Results 11 to 20 of about 23,013 (189)

Leucovorin

Hegde VS, Patel P.
europepmc   +2 more sources

Effect of leucovorin (folinic acid) on the developmental quotient of children with Down's syndrome (trisomy 21) and influence of thyroid status. [PDF]

PLoS ONE, 2010
Seven genes involved in folate metabolism are located on chromosome 21. Previous studies have shown that folate deficiency may contribute to mental retardation in Down's syndrome (DS).We investigated the effect of oral folate supplementation (daily dose ...
Henri Blehaut, Clotilde Mircher, Aimé Ravel, Martine Conte, Veronique de Portzamparc, Gwendael Poret, Françoise Huon de Kermadec, Marie-Odile Rethore, Franck G Sturtz   +8 more
doaj   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Low-dose versus Standard-Dose Leucovorin in the Treatment of Colon Cancer: Mansoura University Clinical Experience in Facing the Problem of Leucovorin Shortage [PDF]

Research in Oncology, 2019
Background: Drug shortages have become a health care problem worldwide. One of the important drugs that are affected by shortage is leucovorin. It is used with 5-fluorouracil in many protocols for gastro-intestinal tumors and its shortage would have a ...
Hend Elkalla, Mohamed Zahi, Osama Eldamshety   +2 more
doaj   +1 more source

Folic Acid and Leucovorin Have Potential to Prevent SARS-CoV-2-Virus Internalization by Interacting with S-Glycoprotein/Neuropilin-1 Receptor Complex

Molecules, 2023
The interaction of the SARS-CoV-2 spike (S) glycoprotein receptor-binding domain with the host-cell ACE2 receptor is a well-known step in virus infection. Neuropilin-1 (NRP-1) is another host factor involved in virus internalization.
Ranko Škrbić, Maja Travar, Miloš P. Stojiljković, Dragan M. Djuric, Relja Suručić   +4 more
doaj   +1 more source

Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy

The Saudi Journal of Gastroenterology, 2017
Background/Aims: In patients with colon cancer who undergo resection for potential cure, 40–60% have advanced locoregional disease (stage III). Those who are suitable for adjuvant treatment had a definite disease-free-survival benefit.
Maddalena Zippi, Giorgio De Toma, Giovanni Minervini, Claudio Cassieri, Roberta Pica, Diodoro Colarusso, Simon Stock, Pietro Crispino   +7 more
doaj   +1 more source

Forward Chemical Genetics in Yeast for Discovery of Chemical Probes Targeting Metabolism

Molecules, 2012
The many virtues that made the yeast Saccharomyces cerevisiae a dominant model organism for genetics and molecular biology, are now establishing its role in chemical genetics.
Marie Evangelista, Curt Scharfe, Ulrich Schlecht, Robert St.Onge   +3 more
doaj   +1 more source

A case of skin damage due to overdose methotrexate poisoning

Pifu-xingbing zhenliaoxue zazhi, 2022
We report a case of skin damage due to overdose methotrexate poisoning. A 74-year-old woman presented with erythema and desquamation of trunk and limbs accompanied with pain for 8 days.
Zhe ZHUANG, Fanghua LIU, Wencong XU, Ruitao ZOU, Jiao ZHANG, Bihui YU, Hongfang LIU, Yongfeng CHEN   +7 more
doaj   +1 more source

Cisplatin, tegafur-uracil and leucovorin plus mitomycin C: an acceptably effective and toxic regimen for patients with recurrent or metastatic nasopharyngeal carcinoma

Biomedical Journal, 2013
Background: This prospective phase II clinical trial evaluated the efficacy and toxicity of cisplatin, oral tegafur-uracil, leucovorin, and mitomycin C in patients with recurrent or metastatic nasopharyngeal carcinoma.
Chia-Hsun Hsieh, Cheng-lung Hsu, Cheng-Hsu Wang, Chaung-Chi Liaw, Jen-Shi Chen, Hsien-Kun Chang, Tsai-Shen Yang, John Wen-Chen Chang, Yung-Chang Lin, Chi-Ting Liau, Ngan-Ming Tsang, Joseph Tung-Chieh Chang, Shu-Hang Ng, Hung-Ming Wang   +13 more
doaj   +1 more source

Management of Methotrexate Toxicity [PDF]

Journal of Advanced Biomedical and Pharmaceutical Sciences, 2021
High doses of methotrexate are an important chemotherapy agent in the treatment of many childhood cancers. Treatment with HDMTX can cause unwanted side effects and induce many types of toxicity (e.g.
Usama Ali, Khaled riad, Heba Awad
doaj   +1 more source