Results 1 to 10 of about 22,979 (155)
Folate Receptor Alpha Autoantibodies in Vector-Borne Disease Populations [PDF]
DiseasesBackground: Vector-borne diseases (VBDs) caused by Borrelia spp., Bartonella spp., and Babesia spp. are associated with neuropsychiatric morbidity. Cerebral folate deficiency (CFD), primarily caused by folate receptor-α autoantibodies (FRAAs) impairing ...
Lindsey Wells +3 more
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Design of electrochemical aptameric biosensor for the specific and selective detection of chemotherapeutic drugs: Application for paclitaxel and leucovorin [PDF]
Scientific ReportsChemotherapy continues to be a fundamental approach in treating various cancers, with combination therapies frequently improving effectiveness while minimizing toxicity. Recently, the therapeutic potential of combining Paclitaxel and Leucovorin drugs has
Shamsa Alanazi +5 more
doaj +2 more sources
Consensus on managing delayed methotrexate elimination in high-dose therapy: insights from the Middle East [PDF]
Frontiers in OncologyIntroductionHigh-dose methotrexate (HDMTX) therapy is a cornerstone in treating pediatric and adult cancers, namely, acute lymphoblastic leukemia, non-Hodgkin lymphoma, and osteosarcoma, due to its capability to penetrate the blood–brain barrier. Despite
Mubarak Al Manasour +15 more
doaj +2 more sources
Frontiers in PharmacologyBackgroundL-Leucovorin (l-LV; 5-formyltetrahydrofolate, folinic acid) is a precursor for 5,10-methylenetetrahydrofolate (5,10-CH2-THF), which is important for the potentiation of the antitumor activity of 5-fluorouracil (5FU).
Yehuda G Assaraf +2 more
exaly +3 more sources
Fatal multiorgan dysfunction following repeated iodinated radiocontrast injection in a patient receiving low-dose oral methotrexate -a case report- [PDF]
Korean Journal of Anesthesiology, 2022 Background Methotrexate is an antimetabolite drug that blocks dihydrofolate reductase and impairs cellular DNA synthesis. Administration of intravenous iodinated radiocontrast agents can cause life-threatening toxicity in patients receiving methotrexate.
Balaji Vaithialingam +2 more
doaj +1 more source
Non-surgical management of patients with ectopic pregnancy: A review [PDF]
Гинекология, 2023 An ectopic pregnancy is a medical emergency. Currently, surgery is the main method of therapy, and non-surgical management with methotrexate is considered an acceptable alternative.
Yulia E. Dobrokhotova +6 more
doaj +1 more source
The Korean Journal of Gastroenterology, 2023 The FOLFOX regimen (combination of leucovorin, 5-fluorouracil, and oxaliplatin) is the first-line treatment for high-risk stage 2 and 3 colorectal cancer patients.
Minna Kim +4 more
doaj +1 more source
Journal of Integrated Health Sciences, 2021 High-dose methotrexate (HDMTX) is gaining importance in the management of acute lymphoblastic leukemia (ALL). Its efficacy and toxicity depends on dose strength, route of administration, and infusion time. HDMTX toxicities can be controlled by continuous
Avinash Khadela +2 more
doaj +1 more source
Frontiers in Oncology, 2023 Methotrexate is a commonly used agent in the treatment of many malignancies and rheumatologic/inflammatory diseases. Working by inhibiting dihydrofolate reductase and thereby preventing eventual formation of tetrahydrofolate, methotrexate inhibits ...
Aditya Sharma +3 more
doaj +1 more source
Khyber Medical University Journal, 2021 OBJECTIVES: To determine role of folinic acid in improving the adaptive skills and language impairment in autism spectrum disorder (ASD) among children aged 3-14 years.
Syed Fawad Saleem Shah +5 more
doaj +1 more source