Results 141 to 150 of about 603,709 (398)

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Crystal structure and DFT study of bis{(S)-2-[(2-hydroxybenzyl)amino]-4-methylpentanoato-κ2N,O}(1,10-phenanthroline-κ2N,N′)nickel(II)

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the title compound, [Ni(C13H18NO3)2(C12H8N2)], the NiII cation shows a distorted octahedral coordination environment. It is formed by two N atoms from the phenanthroline ligand, as well as two N and two O atoms belonging to two 2-[(2-hydroxybenzyl ...
Md. Serajul Haque Faizi, Necmi Dege, Sergey Malinkin   +2 more
doaj   +1 more source

Leucine Aminopeptidase in Candida Albicans

Journal of Investigative Dermatology, 1962
Since the late 19th century, there have been numerous publications on proteolytic enzymes in dermatophytes (for literature see 1-5). Bodin (1907), Mallinckrodt-Haupt (1928), and Tate (1929) stated that active proteolytic enzymes (e.g. trypsin, casease, renin, gelatinase (1, 2), or enzymes with activity very similar to trypsin (3)) are present in the ...
Donald Chow, Young Pio Kim, Kenji A. Adachi   +2 more
openaire   +3 more sources

Tumor‐Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion

Advanced Science, EarlyView.
This study identifies Globo H ceramide (GHCer) as a novel immune checkpoint molecule that suppresses the activation of conventional T lymphocytes while promoting the differentiation and function of regulatory T cells. The immunosuppressive effects of GHCer are mediated through the activation of the A2AR/cAMP/PKA pathway, which involves its interactions
Jing‐Yan Cheng, Hsiu‐Hui Tsai, Jung‐Tung Hung, Tsai‐Hsien Hung, Chun‐Cheng Lin, Chien‐Wei Lee, Zi‐Chi Lo, Jing‐Rong Huang, Shih‐Pin Chiou, Yenlin Huang, Shih‐Hsiang Chen, Chun‐Nan Yeh, John Yu, Alice L. Yu   +13 more
wiley   +1 more source

Hyperglycemia Stimulates the Irreversible Catabolism of Branched-Chain Amino Acids and Generation of Ketone Bodies by Cultured Human Astrocytes

Biomedicines
Astrocytes are considered to possess a noticeable role in brain metabolism and, as a partners in neuron–glia cooperation, to contribute to the synthesis, bioconversion, and regulation of the flux of substrates for neuronal metabolism.
Eduard Gondáš, Eva Baranovičová, Jakub Šofranko, Radovan Murín   +3 more
doaj   +1 more source

Amino-acid utilization in bacterial growth. 1. Peptide utilization by a leucine-requiring mutant of Escherichia coli [PDF]

, 1953
Marie-Louise Hirsch, G. N. Cohen
openalex   +1 more source

JA‐Mediated Regulation of Amino Acid Homeostasis Adjusts Metabolic Flux and Enhances Spider Mite Tolerance via the SlJAZ8‐SlWRKY57‐SlAVT6s Module in Tomato

Advanced Science, EarlyView.
This study elucidates a novel SlJAZ8‐SlWRKY57‐SlAVT6A/SlAVT6B module that effectively channels metabolic flux from primary to secondary metabolism, impacting plant growth, development, and resistance. Two novel vacuolar amino acid exporters, SlAVT6A and SlAVT6B, fine‐tunes trichomes, terpenes, and gibberellins, bolstering spider mite resistance.
Yingchen Hao, Xiaolong Wang, Langchen Guo, Lijun Xiang, Enxi Luo, Peng Cao, Penghui Liu, Yue Zhong, Chun Li, Jun Lai, Jun Yang, Shouchuang Wang   +11 more
wiley   +1 more source

Enhancing Selective Antimicrobial and Antibiofilm Activities of Melittin through 6-Aminohexanoic Acid Substitution

Biomolecules
Leucine residues are commonly found in the hydrophobic face of antimicrobial peptides (AMPs) and are crucial for membrane permeabilization, leading to the cell death of invading pathogens.
Naveenkumar Radhakrishnan, Sukumar Dinesh Kumar, Song-Yub Shin, Sungtae Yang   +3 more
doaj   +1 more source

The non-identity of Thudichum's ‘glycoleucine’ and norleucine [PDF]

, 1945
R. Consden, A. H. Gordon, A. J. P. Martin, Otto Rosenheim, R. L. M. Synge   +4 more
openalex   +1 more source

Experimental Evidence for a Metallohydrolase Mechanism in Which the Nucleophile Is Not Delivered by a Metal Ion: EPR Spectrokinetic and Structural Studies of Aminopeptidase from \u3cem\u3eVibrio proteolyticus\u3c/em\u3e [PDF]

, 2007
Metallohydrolases catalyse some of the most important reactions in biology and are targets for numerous chemotherapeutic agents designed to combat bacterial infectivity, antibiotic resistance, HIV infectivity, tumour growth, angiogenesis and immune ...
Bennett, Brian, Kim, Jung Ja, Kittell, Aaron W., Kumar, Amit, Periyannan, Gopal R.   +4 more
core   +1 more source