Results 121 to 130 of about 120,091 (334)

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Microenvironment Modulation‐Based Nanomaterial‐Loaded Hydrogel Dressings for Diabetic Foot Ulcers: Research Progress and Future Perspectives

Advanced Materials Interfaces, EarlyView.
xx xx. ABSTRACT Diabetic foot ulcer (DFU) is a chronic complication of diabetes, primarily caused by hyperglycemia, peripheral vascular disease, and neuropathy. Characterized by persistent hyperglycemia, impaired perfusion, inflammation, and infection, DFUs pose significant challenges to healing and are associated with high morbidity and amputation ...
Tang Yuqing, Chen Hong, Fan Weijing, Huang Renyan, You Yang, Liu Guobin   +5 more
wiley   +1 more source

Anthrax toxin receptor drives protective antigen oligomerization and stabilizes the heptameric and octameric oligomer by a similar mechanism.

PLoS ONE, 2010
BackgroundAnthrax toxin is comprised of protective antigen (PA), lethal factor (LF), and edema factor (EF). These proteins are individually nontoxic; however, when PA assembles with LF and EF, it produces lethal toxin and edema toxin, respectively ...
Alexander F Kintzer, Harry J Sterling, Iok I Tang, Evan R Williams, Bryan A Krantz   +4 more
doaj   +1 more source

Temperature‐Dependent Zinc Oxide Cathodoluminescence: Toward Compact Wavelength‐Tunable Solid‐State Photoionization Sources

Advanced Optical Materials, EarlyView.
A proof‐of‐concept of a thermally‐tunable cathodoluminescence‐based light source is demonstrated using a wide‐bandgap z‐cut ZnO crystal as anode, resulting in the ultraviolet (UV) emission peak shifting from 398 nm to ~409 nm (3.115‐3.032 eV). Our results establish the feasibility of a compact, field‐deployable UV source with potential for gas sensing ...
Rui M. R. Pinto, Aritz Retolaza, João Cunha, Pedro Matos, Júlio Silva, Diana Silva, Rosana Alves Dias, K. B. Vinayakumar   +7 more
wiley   +1 more source

Human monoclonal anti-protective antigen antibody for the low-dose post-exposure prophylaxis and treatment of Anthrax

BMC Infectious Diseases, 2018
Background Disease caused by Bacillus anthracis is often accompanied by high mortality primarily due to toxin-mediated injury. In the early disease course, anthrax toxins are secreted; thus, antibiotic use is limited to the early stage.
Qi Tang, Siping Xiong, Xudong Liang, Xingwang Kuai, Yiwen Wang, Changjun Wang, Zhenqing Feng, Jin Zhu   +7 more
doaj   +1 more source

Persistent bacteremia and psoas abscess caused by a lethal toxin-deficient Paeniclostridiumsordellii. [PDF]

Anaerobe, 2022
Varley CD, Rogers LM, Dixon BR, Bernard SC, Lacy DB, Sulpizio E, Aronoff DM, Townes JM.   +7 more
europepmc   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Differentiation of Clostridium difficile Toxin from Clostridium botulinum Toxin by the Mouse Lethality Test [PDF]

, 1983
Peter H. Gilligan, Lawrence W. Brown, Richard E. Berman   +2 more
openalex   +1 more source

Long‐Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury

Advanced Science, EarlyView.
Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti, Edwige Rice, Franck Desmoulin, Maylis Combeau, Mélissa Parny, Lorenne Robert, Etienne Buscail, Barbara Bournet, Nathalie Vergnolle, Isabelle Raymond‐Letron, Isabelle Loubinoux, Carla Cirillo   +11 more
wiley   +1 more source

Pathogenetic Grounds of Principles of Depotentiation of Lethal Effects Y. pestis toxins

Проблемы особо опасных инфекций, 2012
Lethal combination of lypoplyssacharide and mouse Y. pestis toxin is decreased by the use of effective preparation - Cytoflavinum, the antihypoxant of substrate and regulatory activity.
G. A. Afanas'eva, N. P. Chesnokova
doaj   +1 more source