Results 11 to 20 of about 21,234 (200)

Innovative therapeutic concepts of progressive multifocal leukoencephalopathy

Journal of Neurology, 2022
Progressive multifocal leukoencephalopathy (PML) is an opportunistic viral disease of the brain—caused by human polyomavirus 2. It affects patients whose immune system is compromised by a corresponding underlying disease or by drugs.
Nora Möhn, Lea Grote-Levi, F. Hopfner, B. Eiz-Vesper, B. Maecker-Kolhoff, C. Warnke, K. Sühs, M. Wattjes, Günter Höglinger, T. Skripuletz   +9 more
semanticscholar   +1 more source

Advances in Treatment of Progressive Multifocal Leukoencephalopathy

Annals of Neurology, 2021
Progressive multifocal encephalopathy (PML) is a severe demyelinating disease of the central nervous system (CNS) caused by JC virus (JCV), which occurs in immunocompromised individuals. Management of PML relies on restoration of immunity within the CNS.
R. Bernard-Valnet, I. Koralnik, R. D. Du Pasquier   +2 more
semanticscholar   +1 more source

Progressive multifocal leukoencephalopathy in a patient with novel mutation in the RAC2 gene: a case report

Journal of Medical Case Reports, 2022
Background Progressive multifocal leukoencephalopathy is a rare demyelinating disease that is often secondary to lytic destruction of oligodendrocytes and, to a lesser extent, to astrocytes’ response to human neurotrophic John Cunningham polyomavirus ...
Sima Bahrami, Saba Arshi, Mohammad Nabavi, Mohammad Hassan Bemanian, Morteza Fallahpour, Afshin Rezaeifar, Sima Shokri   +6 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease

Nature Reviews Neurology, 2020
Progressive multifocal leukoencephalopathy (PML) is a devastating CNS infection caused by JC virus (JCV), a polyomavirus that commonly establishes persistent, asymptomatic infection in the general population. Emerging evidence that PML can be ameliorated
I. Cortese, D. Reich, A. Nath
semanticscholar   +1 more source

Exit Strategies in Natalizumab-Treated RRMS at High Risk of Progressive Multifocal Leukoencephalopathy: a Multicentre Comparison Study

Neurotherapeutics, 2021
The main aim of the study is to evaluate the efficacy and safety profile of ocrelizumab (OCR), rituximab (RTX), and cladribine (CLA), employed as natalizumab (NTZ) exit strategies in relapsing–remitting multiple sclerosis (RRMS) patients at high-risk for
A. Zanghì, A. Gallo, C. Avolio, Rocco Capuano, M. Lucchini, M. Petracca, S. Bonavita, R. Lanzillo, D. Ferraro, E. Curti, M. buccafusca, G. Callari, S. Barone, G. Pontillo, G. Abbadessa, Valeria Di Francescantonio, E. Signoriello, G. Lus, P. Sola, F. Granella, P. Valentino, M. Mirabella, F. Patti, E. D’Amico   +23 more
semanticscholar   +1 more source

Progressive Multifocal Leukoencephalopathy [PDF]

F1000Research, 2015
Progressive multifocal leukoencephalopathy (PML) is a devastating demyelinating disease with significant morbidity and mortality and no effective, targeted therapies. It is most often observed in association with abnormalities of cell-mediated immunity, in particular human immunodeficiency virus (HIV) infection, but also occurs in association with ...
Adang, Laura, Berger, Joseph
openaire   +3 more sources

A case of progressive multifocal leukoencephalopathy in a post-kidney transplant patient with improvement after discontinuation of immunosuppressive drugs and combination therapy with mefloquine and mirtazapine

Renal Replacement Therapy, 2023
Background Progressive multifocal leukoencephalopathy is a rare disease, but the prognosis is very poor, especially in the immunosuppressed state with a non-HIV background, and there is no established treatment.
Neri Sone, Hiroki Nishiwaki, Mayu Shimokawa, Keishu Kawanishi, Tsuyoshi Oshiro, Reiji Takami, Natsuki Taira, Masahito Amagasa, Shinya Omiya, Tadahide Maezumi, Yoko Nabeshima, Kazuo Nakamichi, Yoshiharu Miura, Fumihiko Koiwa   +13 more
doaj   +1 more source

MRI Shrimp Sign in Cerebellar Progressive Multifocal Leukoencephalopathy: Description and Validation of a Novel Observation

American Journal of Neuroradiology, 2021
BACKGROUND AND PURPOSE: There are no validated imaging criteria for the diagnosis of progressive multifocal leukoencephalopathy in the cerebellum. Here we introduce the MR imaging shrimp sign, a cerebellar white matter lesion identifiable in patients ...
N. Adra, A.E. Goodheart, O. Rapalino, P. Caruso, S. Mukerji, R. González, N. Venna, J. Schmahmann   +7 more
semanticscholar   +1 more source

Risk of Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis Patient Treated With Natalizumab: A Systematic Review

Cureus, 2021
Natalizumab, a monoclonal antibody acting on alpha4 integrin receptors, is frequently used to treat multiple sclerosis patients. The biggest downside is the risk of development of progressive multifocal leukoencephalopathy, an immune-related condition ...
G. Vivekanandan, Ansha P Abubacker, Revathi Myneni, Harshika Chawla, A. Iqbal, Amit S Grewal, Andrew Ndakotsu, Safeera Khan   +7 more
semanticscholar   +1 more source

AIDS-related progressive multifocal leukoencephalopathy

Revista da Sociedade Brasileira de Medicina Tropical, 2020
INTRODUCTION: Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by reactivation of JC virus (JCV).
Carolina de Oliveira Abrão, Lissa Rodrigues Machado da Silva, Luiz Carlos Silva Souza, Nathalia de Mello Bisso, Marília Dalva Turchi, Adriana Oliveira Guilarde   +5 more
doaj   +1 more source