Results 141 to 150 of about 285,613 (247)

Active Learning‐Assisted Exploration of [PO40Mo12]3− for Alzheimer's Therapy Insights

Advanced Science, EarlyView.
Bayesian Optimization coupled with active learning to uncover the interaction mechanism of [PO40Mo12]3− on amyloid‐β peptide. Abstract Alzheimer's disease (AD), involving amyloid‐β (Aβ) aggregation, has potential therapeutic modulators in polyoxometalates (POMs) like [PMo12O40]3−.
Lincan Fang, Ruoxue Peng, Luping Xia, Gui‐lin Zhuang   +3 more
wiley   +1 more source

Characterization of Leucine Transfer Ribonucleic Acid in Escherichia coli following Infection with Bacteriophage T2

, 1968
James Kan, Tamiko Kano‐Sueoka, Noboru Sueoka   +2 more
openalex   +1 more source

Inhibition of protein synthesis in Krebs 2 ascites cells and cell-free systems by phenylalanine and its effect on leucine and lysine in the amino acid pool [PDF]

, 1968
Joan P. Roscoe, Monroe D. Eaton, Gladys Chin Choy   +2 more
openalex   +1 more source

Deficiency of Leucine‐Rich Repeat Containing G Protein‐Coupled Receptor 4 in Pancreas Reduces β Cell Mass

Advanced Science, EarlyView.
In islet β cells, LGR4 binds with Rspondin to activate the Wnt‐β‐catenin‐Ccnd1 axis, leading to a subsequent increase in cell proliferation. On the other hand, LGR4 also binds with RANKL, thus suppressing the phosphorylation of p44/p42 MAPK and p65 NF‐κB and subsequent cell apoptosis.
Chao Luo, Yifan Feng, Jiajie Min, Yan Zhao, Ziming Zhu, Lijun Sun, Hao Yin, Yue Yin, Weizhen Zhang   +8 more
wiley   +1 more source

Lung Delivery of Lactose-Free Microparticles Loaded with Azithromycin for the Treatment of Bacterial Infections. [PDF]

Pharmaceutics
Molina G, Serrano DR, Dea-Ayuela MA, Rodriguez C, González-Burgos E, Anaya BJ.   +5 more
europepmc   +1 more source

Back Mutation of Leucine-Requiring Auxotrophs of Salmonella typhimurium Induced by Diethylsulphate

, 1964
A. Ronen
openalex   +1 more source

BIOSYNTHESIS OF INSULIN IN BOVINE FETAL PANCREATIC SLICES: THE INCORPORATION OF TRITIATED LEUCINE INTO A SINGLE-CHAIN PROINSULIN, A DOUBLE-CHAIN INTERMEDIATE, AND INSULIN IN SUBCELLULAR FRACTIONS [PDF]

, 1969
A. K. Tung, Christopher Yip
openalex   +1 more source

MoMtg1 Acts as a Novel Transcriptional Repressor of MoSwi6 During Appressorium‐Mediated Penetration in the Rice Blast Fungus

Advanced Science, EarlyView.
Appressoria are specialized penetration structures for many plant pathogenic fungi, demanding precise cell cycle control. This study unveils MoMtg1 as a transcriptional repressor of MoSwi6, orchestrating MoCYC1 expression during turgor‐driven cell cycle progression to enable appressorium‐mediated penetration. Moreover, a small‐molecule inhibitor ZS1619
Xingyu Wang, Ting Zhang, Qi Li, Chang‐An Ji, Lin Huang, Mingzhi Zhang, Leiyun Yang, Xinyu Liu, Muxing Liu, Gang Li, Zhengguang Zhang, Haifeng Zhang   +11 more
wiley   +1 more source

Nutrition and exercise for sarcopenia treatment. [PDF]

Osteoporos Sarcopenia
Kim H, Kim J, Lee C, Kim S.
europepmc   +1 more source

Evidence for an Altered Operator Specificity: Catabolite Repression Control of the Leucine Operon in Salmonella typhimurium [PDF]

, 1968
Stephen B. Friedman, Paul Margolin
openalex   +1 more source