Results 31 to 40 of about 2,544 (194)

Role of Glucose-6-Phosphate in Metabolic Adaptation of Staphylococcus aureus in Diabetes

Microbiology Spectrum, 2021
Diabetic foot ulcer (DFU) is the most common and costly sequela of diabetes mellitus, often leading to lower-extremity amputation with poor 5-year survival rates.
Keun Seok Seo, Nogi Park, Jaime K. Rutter, Youngkyung Park, Carol L. Baker, Justin A. Thornton, Joo Youn Park   +6 more
doaj   +1 more source

Mode of Action of Staphylococcal Leukocidin: Relationship between Binding of ¹²⁵ I-Labeled S and F Components of Leukocidin to Rabbit Polymorphonuclear Leukocytes and Leukocidin Activity [PDF]

Infection and Immunity, 1981
The binding of 125 I-labeled S component to rabbit polymorphonuclear leukocytes was found to be concentration dependent and saturable at 37°C. Scatchard analysis of the binding curve gave a straight line, indicating that S component binds to a single population of sites. The dissociation constant,
M, Noda, I, Kato, F, Matsuda, T, Hirayama   +3 more
openaire   +2 more sources

Neumonía necrosante por Staphylococcus aureus extrahospitalario resistente a la meticilina:reporte de dos casos en Colombia

Biomédica: revista del Instituto Nacional de Salud, 2009
En los últimos años se ha informado la aparición de Staphylococcus aureus resistente a la meticilina como causa de infecciones extrahospitalarias graves. En Colombia, en el 2006, se publicó el primer reporte de S. aureus como causa de infección de piel y
Ana María Perilla, Camilo González, Sandra Liliana Valderrama, Natasha Vanegas, Bibiana Chavarro, Luis Carlos Triana, José Roberto Támara, Carlos Arturo Álvarez   +7 more
doaj   +1 more source

Disarming Staphylococcus aureus from destroying human cells by simultaneously neutralizing six cytotoxins with two human monoclonal antibodies

Virulence, 2018
Pathogenesis of Staphylococcus aureus is increasingly recognized to be driven by powerful toxins. Staphylococcus aureus employs up to six pore-forming toxins to subvert the human host defense and to promote bacterial invasion: alpha-hemolysin that ...
Harald Rouha, Susanne Weber, Philipp Janesch, Barbara Maierhofer, Karin Gross, Ivana Dolezilkova, Irina Mirkina, Zehra C. Visram, Stefan Malafa, Lukas Stulik, Adriana Badarau, Eszter Nagy   +11 more
doaj   +1 more source

Human Memory B Cells Targeting Staphylococcus aureus Exotoxins Are Prevalent with Skin and Soft Tissue Infection

mBio, 2018
Staphylococcus aureus is a Gram-positive opportunistic pathogen that causes superficial and invasive infections in the hospital and community. High mortality from infection emphasizes the need for improved methods for prevention and treatment. Although S.
Adam J. Pelzek, Bo Shopsin, Emily E. Radke, Kayan Tam, Beatrix M. Ueberheide, David Fenyö, Stuart M. Brown, Qianhao Li, Ada Rubin, Yi Fulmer, William K. Chiang, David N. Hernandez, Hanane El Bannoudi, William E. Sause, Alexis Sommerfield, Isaac P. Thomsen, Andy O. Miller, Victor J. Torres, Gregg J. Silverman   +18 more
doaj   +1 more source

Comparison of ferment sugars, produce hemolysis and measuring growth in methicillin-resistant and methicillin-sensitive Staphylococcus aureus isolates from inpatients and healthcare workers in Gorgan Hospitals, North of Iran [PDF]

, 2013
The mec A gene in Staphylococcus aureus leads to production of new penicillin-binding protein called PBP2a.This change may follow some changes in other phenotypes.
Amini, A., AsgharAyatollahi, A., Ghaemi, E.A., Kazemi, R., Koohsar, F., Kouhsari, E., Rahimi, S., Roustaei, M.   +7 more
core   +1 more source

Atypical Presentation of Methicillin-Susceptible Staphylococcus aureus Infection in a Dengue-Positive Patient: A Case Report with Virulence Genes Analysis

Pathogens, 2020
Concurrent bacteraemia in patients with dengue fever is rarely reported. We report a case of a patient who initially presented with symptoms typical of dengue fever but later succumbed to septic shock caused by hypervirulent methicillin-susceptible ...
Soo Tein Ngoi, Yee Wan Lee, Wen Kiong Niek, Foong Kee Kan, Sazaly AbuBakar, Sasheela Sri La Sri Ponnampalavanar, Nuryana Idris, Cindy Shuan Ju Teh   +7 more
doaj   +1 more source

Panton-Valentine Leukocidin–producing Staphylococcus aureus

Emerging Infectious Diseases, 2006
To the Editor: Panton-Valentine leukocidin (PVL) is a cytotoxin produced by Staphylococcus aureus that causes leukocyte destruction and tissue necrosis (1). Although produced by
Amos Adler, Violeta Temper, Colin S. Block, Nitsa Abramson, Allon E. Moses   +4 more
openaire   +3 more sources

Combining in vitro protein detection and in vivo antibody detection identifies potential vaccine targets against Staphylococcus aureus during osteomyelitis [PDF]

, 2016
Currently, little is known about the in vivo human immune response against Staphylococcus aureus during a biofilm-associated infection, such as osteomyelitis, and how this relates to protein production in biofilms in vitro.
Hendrickx, A.P.A. (Antoni), Reijer, P.M. (Martijn) den, Sandker, M. (Marjan), Snijders, S.V. (Susan), Tavakol, M. (Mehri), Wamel, W.J.B. (Willem) van   +5 more
core   +2 more sources

CASSETTE—clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation: study protocol for a randomised controlled trial

Trials, 2019
Background Exotoxins are important virulence factors in Staphylococcus aureus. Clindamycin, a protein synthesis inhibitor antibiotic, is thought to limit exotoxin production and improve outcomes in severe S. aureus infections.
Ravindra Dotel, Steven Y. C. Tong, Asha Bowen, Jane N. Nelson, Matthew V. N. O’Sullivan, Anita J. Campbell, Brendan J. McMullan, Philip N. Britton, Joshua R. Francis, Damon P. Eisen, Owen Robinson, Laurens Manning, Joshua S. Davis   +12 more
doaj   +1 more source