Results 231 to 240 of about 526,044 (282)

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Efficacy of leucine-rich high protein supplementation on body composition and muscle function among older adults with sarcopenia: a randomized controlled trial. [PDF]

Eur J Nutr
Chung SX, Shahar S, Ajit Singh DK, Malek Rivan NF, Abdul Karim N, Nik Fuad NF, Ong YQ, Arifin A, Abd Rahni AA.   +8 more
europepmc   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Causal relationship between branched-chain amino acids and their metabolites and frailty: A two-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Zhou Y, Di W.
europepmc   +1 more source

Incorporation of microbially salvaged urea-nitrogen into anabolic amino acids during hibernation in arctic ground squirrels. [PDF]

Commun Biol
Rice SA, Grond K, Gering SM, Reisz JA, Bailey-Parsons TRM, Buck CL, Duddleston KN.   +6 more
europepmc   +1 more source

Metabolites in Early-Mid Pregnancy Mediate the Association Between Prepregnancy Body Mass Index and Risk of Gestational Diabetes Mellitus. [PDF]

J Diabetes Res
Wang S, Zheng Y, Luo M, Chen W, Guo J, Jiang R, Yu X.   +6 more
europepmc   +1 more source

Hepatic steatosis in humans is associated with preserved glucagon action on amino acid metabolism. [PDF]

J Clin Invest
Christie HE, Mohan S, Egan AM, Boscolo F, Dalla Man C, Thompson SM, Jundt M, Fleming CJ, Andrews JC, Bailey KR, Jensen MD, Nair KS, Vella A.   +12 more
europepmc   +1 more source

Leucine-Dependent SLC7A5-PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages. [PDF]

Adv Sci (Weinh)
Zhong S, Wang X, Li Q, Wang S, Sun B, Ni W, Zhou G, Wang F, Xie X, Jin C, Xu G, Zhao P, Peng X, Han F, Xi X, Wang Y, Xu J, Wang Y, Gu X, Li S, Zhang J, Li S, Tian J.   +22 more
europepmc   +1 more source

Comparative effects of dairy, hybrid and plant-based protein blends (including fibre fortification) on amino acid profiles and gut microbiota adaptations: The Promephy study. [PDF]

Curr Res Food Sci
Roberts J, Lillis J, Mercer J, Mercer H, Kostopoulos I, Dopheide L, Willmott AGB, Tims S, Furber M, Helvoort AV, Pinto JM.   +10 more
europepmc   +1 more source