Results 51 to 60 of about 545,233 (335)

Estimation of the leucine and histidine requirements for piglets fed a low-protein diet

Animal, 2016
Reduction of the CP content in the diets of piglets requires supplementation with crystalline essential amino acids (AA). Data on the leucine (Leu) and histidine (His) requirements of young pigs fed low-CP diets are limited and have primarily been ...
A.G. Wessels, H. Kluge, N. Mielenz, E. Corrent, J. Bartelt, G.I. Stangl   +5 more
doaj   +1 more source

L-Leucine Improves Metabolic Disorders in Mice With in-utero Cigarette Smoke Exposure

Frontiers in Physiology, 2021
Objectives: Maternal cigarette smoke exposure (SE) causes intrauterine undernutrition, resulting in increased risk for metabolic disorders and type 2 diabetes in the offspring without sex differences.
Yunxin Zeng, Taida Huang, Nan Wang, Yi Xu, Chunhui Sun, Min Huang, Chun Chen, Brian G. Oliver, Brian G. Oliver, Chenju Yi, Hui Chen   +10 more
doaj   +1 more source

A study of the preparation and purification of certain amino acids. [PDF]

, 1933
Typewritten sheets in cover. Thesis (M.A.)--Boston University Bibliography: 3 p.
Lindquist, Wilbert
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study

Frontiers in Nutrition
PurposeTo investigate the association between serum amino acid changes and alopecia in patients with obesity before and after bariatric surgery, and identify risk factors for postoperative alopecia.MethodsThis prospective cohort study (ChiCTR2300074104 ...
Tingwen Wang, Tingwen Wang, Jiaqing Huang, Jiaqing Huang, Xin Sun, Hai Zhao, Jun Bao, Xuehui Chu, Xiaojie Bian, Xiaojie Bian   +9 more
doaj   +1 more source

Response of piglets to the standardized ileal digestible isoleucine, histidine and leucine supply in cereal–soybean meal-based diets

Animal, 2013
Improving the amino acid (AA) profile of the diet by using l-Lys, l-Thr, dl-Met, l-Trp and l-Val helps to reduce the dietary CP content, thereby reducing nitrogen excretion while maintaining the performance of pigs.
M. Gloaguen, N. Le Floc'h, Y. Primot, E. Corrent, J. van Milgen   +4 more
doaj   +1 more source

MCCC2 promotes HCC development by supporting leucine oncogenic function

Cancer Cell International, 2021
Background The role of methylcrotonoyl-CoA carboxylase 2 (MCCC2) in the development of tumors is well-established, and the involvement of leucine in the liver is well-known.
Yu-Yan Chen, Xue-Ning Zhang, Chen-Zhou Xu, Dan-Hua Zhou, Jing Chen, Zhao-Xiu Liu, Ying sun, Wei Huang, Li-Shuai Qu   +8 more
doaj   +1 more source

Depletion of Branched-Chain Aminotransferase 2 (BCAT2) Enzyme Impairs Myoblast 3 Survival and Myotube Formation [PDF]

, 2019
Much is known about the positive effects of branched-chain amino acids (BCAA) in regulating muscle protein metabolism. Comparatively much less is known about the effects of these amino acids and their metabolites in regulating myotube formation.
ADEGOKE, OLASUNKANMI, Dhanani, Zameer N., Mann, Gagandeep   +2 more
core  

Precursors of Cytochrome Oxidase in Cytochrome-Oxidase-Deficient Cells of Neurospora crassa [PDF]

, 1974
Three different cell types of Neurospora crassa deficient in cytochrome oxidase were studied: the nuclear mutant cni-1, the cytoplasmic mutant mi-1 and copper-depleted wild-type cells. * 1.
Ebner E., Ebner E., Edwards D. L., Kiese M., Lansman R., Mason T. L., Mason T. L., Mitchell M. B., Paul K. G., Rifkin M. R., Rubin M. S., Rubin M. S., Schwab A. J., Sebald W., Sebald W., Sebald W., Shakespeare P. G., Warburg O., Weiss H., Werner S., Wohlrab H.   +20 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source