Results have been illustrated for a particular case of exponential firing rates.
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Lethal catatonia responding to high-dose olanzapine therapy
Journal of Psychopharmacology, 2001We present the case of a 31-year-old woman with recent refractory bipolar disorder who developed a malignant syndrome preceded by catatonic motor features. This resistant case of lethal catatonia responded selectively to high-dose olanzapine treatment.
Cassidy, E M +4 more
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The median lethal dose and its estimation
Archives of Toxicology, 1985An important paper by Zbinden and Fluri-Roversi (1981) has shown the many weaknesses in any policy or regulatory system that regards an estimated LD50 in an animal species as an adequate guide to toxicity in man. The present paper draws attention to some statistical aspects of LD50 estimation that are too often neglected or misunderstood when this ...
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Supra-lethal dose—a concept never explained
International Journal of Radiation Oncology*Biology*Physics, 1976Tumor lethal dosage, Optimum dose, Supra-iethal effect. For many years the radiotherapist has been primarily concerned with the relationship between tumor lethal dosage, normal tissue tolerante and acceptable levels of morbidity, or what is considered an “optimum dose”, a concept which correlates total dose, number of fractions, overall-time, volume ...
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maximum non-lethal dose (MNLD)
2009Highest single dose which does not induce death in animals; has replaced calculation of LD-50?? values.
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Protecting Liver From Painkiller's Lethal Dose
Science, 2002TOXICOLOGYOverdoses of the painkiller acetaminophen can cause severe, sometimes fatal liver damage. New results, reported on page [422][1] of this issue, help explain just how acetaminophen harms the liver. They may also provide a target for treating liver failure due to overdoses of acetaminophen and perhaps of other drugs as well.
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Toxicity of Histamine: Lethal Doses
1966For a substance, such as histamine, whose normal physiological role has not been completely established (Feldberg, 1954; Gaddum, 1948; Jancso, 1947; Kahlson, 1960; Parrot and Reuse, 1954; Rocha e Silva, 1955; Schayer, 1961), it is difficult to delimit when the effects should be considered toxic.
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Hypothermia Against Lethal Dose of Mechlorethamine
Archives of Surgery, 1961One of the problems involved in regional perfusion for cancer chemotherapy is protection of the bone marrow outside of the perfused area due to "leak" of the antitumor agent from the perfused area. Since in vitro experiments have shown that reduction in incubation temperature below 37 C depresses the antitumor effect of certain alkylating agents ...
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Lethal Dose Studies with X-Rays
Radiology, 1945I. IntroductionBiological evaluation is as indispensable in study of the therapeutic potentiality of radiations as in that of drugs, hormones, or vitamins. This is particularly true of radiations of short wave length, such as x-rays, which are known to produce permanent and irreversible changes.It is well known that there are two fundamentals upon ...
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