Results 21 to 30 of about 23,013 (189)

IRINOTECAN, FLUOROURACIL AND LEUCOVORIN IN PATIENTS WITH METASTATIC COLORECTAL CANCER [PDF]

Journal of IMAB, 2008
Background: Irinotecan is a topoisomerase I inhibitor that prolongs survival as second- line therapy in patients with metastatic colorectal cancer, treated with Fluorouracil and Leucovorin only.
Deyan Davidov
doaj   +1 more source

The evaluation of red blood cell folate and methotrexate levels during protocol M in childhood acute lymphoblastic leukemia

BMC Cancer, 2020
Background After High-Dose Methotrexate (HD-MTX), folinic acid rescue therapy (Leucovorin) is administered to reduce side effects in pediatric acute lymphoblastic leukemia (ALL) patients.
N. Oosterom, M. Fiocco, R. Q. H. Kloos, I. M. van der Sluis, R. Pieters, B. D. van Zelst, D. E. C. Smith, M. M. van den Heuvel-Eibrink, R. de Jonge, S. G. Heil   +9 more
doaj   +1 more source

UFT/leucovorin and oxaliplatin alternated with UFT/leucovorin and irinotecan in metastatic colorectal cancer [PDF]

British Journal of Cancer, 2004
A total of 41 metastatic colorectal cancer (CRC) patients received tegafur/uracil (UFT)+leucovorin (LV)+oxaliplatin alternated with UFT/LV+irinotecan. The overall response rate was 58.5% (95% confidence interval, 42.2-73.3%), and the median progression-free survival was 8.8 months. There were no grade 4 toxicities; 12 patients (29%) experienced grade 3
PETRIOLI R., SABATINO M., FIASCHI A. I., MARSILI S., POZZESSERE D., MESSINESE S., CORREALE P., CIVITELLI, SERENELLA, TANZINI, GABRIELLO, TANI, FRANCESCO, DE MARTINO A., MARZOCCA, GIUSEPPE, LORENZI, MARCO, GIORGI, GIORGIO, FRANCINI, GUIDO   +14 more
openaire   +6 more sources

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Safety and Efficiency of Ambulatory High-dose Methotrexate Administration among Hematological Malignancy Patients in a Tertiary Care Center

Journal of Applied Hematology
BACKGROUND: High-dose methotrexate (HDMTX) is commonly used in solid malignancies, such as osteosarcoma, and hematological malignancies, such as acute lymphoblastic leukemia and non-Hodgkin’s lymphoma.
Maged Al-Ammari, Belal Mohammed Albtoosh, Alaa Eldein Yahia, Abdullah Alrajhi, Fouad Alnajjar, Imran Tailor, Mohammed S. Alnoamani, Nawal F. AlShehry, Mohammad Alwadi, Muhned Alhumaid, Mohammed A. Marei, Hassan Alshehri, Mubarak Salem Alghamdi, Kamal K. AlZahrani, Ibraheem Motabi   +14 more
doaj   +1 more source

Folate homeostasis of cancer cells affects sensitivity to not only antifolates but also other non-folate drugs: effect of MRP expression

Pteridines, 2013
Sensitivity to antifolates can be decreased by endogenous or exogenous folates. Leucovorin protects cancer patients against toxicity of the dihydrofolate reductase inhibitor methotrexate (MTX), while folic acid is used to protect rheumatoid arthritis ...
Peters Godefridus J., Kathmann Ietje, Lemos Clara, Hooijberg Jan Hendrik, Losekoot Nienke, Jansen Gerrit   +5 more
doaj   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin Versus Sorafenib for Hepatocellular Carcinoma Refractory to Transarterial Chemoembolization: Retrospective Subgroup Analysis of 2 Prospective Trials

Technology in Cancer Research & Treatment, 2022
Purpose: Sorafenib is recommended for patients with hepatocellular carcinoma refractory to transarterial chemoembolization but with unsatisfactory overall survival and tumor response rate.
YeXing Huang MD, LiHong Zhang MD, MinKe He MD, ZhiCheng Lai MD, XiaoYun Bu MD, DongSheng Wen MD, QiJiong Li MD, Li Xu MD, Wei Wei MD, YaoJun Zhang MD, ZhongGuo Zhou MD, MinShan Chen MD, RongPing Guo MD, Ming Shi MD, Anna Kan MD   +14 more
doaj   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

OXALIPLATIN/5-FLUOROURACIL/LEUCOVORIN IN THE TREATMENT OF PATIENTS WITH METASTATIC COLORECTAL CANCER [PDF]

Journal of IMAB, 2013
Objective: Oxaliplatin/ 5- Fluorouracil/ Leucovorin is an effective therapy for patients with metastatic colorectal cancer. The aim of this study was to explore the efficacy and safety of this chemotherapy regimen in the treatment of patient with ...
Deyan N. Davidov
doaj   +1 more source