Results 51 to 60 of about 603,709 (398)

Investigations of a compartmental model for leucine kinetics using nonlinear mixed effects models with ordinary and stochastic differential equations

, 2011
Nonlinear mixed effects models represent a powerful tool to simultaneously analyze data from several individuals. In this study a compartmental model of leucine kinetics is examined and extended with a stochastic differential equation to model non-steady
Adiels, Martin, Berglund, Martin, Jirstrand, Mats, Sunnåker, Mikael, Wennberg, Bernt   +4 more
core   +1 more source

Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins. [PDF]

, 2019
The plasma membrane is a site of conflict between host defenses and many viruses. One aspect of this conflict is the host's attempt to eliminate infected cells using innate and adaptive cell-mediated immune mechanisms that recognize features of the ...
Guatelli, John, Ramirez, Peter W, Sharma, Shilpi, Singh, Rajendra, Stoneham, Charlotte A, Vollbrecht, Thomas   +5 more
core   +1 more source

Leucine, Not Total Protein, Content of a Supplement Is the Primary Determinant of Muscle Protein Anabolic Responses in Healthy Older Women.

Journal of NutriLife, 2018
Background Older adults show a blunted muscle protein synthesis (MPS) response to postprandial hyperaminoacidemia relative to younger adults. Evidence suggests that this anabolic resistance can be overcome by consuming greater quantities of leucine ...
M. Devries, C. McGlory, D. Bolster, Alison G Kamil, Maike Rahn, L. Harkness, S. Baker, Stuart M Phillips   +7 more
semanticscholar   +1 more source

Effects of branched-chain amino acids on glucose uptake and lactose synthesis rates in bovine mammary epithelial cells and lactating mammary tissue slices

Journal of Dairy Science, 2022
: Even though supplementations of essential AA (EAA) are often related to increased lactose yields in dairy cows, underlying mechanisms connecting EAA availability to the mammary glands and lactose synthesis are poorly understood.
J.V.V. Silva, S. Ganesan, H.K.J.P. Wickramasinghe, N. Stepanchenko, C.A. Kaya, D.C. Beitz, J.A.D.R.N. Appuhamy   +6 more
doaj  

Effect of a leucine-supplemented diet on body composition changes in pregnant rats bearing Walker 256 tumor

Brazilian Journal of Medical and Biological Research, 2001
Cancer patients present high mobilization of host protein, with a decrease in lean body mass and body fat depletion occurring in parallel to neoplastic growth.
G. Ventrucci, M.A.R. Mello, M.C.C. Gomes-Marcondes   +2 more
doaj   +1 more source

Plasmids in the aphid endosymbiont Buchnera aphidicola with the smallest genomes. A puzzling evolutionary story.

, 2006
Buchnera aphidicola, the primary endosymbiont of aphids, has undergone important genomic and biochemical changes as an adaptation to intracellular life.
Gil, Rosario, Latorre, Amparo, Perez-Brocal, Vicente, Sabater-Muñoz, Beatriz, Silva, Francisco J   +4 more
core   +1 more source

Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1

Science, 2019
A tRNA synthase in metabolic control Leucyl-tRNA synthetase 1 (LARS1), which covalently couples leucine to its cognate transfer RNAs (tRNAs), appears to have broader roles in the control of leucine metabolism.
Ina Yoon, M. Nam, Hoi Kyoung Kim, H. Moon, Sungmin Kim, Jayun Jang, Ji Ae Song, Seung Jae Jeong, Sang Bum Kim, Seongmin Cho, Younha Kim, Jihye Lee, Won Suk Yang, H. Yoo, Kibum Kim, Min-Sun Kim, Aerin Yang, Kyukwang Cho, Hee-Sung Park, G. Hwang, K. Hwang, J. Han, J. H. Kim, Sunghoon Kim   +23 more
semanticscholar   +1 more source

Exogenous leucine alleviates heat stress and improves saponin synthesis in Panax notoginseng by improving antioxidant capacity and maintaining metabolic homeostasis

Frontiers in Plant Science, 2023
Panax notoginseng saponins (PNSs) are used as industrial raw materials to produce many drugs to treat cardio-cerebrovascular diseases. However, it is a heat-sensitive plant, and its large-scale artificial cultivation is impeded by high temperature stress,
Haijiao Liu, Haijiao Liu, Yingwei Su, Yingwei Su, Yunxia Fan, Yunxia Fan, Denghong Zuo, Denghong Zuo, Jie Xu, Jie Xu, Yixiang Liu, Yixiang Liu, Xinyue Mei, Xinyue Mei, Huichuan Huang, Huichuan Huang, Min Yang, Min Yang, Shusheng Zhu, Shusheng Zhu   +19 more
doaj   +1 more source

Evidence for a Role for Sestrin1 in Mediating Leucine‐Induced Activation of mTORC1 in Skeletal Muscle

American Journal of Physiology. Endocrinology and Metabolism, 2019
Previous studies established that leucine stimulates protein synthesis in skeletal muscle to the same extent as a complete mixture of amino acids, and the effect occurs through activation of the mechanistic target of rapamycin in complex 1 (mTORC1 ...
Dandan Xu, K. Shimkus, H. Lacko, Lydia Kutzler, L. Jefferson, S. Kimball   +5 more
semanticscholar   +1 more source

Enantioanalysis of Leucine in Whole Blood Samples Using Enantioselective, Stochastic Sensors

Chemosensors, 2023
Enantioanalysis of amino acids became a key factor in the metabolomics of cancer. As a screening method, it can provide information about the state of health of patients.
Raluca-Ioana Stefan-van Staden, Oana-Raluca Musat   +1 more
doaj   +1 more source