Consensus on managing delayed methotrexate elimination in high-dose therapy: insights from the Middle East [PDF]
Frontiers in OncologyIntroductionHigh-dose methotrexate (HDMTX) therapy is a cornerstone in treating pediatric and adult cancers, namely, acute lymphoblastic leukemia, non-Hodgkin lymphoma, and osteosarcoma, due to its capability to penetrate the blood–brain barrier. Despite
Mubarak Al Manasour +15 more
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Design of electrochemical aptameric biosensor for the specific and selective detection of chemotherapeutic drugs: Application for paclitaxel and leucovorin [PDF]
Scientific ReportsChemotherapy continues to be a fundamental approach in treating various cancers, with combination therapies frequently improving effectiveness while minimizing toxicity. Recently, the therapeutic potential of combining Paclitaxel and Leucovorin drugs has
Shamsa Alanazi +5 more
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Fatal multiorgan dysfunction following repeated iodinated radiocontrast injection in a patient receiving low-dose oral methotrexate -a case report- [PDF]
Korean Journal of Anesthesiology, 2022 Background Methotrexate is an antimetabolite drug that blocks dihydrofolate reductase and impairs cellular DNA synthesis. Administration of intravenous iodinated radiocontrast agents can cause life-threatening toxicity in patients receiving methotrexate.
Balaji Vaithialingam +2 more
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Non-surgical management of patients with ectopic pregnancy: A review [PDF]
Гинекология, 2023 An ectopic pregnancy is a medical emergency. Currently, surgery is the main method of therapy, and non-surgical management with methotrexate is considered an acceptable alternative.
Yulia E. Dobrokhotova +6 more
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The Korean Journal of Gastroenterology, 2023 The FOLFOX regimen (combination of leucovorin, 5-fluorouracil, and oxaliplatin) is the first-line treatment for high-risk stage 2 and 3 colorectal cancer patients.
Minna Kim +4 more
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Journal of Integrated Health Sciences, 2021 High-dose methotrexate (HDMTX) is gaining importance in the management of acute lymphoblastic leukemia (ALL). Its efficacy and toxicity depends on dose strength, route of administration, and infusion time. HDMTX toxicities can be controlled by continuous
Avinash Khadela +2 more
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Frontiers in Oncology, 2023 Methotrexate is a commonly used agent in the treatment of many malignancies and rheumatologic/inflammatory diseases. Working by inhibiting dihydrofolate reductase and thereby preventing eventual formation of tetrahydrofolate, methotrexate inhibits ...
Aditya Sharma +3 more
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Khyber Medical University Journal, 2021 OBJECTIVES: To determine role of folinic acid in improving the adaptive skills and language impairment in autism spectrum disorder (ASD) among children aged 3-14 years.
Syed Fawad Saleem Shah +5 more
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Low-dose versus Standard-Dose Leucovorin in the Treatment of Colon Cancer: Mansoura University Clinical Experience in Facing the Problem of Leucovorin Shortage [PDF]
Research in Oncology, 2019 Background: Drug shortages have become a health care problem worldwide. One of the important drugs that are affected by shortage is leucovorin. It is used with 5-fluorouracil in many protocols for gastro-intestinal tumors and its shortage would have a ...
Hend Elkalla +2 more
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Effect of leucovorin (folinic acid) on the developmental quotient of children with Down's syndrome (trisomy 21) and influence of thyroid status. [PDF]
PLoS ONE, 2010 Seven genes involved in folate metabolism are located on chromosome 21. Previous studies have shown that folate deficiency may contribute to mental retardation in Down's syndrome (DS).We investigated the effect of oral folate supplementation (daily dose ...
Henri Blehaut +8 more
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