Divergent Metabolic Regulation of Autophagy and mTORC1—Early Events in Alzheimer’s Disease?
Frontiers in Aging Neuroscience, 2017 Alzheimer’s disease (AD) is a progressive disease associated with the production and deposition of amyloid β-peptide (Aβ) aggregates and neurofibrillary tangles, which lead to synaptic and neuronal damage.
Mai A. Shafei +2 more
doaj +1 more source
Targeting the muscle for the treatment and prevention of hepatic encephalopathy [PDF]
, 2016 Muscle mass loss or sarcopenia is a principle component of malnutrition which prevails in 65–90% of patients with end-stage liver disease [1]. Intuitively, the roots of malnutrition play a precipitating role in muscle catabolism.
Bémeur, Chantal +2 more
core +2 more sources
Acta Agrobotanica, 2013 Biomass reduction and amino acid content in plants of Papaver rhoeas L. and Stellaria media L. were investigated to evaluate response of these species to herbicide stress under various temperature (25/16 and 8/2 oC) and relative humidity (50 and 75 ...
Renata Kieloch +2 more
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Frontiers in Nutrition, 2021 Recommendations concerning protein quantity, source, and leucine intake for older adults are difficult to reach by regular dietary intake. This randomized clinical trial assesses in sarcopenic community-dwelling older adults (i) the regular (non ...
Lenore Dedeyne +10 more
doaj +1 more source
Sarcopenia from mechanism to diagnosis and treatment in liver disease [PDF]
, 2016 Sarcopenia or loss of skeletal muscle mass is the major component of malnutrition and is a frequent complication in cirrhosis that adversely affects clinical outcomes.
Dasarathy, Srinivasan, MERLI, Manuela
core +1 more source
Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis
Nutrients, 2020 Lipid metabolism is an important and complex biochemical process involved in the storage of energy and maintenance of normal biological functions. Leucine, a branched amino acid, has anti-obesity effects on glucose tolerance, lipid metabolism, and ...
Lingyu Zhang +7 more
semanticscholar +1 more source
Hypoglycæmic Response to Leucine in a Leucine-sensitive Man [PDF]
Nature, 1960 IT has been reported previously1,2 that certain individuals show a profound lowering of the blood glucose-level following ingestion of leucine or iso-valeric acid and that this is a familial trait.
W J, BUTTERFIELD +3 more
openaire +2 more sources
Genes of different catabolic pathways are coordinately regulated by Dal81 in Saccharomyces cerevisiae [PDF]
, 2015 Yeast can use a wide variety of nitrogen compounds. However, the ability to synthesize enzymes and permeases for catabolism of poor nitrogen sources is limited in the presence of a rich one.
Bermudez Moretti, Mariana +2 more
core +3 more sources
Structure and mechanical properties of artificial protein hydrogels assembled through aggregation of leucine zipper peptide domains [PDF]
, 2007 Artificial protein hydrogels made from a triblock protein (designated AC10A, where A is an acidic zipper domain and C10 comprises 10 repeats of the nonapeptide sequence exhibit normalized plateau storage moduli (G/nkT) less than 0.13 at all ...
Kornfield, Julia A. +2 more
core +1 more source
Estimation of the leucine and histidine requirements for piglets fed a low-protein diet
Animal, 2016 Reduction of the CP content in the diets of piglets requires supplementation with crystalline essential amino acids (AA). Data on the leucine (Leu) and histidine (His) requirements of young pigs fed low-CP diets are limited and have primarily been ...
A.G. Wessels +5 more
doaj +1 more source