Results 61 to 70 of about 33,574 (255)

TRPV4-A Missing Link Between Mechanosensation and Immunity [PDF]

, 2020
Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel seems to be conserved throughout all mammalian species. Of late, emerging
Kuebler, Wolfgang M., Michalick, Laura
core   +1 more source

Reactive Oxygen Species–Induced Modifications of Fibrin Clots as a Link Between Immune Responses and Atherothrombosis in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Cardiovascular events are major determinants of morbidity and mortality in systemic lupus erythematosus (SLE), particularly in patients with renal involvement. Although oxidative stress has been implicated in driving vascular and renal damage in SLE, the specific mechanisms remain unclear.
Matteo Becatti, Giacomo Emmi, Alessandra Bettiol, Amanda Mannucci, Flavia Rita Argento, Eleonora Fini, Serena Borghi, Francesca Nencini, Maria Nicastro, Irene Mattioli, Elena Silvestri, Augusto Vaglio, Domenico Prisco, Claudia Fiorillo   +13 more
wiley   +1 more source

Earthworm coelomocyte extracellular traps : structural and functional similarities with neutrophil NETs [PDF]

, 2018
ROD UJ /
Joanna Homa
core   +2 more sources

Long‐term impact of Elexacaftor/Tezacaftor/ivacaftor on pulmonary, nutritional and metabolic outcomes in homozygous F508del cystic fibrosis patients: A real‐world cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aim Elexacaftor/tezacaftor/ivacaftor (ETI) has markedly improved cystic fibrosis (CF) outcomes. However, its long‐term impact on nutrition, metabolism and liver health remains underexplored. We assessed 30‐month changes in pulmonary, nutritional, metabolic and inflammatory markers in people with CF (PwCF) homozygous for F508del.
Nicola Perrotta, Luigi Angelo Fiorito, Roberta Vescovo, Anna Virgilio, Giulia Amato, Giuseppe Cimino   +5 more
wiley   +1 more source

Platelets modulate multiple markers of neutrophil function in response to in vitro Toll-like receptor stimulation.

PLoS ONE, 2019
INTRODUCTION:In addition to their role in facilitating leukocyte-mediated inflammation, platelets can dampen leukocyte pro-inflammatory responses in some contexts.
Kathryn E Hally, Georgina K Bird, Anne C La Flamme, Scott A Harding, Peter D Larsen   +4 more
doaj   +1 more source

2-Amino- and 2-Alkylthio-4H-3,1-benzothiazin-4-ones: Synthesis, Interconversion and Enzyme Inhibitory Activities

Molecules, 2009
The synthetic access to 2-sec-amino-4H-3,1-benzothiazin-4-ones 2 was explored. Compounds 2 were available from methyl 2-thioureidobenzoates 1, 2-thioureidobenzoic acids 3, and novel 2-thioureidobenzamides 6, respectively, under different conditions.
Hans-Georg Häcker, Florian Grundmann, Friederike Lohr, Philipp A. Ottersbach, Jing Zhou, Gregor Schnakenburg, Michael Gütschow   +6 more
doaj   +1 more source

Complement, leukocytes, and leukocyte elastase in full-term neonates undergoing cardiac operation [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 1994
In 13 neonates undergoing cardiac operations for congenital cardiac defects, complement, leukocytes, and leukocyte elastase were studied during and after cardiopulmonary bypass. All but two neonates received prostaglandin E1 before the operation. The C3d/C3 ratio rose significantly during cardiopulmonary bypass from 0.86 +/- 0.55 to 1.40 +/- 0.56 (mean
M C, Seghaye, J, Duchateau, R G, Grabitz, G, Nitsch, C, Marcus, B J, Messmer, G, von Bernuth   +6 more
openaire   +2 more sources

Investigating the Ligand‐Binding Properties of N‐arylbenzimidazoles as Novel Elastase Inhibitors

ChemMedChem, EarlyView.
A series of novel N‐[(3,5‐dimethylphenyl)methyl]‐1H‐benzimidazole derivatives is designed, synthesized, and evaluated for inhibitory activity against elastase. Several compounds demonstrate an antielastase activity, including the N‐(2‐bromophenyl)‐2‐(6‐chloro‐1‐(3,5‐dimethylbenzyl)‐1H‐benzo[d]imidazol‐2‐ylthio)acetamide, showing the greatest potency ...
Giovanna Pitasi, Sonia Floris, Francesca Mancuso, Giulia Savoca, Rosaria Gitto, Antonella Fais, Laura De Luca   +6 more
wiley   +1 more source

Severity of thermal burn injury is associated with systemic neutrophil activation

Scientific Reports, 2022
Burn injuries elicit a unique and dynamic stress response which can lead to burn injury progression. Though neutrophils represent crucial players in the burn-induced immunological events, the dynamic secretion pattern and systemic levels of neutrophil ...
Maria Laggner, Marie-Therese Lingitz, Dragan Copic, Martin Direder, Katharina Klas, Daniel Bormann, Alfred Gugerell, Bernhard Moser, Christine Radtke, Stefan Hacker, Michael Mildner, Hendrik Jan Ankersmit, Thomas Haider   +12 more
doaj   +1 more source

Liver stiffness in patients with Shwachman‐Diamond syndrome

JPGN Reports, EarlyView.
Abstract Objective This case series aims to describe whether transient elastography (TE) as a marker of liver stiffness is associated with clinically important liver disease in children and young adults with Shwachman‐Diamond Syndrome (SDS). Methods All patients ≤25 years of age with genetically confirmed SDS seen in the Pediatric Gastroenterology ...
Sabina Sabharwal, Amit Grover, Paul Mitchell, Jessica Serino‐Cipoletta, Akiko Shimamura, Rima Fawaz   +5 more
wiley   +1 more source