Results 31 to 40 of about 22,913 (185)

Effect of Letrozole on hippocampal Let-7 microRNAs and their correlation with working memory and phosphorylated Tau protein in an Alzheimer's disease-like rat model

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022
Background Let-7 microRNAs (miRNAs) may contribute to neurodegeneration, including Alzheimer's disease (AD), but, they were not investigated in Streptozotocin (STZ)-induced AD.
Nada Alaa Moustafa, Mohammed Abdelhamed El-Sayed, Somia Hassan Abdallah, Noha Mohamed Hazem, Magdy Abdelhamed Aidaros, Doaa Attia Abdelmoety   +5 more
doaj   +1 more source

Comparative study between the effect of letrozole versus letrozole with Metformin in treatment of anovulation in overweight women. [PDF]

Al-Azhar International Medical Journal, 2022
Background: Ovulation disorders account for around 30% of infertility and are frequently accompanied by irregular menstrual (oligomenorrhoea) or an absence of periods (amenorrhea).
Samir Galal, Abdallah Ahmed, Hamada Rohaim   +2 more
doaj   +1 more source

Comparison of Treatment Outcomes of Infertile Women by Clomiphene Citrate and Letrozole with Gonadotropins Underwent Intrauterine Insemination [PDF]

Acta Medica Iranica, 2012
This study was designed to compare the effect of clomiphene and letrozole in ovulatory stimulation in infertile women under intrauterine insemination who referred to Mahdiyeh infertility clinic during 2008-2009.
Shahrzad Zadehmodares, Mahnaz Niyakan, Seyede Afsar Sharafy, Maryam Hosseinnezhad Yazdi, Fatemeh Jahed   +4 more
doaj   +1 more source

Impact of 2.5 mg versus 5 mg letrozole co-treatment in an antagonist protocol for IVF: a retrospective study

Frontiers in Endocrinology, 2023
ObjectiveThe present study aimed to compare the effectiveness of two different doses of letrozole (2.5 mg and 5 mg daily) in an antagonist protocol for infertile women with normal ovarian reserve.MethodsThis retrospective cohort study included infertile ...
Jing Lin, Fenglu Wu, Kai Zhang, Yanwen Zhu, Bian Wang, Qianqian Zhu, Jiaying Lin   +6 more
doaj   +1 more source

Early Postnatal Androgenic Activity Inhibition Produces Differential Long‐Term Alterations in Anxiety‐Like Behavior in Young Adult Male and Female Wistar Rats [PDF]

Dev Psychobiol
ABSTRACT Sex differences in anxiety‐like behavior are influenced by gonadal steroids, yet the contribution of early postnatal androgen signaling and testosterone metabolic pathways to the long‐term organization of these behaviors remains unclear. Wistar male and female rats received daily s.c.
Primo U, Fernández‐García J, García‐Úbeda R, Collado P, Carrillo B, Pinos H.   +5 more
europepmc   +2 more sources

Global expression response of genes in sex-undifferentiated Nile tilapia gonads after exposure to trace letrozole

Ecotoxicology and Environmental Safety, 2021
The aromatase inhibitor letrozole can be found in rivers, effluents, and even drinking water. Studies have demonstrated that letrozole affects various metabolic pathways and may cause reproductive toxicity, especially in fish exposed during development ...
Jian Teng, Yan Zhao, Hong Ju Chen, Liang Yi Xue, Xiang Shan Ji   +4 more
doaj   +1 more source

Matching-adjusted indirect comparison of PFS and OS comparing ribociclib plus letrozole palbociclib plus letrozole as first-line treatment of HR+/HER2− advanced breast cancer

Therapeutic Advances in Medical Oncology, 2023
Background: Current standard-of-care first-line treatment of patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2−) advanced breast cancer (ABC) is cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) + endocrine
Komal Jhaveri, Joyce O’Shaughnessy, Peter A. Fasching, Sara M. Tolaney, Denise A. Yardley, Vikash Kumar Sharma, Chandroday Biswas, Astrid Thuerigen, Purnima Pathak, Hope S. Rugo   +9 more
doaj   +1 more source

A preliminary study of sex differences and histopathological observations in experimentally-induced Alzheimer’s disease albino rats with Letrozole administration [PDF]

Zagazig University Medical Journal
Background: Letrozole is an aromatase inhibitor with conflicting studies reporting its effects on memory in male and female animals, and whether the observed memory impairments become exacerbated with an additional insult such as Alzheimer's disease (AD);
Doaa Abdelmoety, Mohammed El-Sayed, Somia Abdallah, Nada Moustafa   +3 more
doaj   +1 more source

Letrozole plus misoprostol versus misoprostol alone in the induction of anembryonic missed abortion: a randomized controlled trial conducted in Upper Egypt

Middle East Fertility Society Journal, 2023
Background A missed abortion is a spontaneous abortion in which the embryo or fetus has already died but has remained in the uterus for days or weeks with a closed cervical ostium.
Ramy Heshmat Zekry Tadros, Usama Fouda, Sherif Sameh Zaki, Marwa Abdalla   +3 more
doaj   +1 more source

Anything Rare is Possible: Letrozole Induced Eczematous Skin Eruption [PDF]

Journal of Clinical and Diagnostic Research, 2014
Letrozole is used as first line drug in postmenopausal women with early-stage or advanced hormone-sensitive breast cancer. Letrozole has favourable tolerability profile when administered once daily and significant adverse reactions occur rarely.
Amruta Tripathy, Meena Kumari. K, Mohan Babu A.V., Sathish Pai B, Mahesh Kumar D.   +4 more
doaj   +1 more source