Results 61 to 70 of about 14,935 (222)

Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation [PDF]

, 2015
Figure S1. Feasibility of cryopreservation. (A) Tricistronic IDLV encoding for hGM-CSF, hIFN-α and CMV-pp65 protein used to generate SmyleDCpp65. (B) Scheme of SmyleDCpp65 generation.
Anusara Daenthanasanmak, Arnold Ganser, Bala Sai Sundarasetty, Christof von Kalle, Constanca Figueiredo, Eliana Ruggiero, Klaus Kuehlcke, Laura Gerasch, Manfred Schmidt, Michael Rothe, Olaf Oberschmidt, Raffaele Fronza, Rainer Blasczyk, Renata Stripecke, Sonja Naundorf, Stephan Kloess, Ulrike Koehl   +16 more
core   +4 more sources

Cost‐Effectiveness Analysis of Second‐Line Lisocabtagene Maraleucel in the Treatment of Refractory or Relapsed Large B‐Cell Lymphoma

European Journal of Haematology, EarlyView.
ABSTRACT Objectives CAR‐T cell therapies such as lisocabtagene maraleucel (liso‐cel) have transformed the treatment of patients with second line primary refractory or early relapsed ≤ 12 months (R/R) large B‐cell lymphoma (LBCL). The objective of this study was to assess the cost‐effectiveness of liso‐cel compared to standard of care (SOC) to treat R/R
Catherine Thieblemont, Florian Colrat, Rahma Sellami, Marine Sivignon, Adrien Petel, Sébastien Branchoux, Gérard de Pouvourville   +6 more
wiley   +1 more source

Effect of leukapheresis on pain reduction in leukemic priapism

Asian Journal of Transfusion Science, 2022
Priapism is a rare presentation of Chronic Myeloid Leukaemia (CML). It is also considered a medical emergency as delay in treatment may lead to impotence.
Shahida Noushad, Dibyajyoti Sahoo, Abhishekh Basavarajegowda, Esha Toora, Purshotam Paudel   +4 more
doaj   +1 more source

Management of Primary Refractory Diffuse Large B‐Cell Lymphoma in Patients Unsuitable for CAR T‐Cell Therapy

European Journal of Haematology, EarlyView.
ABSTRACT Primary refractory Diffuse Large B‐Cell Lymphoma is associated with poor outcomes and limited responsiveness to conventional salvage therapies. Although CAR T‐cell therapy represents the standard of care in this setting, a substantial proportion of patients cannot receive it despite meeting disease‐related criteria. In this review, “unsuitable”
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Pretreatment of filtration leukapheresis donors with colchicine [PDF]

Blood, 1978
Although filtration leukapheresis (FL) is a relatively simple and efficient means of harvesting neutrophils (PMN) for transfusion, the PMN obtained by this procedure have both functional and morphologic abnormalities induced when the cells adhere to nylon wool filters used in FL.
D G, Wright, R S, Ungerleider, J I, Gallin, A B, Deisseroth   +3 more
openaire   +3 more sources

Dynamic changes during the treatment of pancreatic cancer [PDF]

, 2018
This manuscript follows a single patient with pancreatic adenocarcinoma for a five year period, detailing the clinical record, pathology, the dynamic evolution of molecular and cellular alterations as well as the responses to treatments with ...
et al,, Wang-Gillam, Andrea, Wolff, Robert A   +2 more
core   +1 more source

Development of Chimeric Antigen Receptor‐Modified NK Cells for the Immunotherapy of Adult T‐Cell Leukemia/Lymphoma

European Journal of Haematology, EarlyView.
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy with a poor prognosis and limited therapeutic options. ATL cells exhibit aberrant surface glycosylation patterns resulting from dysregulated glycosyltransferase expression, representing a potentially tumor‐specific therapeutic target.
Yuichiro Uchida, Seigo Tateo, Masahiro Wakao, Hiroyuki Shinchi, Hayate Sawayama, Akira Fukumoto, Makoto Yoshimitsu, Yasuo Suda   +7 more
wiley   +1 more source

Absolute numbers of peripheral blood CD34+ hematopoietic stem cells prior to a leukapheresis procedure as a parameter predicting the efficiency of stem cell collection [PDF]

Терапевтический архив, 2017
Aim. To identify a parameter predicting a collection of at least 2·106 CD34+ hematopoietic stem cells (HSC)/kg body weight per leukapheresis (LA) procedure. Subjects and methods. The investigation included 189 patients with hematological malignancies and
I V Galtseva, Yu O Davydova, T V Gaponova, N M Kapranov, L A Kuzmina, V V Troitskaya, E O Gribanova, S K Kravchenko, Ya K Mangasarova, E E Zvonkov, E N Parovichnikova, L P Mendeleeva, V G Savchenko   +12 more
doaj   +1 more source

Comparison of Neutrophil Function in Granulocyte Concentrates From Prednisone- and G-CSF-Treated Donors: Effect of Stimulant, Leukapheresis and Storage

Frontiers in Medicine, 2022
Transfusion of granulocyte concentrates (GC) is an alternative therapy for neutropenic patients with life-threatening infections. While neutrophils are the main source of antimicrobial activity, only neutrophil numbers are used to certify GCs.
Andréa Murru, Andréa Murru, Andréa Murru, Marie-Ève Allard, Guillaume Paré, Guillaume Paré, Myriam Vaillancourt, Myriam Vaillancourt, Lucie Boyer, Marie-Pierre Cayer, Julien Vitry, Julien Vitry, Patricia Landry, Marie-Michèle Labrecque, Marie-Michèle Labrecque, Nancy Robitaille, Donald R. Branch, Mélissa Girard, Maria J. Fernandes, Maria J. Fernandes   +19 more
doaj   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source