Results 31 to 40 of about 33,574 (255)

Neutrophil Elastase Increases Vascular Permeability and Leukocyte Transmigration in Cultured Endothelial Cells and Obese Mice

Cells, 2022
Neutrophil elastase (NE) plays a pivotal role in inflammation. However, the mechanism underlying NE-mediated inflammation in obesity remains unclear. Here, we report that NE activates protease-activated receptor-2 (PAR2), stimulates actin filament (F ...
Chinchu Jagadan Ushakumari, Qiong L. Zhou, Yu-Hua Wang, Sijia Na, Michael C. Rigor, Cindy Y. Zhou, Max K. Kroll, Benjamin D. Lin, Zhen Y. Jiang   +8 more
doaj   +1 more source

Human eosinophils lack human leukocyte elastase

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1996
Recently, human leukocyte elastase has been detected in human eosinophils. Reinvestigating these findings, 2.5 pg active human leukocyte elastase (E.C. 3.4.21.37) were found per neutrophil isolated from peripheral blood, whereas the elastase activity of eosinophil preparations was linearly correlated with the content of contaminating neutrophils.
Wiedow, Oliver, Muhle, Kirstin, Streit, Volker, Kameyoshi, Yoshimura   +3 more
openaire   +2 more sources

Characterization, cloning and immunogenicity of antigens released by transforming cercariae of Schistosoma mansoni [PDF]

, 2000
A schistosome infection is initiated when the parasite penetrates the skin of a susceptible host. Relatively large quantities of protein are released by transforming cercariae compared to later larval stages.
Coulson, P.S., Harrop, R., Jennings, N., Moutford, A.P., Wilson, R.A.   +4 more
core   +1 more source

Neutrophil elastase and neurovascular injury following focal stroke and reperfusion

Neurobiology of Disease, 2009
Neutrophil elastase (NE) degrades basal lamina and extracellular matrix molecules, and recruits leukocytes during inflammation; however, a basic understanding of the role of NE in stroke pathology is lacking.
Ann M. Stowe, Tracy L. Adair-Kirk, Ernesto R. Gonzales, Ronald S. Perez, Aarti R. Shah, Tae S. Park, Jeffrey M. Gidday   +6 more
doaj   +1 more source

Functional and metabolic differences between elastase-generated fragments of human lipoprotein[a] and apolipoprotein[a]

Journal of Lipid Research, 1996
We have previously shown that a functional free apolipoprotein[a] (apo[a]) can be isolated from its parent lipoprotein[a] (Lp[a]) by a mild reductive procedure.
C Edelstein, J A Italia, O Klezovitch, A M Scanu   +3 more
doaj   +1 more source

Myeloperoxidase/paraoxonase ratio as a prognostic marker for post-COVID syndrome in patients undergoing hemodialysis: A cross-sectional cohort study

Український Журнал Нефрології та Діалізу, 2023
The present study aimed to assess the impact of post-COVID syndrome on the oxidative status and activity of paraoxonase 1 (PON-1), myeloperoxidase (MPO), and leukocyte elastase in the blood of patients undergoing hemodialysis (HD). Methods.
L. Korol, N. Stepanova, O. Popova, N. Malashevska, V. Vasylchenko, T. Ostapenko, A. Rysyev, M. Kolesnyk   +7 more
doaj   +1 more source

Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo. [PDF]

, 2009
Myrtucommulone a nonprenylated acylphloroglucinol contained in the leaves of myrtle (Myrtus communis), has been reported to suppress the biosynthesis of eicosanoids by inhibition of 5-lipoxygenase and cyclooxygenase-1 in vitro and to inhibit the release ...
BRAMANTI P., CAMINITI R., CUZZOCREA S., DI PAOLA R., GENOVESE T., KOEBERLE A., MAZZON E., PERGOLA C., ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, WERZ O.   +10 more
core   +1 more source

Microenvironment Modulation‐Based Nanomaterial‐Loaded Hydrogel Dressings for Diabetic Foot Ulcers: Research Progress and Future Perspectives

Advanced Materials Interfaces, EarlyView.
xx xx. ABSTRACT Diabetic foot ulcer (DFU) is a chronic complication of diabetes, primarily caused by hyperglycemia, peripheral vascular disease, and neuropathy. Characterized by persistent hyperglycemia, impaired perfusion, inflammation, and infection, DFUs pose significant challenges to healing and are associated with high morbidity and amputation ...
Tang Yuqing, Chen Hong, Fan Weijing, Huang Renyan, You Yang, Liu Guobin   +5 more
wiley   +1 more source

Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice. [PDF]

PLoS ONE, 2016
Obesity-associated diseases such as Type 2 diabetes, liver disease and cardiovascular diseases are profoundly mediated by low-grade chronic inflammation of the adipose tissue. Recently, the importance of neutrophils and neutrophil-derived myeloperoxidase
Quinte Braster, Carlos Silvestre Roig, Helene Hartwig, Linda Beckers, Myrthe den Toom, Yvonne Döring, Mat J Daemen, Esther Lutgens, Oliver Soehnlein   +8 more
doaj   +1 more source

Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice

Frontiers in Endocrinology, 2021
A growing body of evidence indicates that neutrophils are the first major leukocyte population accumulating inside the pancreas even before the onset of a lymphocytic-driven impairment of functional beta cells in type 1 diabetes mellitus (T1D). In humans,
Yesica Garciafigueroa, Brett E. Phillips, Carl Engman, Massimo Trucco, Massimo Trucco, Nick Giannoukakis, Nick Giannoukakis   +6 more
doaj   +1 more source