Results 31 to 40 of about 20,646 (210)

Pharmacokinetic Evaluation of a Cinnamon Product on CYP2A6 Substrate Drugs: Application of a Novel Tool Involving the Nicotine Metabolite Ratio. [PDF]

Clin Pharmacol Ther
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5‐fold increase in the AUC of the CYP2A6 substrates nicotine and letrozole.
Nguyen AP, Hadi DL, Todd DA, Manwill PK, White JR, Layton ME, Cech NB, Thummel KE, Paine MF.   +8 more
europepmc   +2 more sources

The Differences of Folliculogenesis between Treated with Letrozole and Letrozole-Electroacupuncture in Women with Polycystic Ovary Syndrome [PDF]

, 2020
Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder that most often causes infertility. It occurs due to the failure of folliculogenesis, thus causing non-ovulation.
Budihastuti, Uki Retno, Yulyanti, Yulyanti, Melinawati, Eriana, Sulistyowati, Sri, Nurwati, Ida   +4 more
core   +1 more source

A prospective randomized trial comparing the efficacy of Letrozole and Clomiphene citrate in induction of ovulation in polycystic ovarian syndrome

Journal of Human Reproductive Sciences, 2012
Objectives: To compare the efficacy of letrozole and clomiphene citrate (CC) in patients of anovulatory polycystic ovarian syndrome (PCOS) with infertility.
Kallol Kumar Roy, Jinee Baruah, Shilpa Singla, Jai Bhagwan Sharma, Neeta Singh, Sunesh Kumar Jain, Manu Goyal   +6 more
doaj   +1 more source

Effect of letrozole and raloxifene on in vitro human endometrial stromal cells [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2020
Introduction: Letrozole and raloxifene are used in female reproductive disease. They have special properties and side-effects. This study was performed with aim to compare the in vitro effects of letrozole and raloxifene on human endometrial stromal ...
Maryam Pourheydar, Zahra Rashidi, Mozafar Khazaei   +2 more
doaj   +1 more source

Low dose-extended letrozole versus double dose-short letrozole protocol for ovulation induction in polycystic ovary syndrome

, 2022
Background: Letrozole, an aromatase inhibitor has been regarded as the first line drug for ovulation induction in anovulatory PCOS patients because of its monofollicular growth and there is no chance of hyperstimulation by letrozole. Traditional protocol
Nazneen, Sohely, Banu, Jesmine, Ishrat, Shakeela, Jahan, Nishat, Rani, Chalontika, Akter, Sumaiya, Jahan, Shirin, Deeba, Farzana   +7 more
core   +1 more source

Does daily co administration of gonadotropins and letrozole during the ovarian stimulation improve IVF outcome for poor and sub optimal responders?

Journal of Ovarian Research, 2020
Background Co-administration of letrozole during the first 5 days of ovarian stimulation was suggested to improve IVF outcomes in poor responders.
Moran Shapira, Raoul Orvieto, Oshrit Lebovitz, Ravit Nahum, Adva Aizer, Aliza Segev-Zahav, Jigal Haas   +6 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Misoprostol with or without letrozole pretreatment for termination of pregnancy: A randomized controlled trial

, 2011
Objective: To compare the success rate and side effects of letrozole and misoprostol versus misoprostol alone for medical termination of early pregnancy.
Ho, PC, Lee, VCY, Ng, EHY, Yeung, WSB
core   +1 more source

Effect of letrozole doses on clinical pregnancy rates in polycystic ovary syndrome: a systematic review and network meta-analysis

Gynecological Endocrinology
Letrozole, an aromatase inhibitor, is commonly used for ovulation induction in patients with polycystic ovary syndrome (PCOS). However, the effect of different doses of letrozole on pregnancy outcomes remains controversial.
Yanting Sun, Jun Wang, Guofeng Chen
doaj   +1 more source

A comparative study of ovulation induction by clomiphene citrate vs letrozole [PDF]

New Indian Journal of OBGYN
Objectives: The present study was conducted to compare ovulation induction by clomiphene citrate and letrozole in women with ovulatory dysfunction. Methodology: In this open label comparative randomized clinical trial, patients aged 20 to 40 years with
Hemant Deshpande, Madhukar Shinde, Neha Ellath, Vidya Gaikwad   +3 more
doaj   +1 more source