Results 21 to 30 of about 6,250 (152)

Letrozole increases preantral follicle growth and decreases estradiol production without impairing follicle survival

Journal of Ovarian Research, 2022
Background Letrozole has been reported to be effective in treating anovulation, preventing ovarian hyperstimulation syndrome (OHSS), and retrieving oocytes in breast cancer patients.
Fukiko Kasuga-Yamashita, Tsuyoshi Baba, Sachiko Nagao, Yuya Fujibe, Miyuki Morishita, Yoshika Kuno, Tasuku Mariya, Hiroyuki Honnma, Toshiaki Endo, Tamotsu Kiya, Tsuyoshi Saito   +10 more
doaj   +1 more source

Comparison of Treatment Outcomes of Infertile Women by Clomiphene Citrate and Letrozole with Gonadotropins Underwent Intrauterine Insemination [PDF]

Acta Medica Iranica, 2012
This study was designed to compare the effect of clomiphene and letrozole in ovulatory stimulation in infertile women under intrauterine insemination who referred to Mahdiyeh infertility clinic during 2008-2009.
Shahrzad Zadehmodares, Mahnaz Niyakan, Seyede Afsar Sharafy, Maryam Hosseinnezhad Yazdi, Fatemeh Jahed   +4 more
doaj   +1 more source

Effect of Letrozole on hippocampal Let-7 microRNAs and their correlation with working memory and phosphorylated Tau protein in an Alzheimer's disease-like rat model

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022
Background Let-7 microRNAs (miRNAs) may contribute to neurodegeneration, including Alzheimer's disease (AD), but, they were not investigated in Streptozotocin (STZ)-induced AD.
Nada Alaa Moustafa, Mohammed Abdelhamed El-Sayed, Somia Hassan Abdallah, Noha Mohamed Hazem, Magdy Abdelhamed Aidaros, Doaa Attia Abdelmoety   +5 more
doaj   +1 more source

A preliminary study of sex differences and histopathological observations in experimentally-induced Alzheimer’s disease albino rats with Letrozole administration [PDF]

Zagazig University Medical Journal
Background: Letrozole is an aromatase inhibitor with conflicting studies reporting its effects on memory in male and female animals, and whether the observed memory impairments become exacerbated with an additional insult such as Alzheimer's disease (AD);
Doaa Abdelmoety, Mohammed El-Sayed, Somia Abdallah, Nada Moustafa   +3 more
doaj   +1 more source

Letrozole plus misoprostol versus misoprostol alone in the induction of anembryonic missed abortion: a randomized controlled trial conducted in Upper Egypt

Middle East Fertility Society Journal, 2023
Background A missed abortion is a spontaneous abortion in which the embryo or fetus has already died but has remained in the uterus for days or weeks with a closed cervical ostium.
Ramy Heshmat Zekry Tadros, Usama Fouda, Sherif Sameh Zaki, Marwa Abdalla   +3 more
doaj   +1 more source

Impact of 2.5 mg versus 5 mg letrozole co-treatment in an antagonist protocol for IVF: a retrospective study

Frontiers in Endocrinology, 2023
ObjectiveThe present study aimed to compare the effectiveness of two different doses of letrozole (2.5 mg and 5 mg daily) in an antagonist protocol for infertile women with normal ovarian reserve.MethodsThis retrospective cohort study included infertile ...
Jing Lin, Fenglu Wu, Kai Zhang, Yanwen Zhu, Bian Wang, Qianqian Zhu, Jiaying Lin   +6 more
doaj   +1 more source

Low dose-extended letrozole versus double dose-short letrozole protocol for ovulation induction in polycystic ovary syndrome [PDF]

, 2022
Background: Letrozole, an aromatase inhibitor has been regarded as the first line drug for ovulation induction in anovulatory PCOS patients because of its monofollicular growth and there is no chance of hyperstimulation by letrozole. Traditional protocol
Nazneen, Sohely, Banu, Jesmine, Ishrat, Shakeela, Jahan, Nishat, Rani, Chalontika, Akter, Sumaiya, Jahan, Shirin, Deeba, Farzana   +7 more
core   +1 more source

Global expression response of genes in sex-undifferentiated Nile tilapia gonads after exposure to trace letrozole

Ecotoxicology and Environmental Safety, 2021
The aromatase inhibitor letrozole can be found in rivers, effluents, and even drinking water. Studies have demonstrated that letrozole affects various metabolic pathways and may cause reproductive toxicity, especially in fish exposed during development ...
Jian Teng, Yan Zhao, Hong Ju Chen, Liang Yi Xue, Xiang Shan Ji   +4 more
doaj   +1 more source

Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers [PDF]

, 2013
Introduction: We examined if a combination of proliferation markers and estrogen receptor (ER) activity could predict early versus late relapses in ER-positive breast cancer and inform the choice and length of adjuvant endocrine therapy.
Luca Gianni, Del Conte, Gianluca, Sotiriou, Christos, Pusztai, Lajos, Lajos Pusztai, Karn, Thomas, Symmans, W. Fraser, Libero Santarpia, Volkmar Müller, Santarpia, Libero, Sven Becker, Milvia Zambetti, Müller, Volkmar, Symmans, W Fraser, Benjamin Haibe-Kains, Kelly, Catherine M, Rody, Achim, Catherine M Kelly, Giampaolo Bianchini, Marcus Schmidt, Gianluca Del Conte, Gianni, Luca, Bianchini, Giampaolo, W Fraser Symmans, Haibe-Kains, Benjamin, Thomas Karn, Achim Rody, Schmidt, Marcus, Fasolo, Angelica, Takayuki Iwamoto, Angelica Fasolo, Holtrich, Uwe, Kelly, Catherine M., Yuan Qi, Christos Sotiriou, Uwe Holtrich, Iwamoto, Takayuki, Qi, Yuan, Becker, Sven, Zambetti, Milvia   +39 more
core   +2 more sources

Matching-adjusted indirect comparison of PFS and OS comparing ribociclib plus letrozole palbociclib plus letrozole as first-line treatment of HR+/HER2− advanced breast cancer

Therapeutic Advances in Medical Oncology, 2023
Background: Current standard-of-care first-line treatment of patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2−) advanced breast cancer (ABC) is cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) + endocrine
Komal Jhaveri, Joyce O’Shaughnessy, Peter A. Fasching, Sara M. Tolaney, Denise A. Yardley, Vikash Kumar Sharma, Chandroday Biswas, Astrid Thuerigen, Purnima Pathak, Hope S. Rugo   +9 more
doaj   +1 more source