Results 41 to 50 of about 603,709 (398)

MELK-a conserved kinase: functions, signaling, cancer, and controversy. [PDF]

, 2015
Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implicated in embryogenesis and cell cycle control.
Beullens, Monique, Ganguly, Ranjit, Kornblum, Harley I, Mohyeldin, Ahmed, Nakano, Ichiro, Thiel, Jordyn   +5 more
core   +2 more sources

Branched-Chain Amino Acid Supplementation Alters the Abundance of Mechanistic Target of Rapamycin and Insulin Signaling Proteins in Subcutaneous Adipose Explants from Lactating Holstein Cows

Animals, 2021
The objective of this study was to investigate changes in protein abundance of mTOR and insulin signaling pathway components along with amino acid (AA) transporters in bovine s.c. adipose (SAT) explants in response to increased supply of Leu, Ile, or Val.
Yusheng Liang, Fabiana F. Cardoso, Claudia Parys, Felipe C. Cardoso, Juan J. Loor   +4 more
doaj   +1 more source

Sarcopenia from mechanism to diagnosis and treatment in liver disease [PDF]

, 2016
Sarcopenia or loss of skeletal muscle mass is the major component of malnutrition and is a frequent complication in cirrhosis that adversely affects clinical outcomes.
Dasarathy, Srinivasan, MERLI, Manuela
core   +1 more source

Beneficial Effects of Leucine Supplementation on Criteria for Sarcopenia: A Systematic Review

Nutrients, 2019
Objective: Treating sarcopenia remains a challenge, and nutritional interventions present promising approaches. We summarize the effects of leucine supplementation in treating older individuals with sarcopenia associated with aging or to specific ...
F. Martínez-Arnau, Rosa Fonfría-Vivas, O. Cauli   +2 more
semanticscholar   +1 more source

Serum Branched-Chain Amino Acid Metabolites Increase in Males When Aerobic Exercise Is Initiated with Low Muscle Glycogen

Metabolites, 2021
This study used global metabolomics to identify metabolic factors that might contribute to muscle anabolic resistance, which develops when aerobic exercise is initiated with low muscle glycogen using global metabolomics.
Lee M. Margolis, J Philip Karl, Marques A. Wilson, Julie L. Coleman, Claire C. Whitney, Stefan M. Pasiakos   +5 more
doaj   +1 more source

Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease [PDF]

, 2009
Maple syrup urine disease (MSUD) is an inherited disorder of branched-chain amino acid metabolism presenting with lifethreatening cerebral oedema and dysmyelination in affected individuals.
Ara  jo, Ba  os, Cremer, Crome, Daniel, Dhopeshwarkar, Dodd, G. E. Homanics, H. S. Paul, Hariharan, Hauber, Homanics, J. Lazovic, J. M. Flanagan, Jan, K. C. Cheng, K. F. LaNoue, K. Griffin, K. J. Skvorak, Kamei, Killian, Le Masurier, Lowry, Lo  , M. C. Bewley, Mackenzie, McKean, Morton, O'Callaghan, Ouary, Patel, Patel, Regunathan, Schadewaldt, Schmithorst, Schonberger, Sgaravatti, She, SILBERMAN, Simon, Tews, W. J. Zinnanti, Wajner, Williamson, Yudkoff   +44 more
core   +2 more sources

Study of amino acids absorption and gut microbiome on consumption of pea protein blended with enzymes-probiotics supplement

Frontiers in Nutrition
The current randomized, double-blind, crossover clinical trial was conducted to evaluate changes in the amino acid absorption and gut microbiota on consumption of pea protein supplemented with an enzymes-probiotics blend (Pepzyme Pro).
Abhijit Rathi, Tejal Gaonkar, Debojyoti Dhar, Gopalakrishna Kallapura, Swati Jadhav   +4 more
doaj   +1 more source

Diel rhythmicity in amino acid uptake by Prochlorococcus [PDF]

, 2008
The marine cyanobacterium Prochlorococcus, the most abundant phototrophic organism on Earth, numerically dominates the phytoplankton in nitrogen (N)-depleted oceanic gyres.
Burkill, Peter H., Garczarek, Laurence, Kolowrat, Christian, Mary, Isabelle, Scanlan, David J., Tarran, Glen A., Terry, Matthew J., Zubkov, Mikhail V.   +7 more
core   +3 more sources

Exercise and Dietary-Protein as a Countermeasure to Skeletal Muscle Weakness: Liverpool Hope University – Sarcopenia Aging Trial (LHU-SAT)

Frontiers in Physiology, 2019
ObjectiveTo investigate the effects of a 16-week concurrent exercise regimen [resistance exercise (RE) + functional exercise (FE)] in combination with, or without, a leucine-enriched whey protein isolate supplement on muscle strength, physical ...
Ben Kirk, Kate Mooney, Farzad Amirabdollahian, Omid Khaiyat   +3 more
doaj   +1 more source

Leucine in the Sky with Diamonds [PDF]

Structure, 2003
AbstractNew structures of LD motifs bound to the focal adhesion targeting domain show that the motifs are recognized as amphipathic α helices. The structures highlight the structural and functional diversity of leucine and aspartic acid-based targeting motifs.
openaire   +2 more sources