Acute Toxicity (Lethal Dose 50 Calculation) of Herbal Drug Somina in Rats and Mice
Pharmacology & Pharmacy, 2015 Somina (herbal preparation) prepared by Hamdard Laboratories (Waqf) Pakistan is a mixture of five different medicinal plants, widely prescribed for the treatment of mental illness. For acute toxicity, the Karber arithmetic method for the calculation of LD50 and Hodge and Sterner toxicity scale was used. In this study, different doses (10, 100, 285, 500,
Muhammad Ahmed
semanticscholar +4 more sources
Effect of Linezolid on the 50% Lethal Dose and 50% Protective Dose in Treatment of Infections by Gram-Negative Pathogens in Naive and Immunosuppressed Mice and on the Efficacy of Ciprofloxacin in an Acute Murine Model of Septicemia [PDF]
Antimicrobial Agents and Chemotherapy, 2012 ABSTRACTMurine models of infection were used to study the effect of linezolid on the virulence of Gram-negative bacteria and to assess potential pharmacodynamic interactions with ciprofloxacin in the treatment of these infections, prompted by observations from a recent clinical trial.
Andrea Marra +8 more
semanticscholar +4 more sources
Determination of the lethal dose 50% (LD50) of cadmium chloride and the histopathological changes in male mice liver and kidneys [PDF]
Journal of Education and Science, 2012 The lethal dose 50 (LD50) test involves the administration of cadmium in the form of CdCl2 to group of animals at an increasing dose in order to determine the dose that kills 50 percent of the test mice within a set of time frame (24 and 48h).
Talib Hussen Ali
semanticscholar +4 more sources
The new algorithm for calculation of median lethal dose (LD50) and effective dose fifty (ED50) of Micrarus fulvius venom and anti-venom in mice [PDF]
International Journal of Veterinary Science and Medicine, 2016 Background One million people throughout the world are bitten each year by poisonous snakes. Of this, one‐tenth died and three‐tenth suffer some forms of disabilities. In view of this, anti‐snake venoms are currently being developed against viper and colubrid snake venoms using mice.
Saganuwan Alhaji Saganuwan
openalex +4 more sources
Electronic Journal of Plant Breeding, 2016 An experiment was conducted to estimate the lethal dose of the physical mutagen gamma ray in Kodomillet variety CO 3. Genetically pure seeds were treated with different doses of gamma rays viz., 100 Gy, 200 Gy, 300 Gy, 400 Gy and 500 Gy.
J Poornima Jency +3 more
doaj +2 more sources
Determination of Lethal Dose 50 for Induced Mutagenesis in Soybean [Glycine max (L.) Merril] cv. Gepak Kuning Through Ethyl Methane Sulfonate Mutagen [PDF]
Agricultural Science Digest - A Research Journal, 2023 Background: The improvement of the genetic and agronomic properties of cultivated plants can be carried out by various plant breeding methods, including mutation breeding. Mutations in nature are very few and rare. Ethyl Methane Sulfonate (EMS) is a chemical mutagen that can cause random mutations resulting in changes in genetic material.
Nilahayati Nilahayati +5 more
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Prediction of Human Lethal Doses and Concentrations of MEIC Chemicals from Rodent LD50 Values: An Attempt to Make Some Reparation [PDF]
Alternatives to Laboratory Animals, 2021 The prediction of human toxicities from animal toxicity tests is often poor, and is now discouraged and in some cases banned, especially those involving the LD50 test. However, there is a vast number of historical LD50 data in both public and in-house repositories that are being put to little use.
John C. Dearden, Mark Hewitt
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Lethal dose 50 and the first-generation mutant of upland purple rice cultivar Med Fai 62 [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2023 Inducing mutations is a breeding tool that creates genetic variability. In this study of inducing mutations in the Indica upland purple rice cultivar Med Fai 62 with mutagenic Ethyl Methane Sulfonate (EMS), a completely randomized experimental design ...
Nucharee Chadakan +2 more
doaj +1 more source
Alternative Methods for the Median Lethal Dose (LD50) Test: The Up-and-Down Procedure for Acute Oral Toxicity [PDF]
ILAR Journal, 2002 The authors have developed an improved version of the up-and-down procedure (UDP) as one of the replacements for the traditional acute oral toxicity test formerly used by the Organisation for Economic Co-operation and Development member nations to characterize industrial chemicals, pesticides, and their mixtures. This method improves the performance of
Amy, Rispin +8 more
openaire +3 more sources
Determination of acute lethal dose 50 (LD50) of uranyl nitrate in male swiss albino mice
Research Journal of Pharmacy and Technology, 2018 Evaluation of LD50 is the foremost step in the assessment of toxicity of a substance. The present study was designed to determine the acute LD50 of uranyl nitrate via intraperitoneal route in male swiss albino mice. The selected single doses of uranyl nitrate from the pilot study conducted were 64, 32, 16, 8, 4mg/kg bdwt.
Sangeetha P. Vijayan +3 more
openalex +2 more sources