Results 121 to 130 of about 94,541 (354)
Essential plasticity and redundancy of metabolism unveiled by synthetic lethality analysis [PDF]
, 2013 We unravel how functional plasticity and redundancy are essential mechanisms underlying the ability to survive of metabolic networks. We perform an exhaustive computational screening of synthetic lethal reaction pairs in Escherichia coli in a minimal medium and we find that synthetic lethal pairs divide in two different groups depending on whether the ...
arxiv +1 more source
Rethinking the role of alpha toxin in Clostridium perfringens-associated enteric diseases : a review on bovine necro-haemorrhagic enteritis [PDF]
, 2017 Bovine necro-haemorrhagic enteritis is an economically important disease caused by Clostridium perfringens type A strains. The disease mainly affects calves under intensive rearing conditions and is characterized by sudden death associated with small ...
Deprez, Piet +6 more
core +3 more sources
Salt‐Compact Albumin as a New Pure Protein‐based Biomaterials: From Design to In Vivo Studies
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.A new class of materials built entirely of native albumin protein is designed using a simple protocol based on salt‐assisted compaction, breaking with current crosslinking strategies. This green process leads, surprisingly, to water‐insoluble handable materials with high preservation of their native protein structures and Young's modulus close to that ...
Eya Aloui +19 more
wiley +1 more source
Introduction to the Toxins Special Issue “Ricin Toxins”
Toxins, 2019 Ricin toxin isolated from the castor bean (Ricinus communis) is one of the most potent and lethal molecules known [...]
Nilgun E. Tumer
doaj +1 more source
The Dynamic Behavior (Effects) of Impulsive Toxicant Input on a Single-Species Population in a Small Polluted Environment [PDF]
arXiv, 2016 In this paper, we study a single-species population model with pulse toxicant input to a small polluted environment. The intrinsic rate of population is affected by environment and toxin in organisms. The toxin in organisms is influenced by toxin in environment and the food chain. A new mathematical model is derived.
arxiv
Measurement of Botulinum Toxin Activity: Evaluation of the Lethality Assay
Toxicology and Applied Pharmacology, 1994 The use of the mouse lethality assay for the estimation of the biologic activity of botulinum toxin was evaluated. The relationship between the number of animals, number of doses, and duration of the assay used to estimate the LD50 and the precision of the assay was investigated.
E R First +3 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.This proof‐of‐concept study involves high‐throughput teratogenicity screening of compounds using XEn/EpiCs, a 3D stem cell‐based embryo model, within microwells. The term ‘morphotoxicity’ is introduced to complement traditional cytotoxicity assays through automated feature extraction and machine‐learning‐assisted classification of morphologies.
Vinidhra Shankar +4 more
wiley +1 more source
Lethality and synthetic lethality in the genome-wide metabolic network of Escherichia coli [PDF]
J. Theor. Biol. 237, 401 (2005), 2004 Recent genomic analyses on the cellular metabolic network show that reaction flux across enzymes are diverse and exhibit power-law behavior in its distribution. While one may guess that the reactions with larger fluxes are more likely to be lethal under the blockade of its catalyzing gene products or gene knockouts, we find, by in silico flux analysis,
arxiv
Structural dynamics of the CROPs domain control stability and toxicity of Paeniclostridium sordellii lethal toxin. [PDF]
Nat Commun, 2023 Zhou Y +11 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.To suppress uveal melanoma metastasis (UM), the GSH‐responsive polymer named NP@Oxa/Criz has been successfully prepared. NP@Oxa/Criz selectively accumulates in UM tumors, targeting HGF/c‐Met Axis to undermine the stemness and metastasis of UM while triggering immunogenic cell death through DAMPs release to boost anti‐tumor immunity.
Hui Tao +8 more
wiley +1 more source