Results 21 to 30 of about 2,119 (113)
Antibody–drug conjugates in cancer therapy: mechanisms and clinical studies
MedComm, Volume 5, Issue 8, August 2024.The antibodies of ADCs bind to antigens on the cell surface, forming ADC–antigen complexes. These complexes are subsequently internalized into lysosomes via receptor‐mediated endocytosis. Once inside the lysosomes, the ADCs can be degraded by enzymes or the acidic environment, releasing cytotoxic payloads that can disrupt DNA or inhibit microtubule ...
Jun He +4 more
wiley +1 more source
Sialic acid in the regulation of blood cell production, differentiation and turnover
Immunology, Volume 172, Issue 4, Page 517-532, August 2024.Sialylation is a post‐translational glycosylation modification utilized in haematopoiesis to meet the dynamic needs of the organism by enforcing rapid changes in availability of lineage‐specific cell types. Though long thought to be generated only cell‐autonomously within the intracellular ER‐Golgi secretory apparatus, emerging data also demonstrate ...
Eric Edward Irons +2 more
wiley +1 more source
Food Frontiers, Volume 5, Issue 4, Page 1749-1764, July 2024.A combination of transcriptomic and proteomic analysis was used to investigate the effect of a particular sRNA known as Salmonella adhesive‐associated sRNA (SaaS) on the intestinal damage induced by Salmonella. SaaS was found to strengthen Salmonella's invasion in the colon by specifically targeting PGLYRP1, TfR1, and HSD11B2 to suppress the host's ...
Lin‐lin Cai +5 more
wiley +1 more source
A rare type of acute leukemia in peripheral blood smear
Hematology, Transfusion and Cell Therapy, 2023 Edwin Uriel Suárez +2 more
doaj +1 more source
Treatment of refractory/relapsed Diamond–Blackfan anaemia with eltrombopag
British Journal of Haematology, Volume 204, Issue 5, Page 2077-2085, May 2024.Ribosomal defects in Diamond–Blackfan anaemia lead to slowed globin chain production, resulting in a relative overabundance of reactive iron/haem and erythroid‐specific toxicity. Based on a robust durable response of a DBA patient in another trial, we hypothesized that the thrombopoietin receptor agonist eltrombopag, which is a potent intracellular ...
Brynn B. Duncan +10 more
wiley +1 more source
BJUI Compass, Volume 5, Issue 4, Page 405-425, April 2024.Abstract Background Racial disparities in oncological outcomes resulting from differences in social determinants of health (SDOH) and tumour biology are well described in prostate cancer (PCa) but similar inequities exist in bladder (BCa) and renal cancers (RCCs).
Kunal K. Sindhu +9 more
wiley +1 more source
An arms‐race against resistance: leukemic stem cells and lineage plasticity
Molecular Oncology, Volume 18, Issue 3, Page 475-478, March 2024.AML therapy is undergoing a rapid evolution but therapy resistance hampers the hope for a true cure. Recent works have highlighted diverse lineage trajectories in AML at diagnosis and their plasticity upon relapse. Drugs often only target one lineage state providing an escape mechanism which needs to be counteracted in a personalized fashion using ...
Alexander Waclawiczek +3 more
wiley +1 more source
Plenary Abstracts Session & Oral Presentations
HemaSphere, Volume 9, Issue S1, June 2025.
wiley +1 more source
Acute Erythroblastic Leukemia Terminating a Very Long-Lasting (27 Years) Hodgkin’s Disease [PDF]
Acta Haematologica, 1982 Mantovani G +4 more
openaire +3 more sources