Results 11 to 20 of about 355,417 (306)

The Effect of Ex Vivo Human Serum from Liver Disease Patients on Cellular Protein Synthesis and Growth

Cells, 2022
Sarcopenia is a common complication affecting liver disease patients, yet the underlying mechanisms remain unclear. We aimed to elucidate the cellular mechanisms that drive sarcopenia progression using an in vitro model of liver disease.
Sophie L. Allen, Alex P. Seabright, Jonathan I. Quinlan, Amritpal Dhaliwal, Felicity R. Williams, Nicholas H. F. Fine, David J. Hodson, Matthew J. Armstrong, Ahmed M. Elsharkaway, Carolyn A. Greig, Yu-Chiang Lai, Janet M. Lord, Gareth G. Lavery, Leigh Breen   +13 more
doaj   +1 more source

Microbiota based personalized nutrition improves hyperglycaemia and hypertension parameters and reduces inflammation: a prospective, open label, controlled, randomized, comparative, proof of concept study [PDF]

PeerJ
Background Recent studies suggest that gut microbiota composition, abundance and diversity can influence many chronic diseases such as type 2 diabetes.
Gopalakrishna Kallapura, Anthony Surya Prakash, Kumar Sankaran, Prabhath Manjappa, Prayagraj Chaudhary, Sanjay Ambhore, Debojyoti Dhar   +6 more
doaj   +2 more sources

Consumption of High-Leucine-Containing Protein Bar Following Breakfast Impacts Aminoacidemia and Subjective Appetite in Older Persons

, 2021
Background: Limited data are available examining dietary interventions for optimizing protein and leucine intake to stimulate muscle protein synthesis (MPS) in older humans.
Everson A Nunes (12591871), Stefan H.M. Gorissen (12591649), Todd Prior, Michael Kamal (12591868), Stuart M. Phillips (261257), Stefan H M Gorissen, Daniel A. Traylor (12591865), Traylor, Daniel A., Fran Gesel, Michael Kamal, Stuart M Phillips, Lim, Changhyun, Prior, Todd, Lees, Matthew J., Matthew Lees, Nunes, Everson A, Gorissen, Stefan H.M., Fran Gesel (12591877), Changhyun Lim, Changhyun Lim (8693979), Daniel A Traylor, Kamal, Michael, Phillips, Stuart M., Matthew J. Lees (12591874), Everson A Nunes, Todd Prior (7239752), Gesel, Fran   +26 more
core   +1 more source

Daily L-leucine supplementation in novice trainees during a 12-week weight training program. [PDF]

, 2011
PURPOSE: To investigate the effects of daily oral L-leucine ingestion on strength, bone mineral-free lean tissue mass (LTM) and fat mass (FM) of free living humans during a 12-wk resistance-training program. METHODS: Twenty-six initially untrained men (n
King, RF, Zanker, C, Ispoglou, T, Polman, RC   +3 more
core   +2 more sources

Rethinking Leucine Zipper : ribonuclease activity and structural dynamics of a ubiquitous oligomerization motif [PDF]

, 2011
This dissertation focuses on structural, dynamic and catalytic properties of a Leucine Zipper (LZ) motif – a family of protein oligomerization domains which belong to the structural class of coiled coil proteins.
Nikolaev, Yaroslav
core   +1 more source

A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice

eLife, 2021
Can limb regeneration be induced? Few have pursued this question, and an evolutionarily conserved strategy has yet to emerge. This study reports a strategy for inducing regenerative response in appendages, which works across three species that span the ...
Michael J Abrams, Fayth Hui Tan, Yutian Li, Ty Basinger, Martin L Heithe, Anish Sarma, Iris T Lee, Zevin J Condiotte, Misha Raffiee, John O Dabiri, David A Gold, Lea Goentoro   +11 more
doaj   +1 more source

Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry. [PDF]

, 2010
BACKGROUND: Autism spectrum disorders (ASDs) are a group of highly heritable neurodevelopmental disorders which are characteristically comprised of impairments in social interaction, communication and restricted interests/behaviours.
Klauck, Sabine M., Mulder, EJ, Monaco, Anthony P, Klauck, Sabine M, Bailey, Anthony J., Bailey Anthony J, Poustka Fritz, Sousa, I, Bailey, Anthony J, Pagnamenta Alistair T, Fritz Poustka, Mulder, Erik J., Alistair T Pagnamenta, Battaglia Agatino, Taane G Clark, Clark, Taane Gregrory, Mulder Erik J, Clark, Taane G., Monaco, AP, Pagnamenta, Alistair T, Minderaa Ruud B, Klauck Sabine M, Sousa, Inês, Pagnamenta, AT, Anthony P Monaco, Monaco Anthony P, Erik J Mulder, null null, Clark, Taane G, Clark, TG, Klauck, SM, Monaco, Anthony P., Ruud B Minderaa, Pagnamenta, Alistair T., Minderaa, Ruud B., Inês Sousa, Holt, Richard, International Molecular Genetic Study of Autism Consortium (IMGS, Monaco, Anthony, Richard Holt, Anthony J Bailey, Clark Taane G, Minderaa, Ruud B, Battaglia, Agatino, Holt, R, Sabine M Klauck, Bailey, AJ, Agatino Battaglia, Holt Richard, Minderaa, RB, Mulder, Erik J, Sousa Inês, Poustka, F, Poustka, Fritz, Battaglia, A   +54 more
core   +1 more source

Chronic leucine supplementation improves lipid metabolism in C57BL/6J mice fed with a high-fat/cholesterol diet

Food & Nutrition Research, 2016
Background: Leucine supplementation has been reported to improve lipid metabolism. However, lipid metabolism in adipose tissues and liver has not been extensively studied for leucine supplementation in mice fed with a high-fat/cholesterol diet (HFCD ...
Jun Jiao, Shu-Fen Han, Wei Zhang, Jia-Ying Xu, Xing Tong, Xue-Bin Yin, Lin-Xi Yuan, Li-Qiang Qin   +7 more
doaj   +1 more source

Divergent Metabolic Regulation of Autophagy and mTORC1—Early Events in Alzheimer’s Disease?

Frontiers in Aging Neuroscience, 2017
Alzheimer’s disease (AD) is a progressive disease associated with the production and deposition of amyloid β-peptide (Aβ) aggregates and neurofibrillary tangles, which lead to synaptic and neuronal damage.
Mai A. Shafei, Matthew Harris, Myra E. Conway   +2 more
doaj   +1 more source

Amino acid content and biomass productivity of selected weed species as an indicator of their response to herbicide stress

Acta Agrobotanica, 2013
Biomass reduction and amino acid content in plants of Papaver rhoeas L. and Stellaria media L. were investigated to evaluate response of these species to herbicide stress under various temperature (25/16 and 8/2 oC) and relative humidity (50 and 75 ...
Renata Kieloch, Jerzy Sadowski, Krzysztof Domaradzki   +2 more
doaj   +1 more source