Gene-trap mutagenesis identifies mammalian genes contributing to intoxication by Clostridium perfringens ε-toxin. [PDF]
PLoS ONE, 2011 The Clostridium perfringens ε-toxin is an extremely potent toxin associated with lethal toxemias in domesticated ruminants and may be toxic to humans. Intoxication results in fluid accumulation in various tissues, most notably in the brain and kidneys ...
Susan E Ivie +4 more
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Role of Cytolethal Distending Toxin in Altered Stool Form and Bowel Phenotypes in a Rat Model of Post-infectious Irritable Bowel Syndrome. [PDF]
, 2012 Background/aimsCampylobacter jejuni infection is a leading cause of acute gastroenteritis, which is a trigger for post-infectious irritable bowel syndrome (PI-IBS). Cytolethal distending toxin (CDT) is expressed by enteric pathogens that cause PI-IBS. We
Alpern, Joel +12 more
core +1 more source
Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis. [PDF]
PLoS ONE, 2010 Clostridium difficile toxin A (TcdA) and toxin B (TcdB), C. sordellii lethal toxin (TcsL) and C. novyi alpha-toxin (TcnA) are important pathogenicity factors, which represent the family of the clostridial glucosylating toxins (CGTs).
Panagiotis Papatheodorou +4 more
doaj +1 more source
Transcriptional cellular responses in midgut tissue of Aedes aegypti larvae following intoxication with Cry11Aa toxin from Bacillus thuringiensis. [PDF]
, 2015 BackgroundAlthough much is known about the mechanism of action of Bacillus thuringiensis Cry toxins, the target tissue cellular responses to toxin activity is less understood.
Bravo, Alejandra +4 more
core +1 more source
A Replicating Single-Cycle Adenovirus Vaccine Effective against Clostridium difficile
Vaccines, 2020 Clostridium difficile causes nearly 500,000 infections and nearly 30,000 deaths each year in the U.S., which is estimated to cost $4.8 billion. C. difficile infection (CDI) arises from bacteria colonizing the large intestine and releasing two toxins ...
William E. Matchett +8 more
doaj +1 more source
Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins. [PDF]
, 2019 Dinoflagelates and cyanobacteria produce saxitoxin (STX), a lethal bis-guanidinium neurotoxin causing paralytic shellfish poisoning. A number of metazoans have soluble STX-binding proteins that may prevent STX intoxication.
Du Bois, J +4 more
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Small molecule inhibitors of anthrax lethal factor toxin [PDF]
Bioorganic & Medicinal Chemistry, 2014 This manuscript describes the preparation of new small molecule inhibitors of Bacillus anthracis lethal factor. Our starting point was the symmetrical, bis-quinolinyl compound 1 (NSC 12155). Optimization of one half of this molecule led to new LF inhibitors that were desymmetrized to afford more drug-like compounds.
John D, Williams +5 more
openaire +2 more sources
Frontiers in Microbiology, 2016 Shiga toxin producing Escherichia coli may damage the central nervous system before or concomitantly to manifested hemolytic uremic syndrome symptoms.
Luciana eD’Alessio +6 more
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Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]
, 2015 Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa +6 more
core +2 more sources
Tumor Targeting and Drug Delivery by Anthrax Toxin
Toxins, 2016 Anthrax toxin is a potent tripartite protein toxin from Bacillus anthracis. It is one of the two virulence factors and causes the disease anthrax.
Christopher Bachran, Stephen H. Leppla
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