Estrogen Deprivation During Primate (Papio anubis) Pregnancy: Impact on Systemic Microvascular Flow and Cardiovascular Development and Function After Birth in Offspring. [PDF]
J Med PrimatolABSTRACT Background Suppressing estradiol (E2) during baboon pregnancy lowers offspring skeletal muscle capillary density, vital for insulin‐mediated glucose uptake, and induces insulin resistance. We examined whether E2 deprivation also impairs microvascular flow and cardiac function.
Turan S +4 more
europepmc +2 more sources
Palbociclib has no clinically relevant effect on the QTc interval in patients with advanced breast cancer. [PDF]
, 2018 The aim of this study was to assess the potential effects of palbociclib in combination with letrozole on QTc. PALOMA-2, a phase 3, randomized, double-blind, placebo-controlled trial, compared palbociclib plus letrozole with placebo plus letrozole in ...
Durairaj, Chandrasekar +12 more
core +2 more sources
BMC Pregnancy and Childbirth, 2022 Background Letrozole treatment is considered an effective option in endometrial preparation for frozen embryo transfers in patients with ovulation disorders or irregular menstruation; however, the effectiveness of letrozole-induced endometrial ...
Kenji Ezoe +4 more
doaj +1 more source
Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome. [PDF]
, 2019 Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive-aged women that is comprised of two out of the following three features: hyperandrogenism, oligo- or amenorrhea, or polycystic ovaries. In addition to infertility, many women
Arroyo, Pablo +4 more
core +2 more sources
Neoadjuvant endocrine therapy for luminal breast cancer treatment: a first-choice alternative in times of crisis such as the COVID-19 pandemic [PDF]
, 2020 The epidemiological emergency caused by CoV-2 (COVID-19) has changed priorities in breast cancer management. In those places where the pandemic has had the greatest effect, it is of paramount importance for most patients to be at home, reducing or ...
Martí, Covadonga +1 more
core +1 more source
Indonesian Journal of Obstetrics and Gynecology, 2012 Objective: To compare the effects of ovulation induction with 2.5 mg letrozole to 5 mg letrozole by the number of mature follicles, endometrial morphology and endometrium thickness during the late follicular phase in infertility patient who successfully ...
Anita Tobing
doaj +1 more source
TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione [PDF]
, 2016 Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of ...
Benemei, Silvia +15 more
core +1 more source
Reproductive Health, 2020 Background Letrozole can significantly decrease the estrogen level, and has been administrated to prevent the incidence of early ovary hyperstimulation syndrome (OHSS).
Jing Zhao +4 more
doaj +1 more source
Journal of Ovarian Research, 2022 Background Letrozole has been reported to be effective in treating anovulation, preventing ovarian hyperstimulation syndrome (OHSS), and retrieving oocytes in breast cancer patients.
Fukiko Kasuga-Yamashita +10 more
doaj +1 more source
Comparison of Treatment Outcomes of Infertile Women by Clomiphene Citrate and Letrozole with Gonadotropins Underwent Intrauterine Insemination [PDF]
Acta Medica Iranica, 2012 This study was designed to compare the effect of clomiphene and letrozole in ovulatory stimulation in infertile women under intrauterine insemination who referred to Mahdiyeh infertility clinic during 2008-2009.
Shahrzad Zadehmodares +4 more
doaj +1 more source