Results 21 to 30 of about 355,417 (306)

Personalized Protein Supplementation Improves Total Protein, Leucine, and Energy Intake in (Pre)Sarcopenic Community-Dwelling Older Adults in the ENHANce RCT

open access: yesFrontiers in Nutrition, 2021
Recommendations concerning protein quantity, source, and leucine intake for older adults are difficult to reach by regular dietary intake. This randomized clinical trial assesses in sarcopenic community-dwelling older adults (i) the regular (non ...
Lenore Dedeyne   +10 more
doaj   +1 more source

Mitochondrial leucine tRNA level and PTCD1 are regulated in response to leucine starvation [PDF]

open access: yes, 2014
Pentatricopeptide repeat domain protein 1 (PTCD1) is a novel human protein that was recently shown to decrease the levels of mitochondrial leucine tRNAs. The physiological role of this regulation, however, remains unclear.
Schaller, André   +6 more
core   +1 more source

Leucine-Restricted Diet Ameliorates Obesity-Linked Cognitive Deficits: Involvement of the Microbiota–Gut–Brain Axis

open access: yes, 2023
Leucine restriction (LR) improves insulin resistance and promotes white adipose tissue browning. However, the effect of LR on obesity-associated cognitive impairment remains unclear.
Boyang Wang   +19 more
core   +1 more source

Estimation of the leucine and histidine requirements for piglets fed a low-protein diet

open access: yesAnimal, 2016
Reduction of the CP content in the diets of piglets requires supplementation with crystalline essential amino acids (AA). Data on the leucine (Leu) and histidine (His) requirements of young pigs fed low-CP diets are limited and have primarily been ...
A.G. Wessels   +5 more
doaj   +1 more source

Leucine-enriched essential amino acid supplementation in mechanically ventilated trauma patients – a feasibility study [PDF]

open access: yes, 2019
Background: Critically ill patients lose up to 2% muscle mass per day. We assessed the feasibility of administering a leucine-enriched essential amino acid (L-EAA) supplement to mechanically ventilated trauma patients with the aim of assessing the effect
Frost, GS   +35 more
core   +1 more source

Response of piglets to the standardized ileal digestible isoleucine, histidine and leucine supply in cereal–soybean meal-based diets

open access: yesAnimal, 2013
Improving the amino acid (AA) profile of the diet by using l-Lys, l-Thr, dl-Met, l-Trp and l-Val helps to reduce the dietary CP content, thereby reducing nitrogen excretion while maintaining the performance of pigs.
M. Gloaguen   +4 more
doaj   +1 more source

Leucine degradation in sheep [PDF]

open access: yesBritish Journal of Nutrition, 1988
1. In vitro leucine catabolism in adipose tissue, skeletal muscle, kidney and liver homogenates was studied in sheep.2. In Expt 1, Suffolk × Targhee ram lambs were slaughtered at 1, 28, 56, 84, 112, 140, 168, 196, 224 and 365 d of age. In Expt 2, 5-month-old crossbred wethers were fed on 80, 120 or 180 g crude protein (nitrogen × 6·25) /kg diets for 4 ...
W G, Bergen, J R, Busboom, R A, Merkel
openaire   +2 more sources

Synthesis and Antiviral Bioactivity of Chiral Thioureas Containing Leucine and Phosphonate Moieties

open access: yesMolecules, 2010
A series of novel chiral thioureas 3a-n bearing leucine and phosphonate moieties were synthesized in excellent yields. The structures of the compounds were completely characterized by elemental analysis, IR, 1H-, 13C-, 31P- and 19F-NMR spectral data.
Jian Wu   +7 more
doaj   +1 more source

Inhalable, Spray-Dried Terbinafine Microparticles for Management of Pulmonary Fungal Infections: Optimization of the Excipient Composition and Selection of an Inhalation Device

open access: yesPharmaceutics, 2021
Terbinafine is a broad-spectrum antifungal agent with therapeutic potential against pulmonary aspergillosis. The main aim of the current study was to investigate the potential of l-leucine, alone and in combination with mannitol, to improve the ...
Khaled Almansour   +6 more
doaj   +1 more source

A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins [PDF]

open access: yes, 2011
Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Leonardi, Emanuela   +23 more
core   +1 more source

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