Gene-trap mutagenesis identifies mammalian genes contributing to intoxication by Clostridium perfringens ε-toxin. [PDF]
PLoS ONE, 2011 The Clostridium perfringens ε-toxin is an extremely potent toxin associated with lethal toxemias in domesticated ruminants and may be toxic to humans. Intoxication results in fluid accumulation in various tissues, most notably in the brain and kidneys ...
Susan E Ivie +4 more
doaj +1 more source
Interactive effects of multiple stressors in coastal ecosystems [PDF]
arXiv, 2023 Coastal ecosystems are increasingly experiencing anthropogenic pressures such as climate heating, CO2 increase, metal and organic pollution, overfishing and resource extraction. Some resulting stressors are more direct like fisheries, others more indirect like ocean acidification, yet they jointly affect marine biota, communities and entire ecosystems.
arxiv
Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropods [PDF]
, 2017 Peer reviewedPublisher ...
EFSA Panel on Contaminants in the Food Chain (CONTAM)
core +1 more source
Anthrax Lethal Toxin and the Induction of CD4 T Cell Immunity [PDF]
Toxins, 2012 Bacillus anthracis secretes exotoxins which act through several mechanisms including those that can subvert adaptive immunity with respect both to antigen presenting cell and T cell function. The combination of Protective Antigen (PA) and Lethal Factor (LF) forming Lethal Toxin (LT), acts within host cells to down-regulate the mitogen activated protein
Ascough, Stephanie +2 more
openaire +5 more sources
Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis. [PDF]
PLoS ONE, 2010 Clostridium difficile toxin A (TcdA) and toxin B (TcdB), C. sordellii lethal toxin (TcsL) and C. novyi alpha-toxin (TcnA) are important pathogenicity factors, which represent the family of the clostridial glucosylating toxins (CGTs).
Panagiotis Papatheodorou +4 more
doaj +1 more source
A molecular target for viral killer toxin: TOK1 potassium channels. [PDF]
, 1999 Killer strains of S. cerevisiae harbor double-stranded RNA viruses and secrete protein toxins that kill virus-free cells. The K1 killer toxin acts on sensitive yeast cells to perturb potassium homeostasis and cause cell death. Here, the toxin is shown to
Ahmed, A +5 more
core +1 more source
Chapter 9 Gene Drive Strategies for Population Replacement [PDF]
, 2016 Gene drive systems are selfish genetic elements capable of spreading into a population despite a fitness cost. A variety of these systems have been proposed for spreading disease-refractory genes into mosquito populations, thus reducing their ability to ...
Akbari, Omar S, Marshall, John M
core +1 more source
Frontiers in Microbiology, 2016 Shiga toxin producing Escherichia coli may damage the central nervous system before or concomitantly to manifested hemolytic uremic syndrome symptoms.
Luciana eD’Alessio +6 more
doaj +1 more source
Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics
Toxins, 2023 Anthrax toxin is a critical virulence factor of Bacillus anthracis. The toxin comprises protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF), forming bipartite lethal toxin (LT) and edema toxin (ET).
Weiming Ouyang +3 more
doaj +1 more source
Tumor Targeting and Drug Delivery by Anthrax Toxin
Toxins, 2016 Anthrax toxin is a potent tripartite protein toxin from Bacillus anthracis. It is one of the two virulence factors and causes the disease anthrax.
Christopher Bachran, Stephen H. Leppla
doaj +1 more source