Results 31 to 40 of about 32,709 (296)

Development of Immature CD4+CD8+T Cells Into Mature CD4+ T Cells Requires Alpha-1 Antitrypsin as Observed by Treatment in HIV-1 Infected and Uninfected Controls

Frontiers in Cell and Developmental Biology, 2019
Immune cells are, by default, migratory cells that traverse tissue for the purpose of carrying out recognition and recruitment in pathologic inflammation and infection.
Cynthia L. Bristow, Cynthia L. Bristow, Sara Ferrando-Martinez, Sara Ferrando-Martinez, Ezequiel Ruiz-Mateos, Manuel Leal, Ronald Winston, Ronald Winston   +7 more
doaj   +1 more source

Temporal and Quantitative Analysis of Aortic Immunopathologies in Elastase-Induced Mouse Abdominal Aortic Aneurysms

Journal of Immunology Research, 2021
Objective. Elastase-induced abdominal aortic aneurysm (AAA) model is widely used for aneurysmal pathogenesis and translational research. However, temporal alternations in aneurysmal histologies remain unknown.
Kangli Tian, Congcong Xia, Haole Liu, Boyu Xu, Panpan Wei, Weilai Fu, Ming Lu, Yankui Li, Yafeng Li, Daxin Cheng, Enqi Liu, Sihai Zhao   +11 more
doaj   +1 more source

Inflammatory Disturbances in Preeclampsia: Relationship between Maternal and Umbilical Cord Blood

Journal of Pregnancy, 2012
Preeclampsia (PE) is one of the main causes of maternal and fetal mortality and morbidity. PE is associated with an inflammatory state and with oxidative stress, in maternal circulation.
Cristina Catarino, Alice Santos-Silva, Luís Belo, Petronila Rocha-Pereira, Susana Rocha, Belmiro Patrício, Alexandre Quintanilha, Irene Rebelo   +7 more
doaj   +1 more source

Neutrophil elastase ameliorates matrix metalloproteinase-9 to promote lipopolysaccharide-induced acute lung injury in mice 1 [PDF]

Acta Cirúrgica Brasileira, 2016
PURPOSE: To investigate the regulatory roles of neutrophil elastase (NE) and matrix metalloproteinase-9 (MMP-9) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice.
Yingfei Guo, Lingyun Ma, Fei Zhang, Rongju Sun, Tanshi Li   +4 more
doaj   +1 more source

Neutrophil Elastase Increases Vascular Permeability and Leukocyte Transmigration in Cultured Endothelial Cells and Obese Mice

Cells, 2022
Neutrophil elastase (NE) plays a pivotal role in inflammation. However, the mechanism underlying NE-mediated inflammation in obesity remains unclear. Here, we report that NE activates protease-activated receptor-2 (PAR2), stimulates actin filament (F ...
Chinchu Jagadan Ushakumari, Qiong L. Zhou, Yu-Hua Wang, Sijia Na, Michael C. Rigor, Cindy Y. Zhou, Max K. Kroll, Benjamin D. Lin, Zhen Y. Jiang   +8 more
doaj   +1 more source

Human eosinophils lack human leukocyte elastase

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1996
Recently, human leukocyte elastase has been detected in human eosinophils. Reinvestigating these findings, 2.5 pg active human leukocyte elastase (E.C. 3.4.21.37) were found per neutrophil isolated from peripheral blood, whereas the elastase activity of eosinophil preparations was linearly correlated with the content of contaminating neutrophils.
Wiedow, Oliver, Muhle, Kirstin, Streit, Volker, Kameyoshi, Yoshimura   +3 more
openaire   +2 more sources

Neutrophil elastase and neurovascular injury following focal stroke and reperfusion

Neurobiology of Disease, 2009
Neutrophil elastase (NE) degrades basal lamina and extracellular matrix molecules, and recruits leukocytes during inflammation; however, a basic understanding of the role of NE in stroke pathology is lacking.
Ann M. Stowe, Tracy L. Adair-Kirk, Ernesto R. Gonzales, Ronald S. Perez, Aarti R. Shah, Tae S. Park, Jeffrey M. Gidday   +6 more
doaj   +1 more source

Functional and metabolic differences between elastase-generated fragments of human lipoprotein[a] and apolipoprotein[a]

Journal of Lipid Research, 1996
We have previously shown that a functional free apolipoprotein[a] (apo[a]) can be isolated from its parent lipoprotein[a] (Lp[a]) by a mild reductive procedure.
C Edelstein, J A Italia, O Klezovitch, A M Scanu   +3 more
doaj   +1 more source

Myeloperoxidase/paraoxonase ratio as a prognostic marker for post-COVID syndrome in patients undergoing hemodialysis: A cross-sectional cohort study

Український Журнал Нефрології та Діалізу, 2023
The present study aimed to assess the impact of post-COVID syndrome on the oxidative status and activity of paraoxonase 1 (PON-1), myeloperoxidase (MPO), and leukocyte elastase in the blood of patients undergoing hemodialysis (HD). Methods.
L. Korol, N. Stepanova, O. Popova, N. Malashevska, V. Vasylchenko, T. Ostapenko, A. Rysyev, M. Kolesnyk   +7 more
doaj   +1 more source

TGFβ (transforming growth factor-β) blockade induces a human-like disease in a nondissecting mouse model of abdominal aortic aneurysm [PDF]

, 2017
Objective-Current experimental models of abdominal aortic aneurysm (AAA) do not accurately reproduce the major features of human AAA. We hypothesized that blockade of TGF beta (transforming growth factor-beta) activity-a guardian of vascular integrity ...
Clément, Marc, Esposito, Bruno, Finigan, Alison, Lareyre, Fabien, Mallat, Ziad, Master, Leanne, Patel, Meghana, Pohlod, Stefanie, Raffort, Juliette, Stergiopulos, Nikolaos, Taleb, Soraya, Trachet, Bram, Vandestienne, Marie   +12 more
core   +2 more sources