Results 51 to 60 of about 21,234 (200)

Non‐Syndromic Tumefactive Demyelinating Lesions in the Pediatric Population: Four Case Reports and Review of the Literature

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Introduction Tumefactive demyelinating lesions (TDLs) are large lesions (> 2 cm) seen in demyelinating syndromes such as multiple sclerosis, myelin oligodendrocyte glycoprotein antibody‐associated disorder, and neuromyelitis optica spectrum disorder. They rarely occur in children and most often have a monophasic course.
Elizabeth C. Ballinger, Hannah F. Todd, Jonathan M. Yarimi, Timothy E. Lotze, Nikita M. Shukla, Kristen S. Fisher, Alexander J. Sandweiss   +6 more
wiley   +1 more source

Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report

Frontiers in Immunology, 2022
Treating patients with cancer complicated by severe opportunistic infections is particularly challenging since classical cancer treatments, such as chemotherapy, often induce profound immune suppression and, as a result, may favor infection progression ...
Nicolas Lambert, Nicolas Lambert, Majdouline El Moussaoui, Caroline Ritacco, Martin Moïse, Martin Moïse, Astrid Paulus, Philippe Delvenne, Frédéric Baron, Frédéric Baron, Bernard Sadzot, Pierre Maquet   +11 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy (PML)

Rinsho Shinkeigaku, 2011
Progressive multifocal leukoencephalopathy (PML) is caused by reactivation of latently infected JCV when hosts' immune system is impaired by HIV infection, hematologic diseases, collagen diseases, immunemodulatory therapy and so on. PML was rare but HIV infection and Natalizumab have made it much more common while the prognosis is much better than ...
Hidehiro, Mizusawa, Shuji, Kishida, Masayuki, Saijo, Motohiro, Yukishita, Yukiko, Shishido-Hara, Hirohumi, Sawa, Kazuo, Nagashima, Souichi, Nukuzuma, Masahito, Yamada   +8 more
openaire   +3 more sources

Progressive multifocal leukoencephalopathy after fingolimod treatment

Neurology, 2018
Objective We describe the characteristics of the 15 patients with fingolimod-associated progressive multifocal leukoencephalopathy (PML) identified from the Novartis data safety base and provide risk estimates for the disorder.
J. Berger, Bruce A. C. Cree, B. Greenberg, B. Hemmer, B. Ward, V. Dong, M. Merschhemke   +6 more
semanticscholar   +1 more source

Germline Genetic Risk Variants for Progressive Multifocal Leukoencephalopathy

Frontiers in Neurology, 2020
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disorder of the brain caused by reactivation of the JC virus (JCV), a polyomavirus that infects at least 60% of the population but is asymptomatic or results in benign symptoms in ...
P. S. Eis, Christopher Donald Bruno, T. Richmond, I. Koralnik, B. Hanson, E. Major, Christina R. Chow, H. Hendel-Chavez, B. Stankoff, J. Gasnault, Y. Taoufik, E. Hatchwell   +11 more
semanticscholar   +1 more source

Tafasitamab as Monotherapy or in Combination in Japanese Patients With B‐Cell Non‐Hodgkin Lymphoma: Results From the Phase 1b J‐MIND Study

Cancer Science, EarlyView.
J‐MIND evaluated the safety and tolerability of tafasitamab, a CD19‐targeting monoclonal antibody, alone or in combination with other therapies in Japanese patients with B‐cell non‐Hodgkin lymphoma (NHL). Most common treatment‐emergent adverse events across all groups were hematological, and no serious tafasitamab treatment‐related or fatal adverse ...
Koji Izutsu, Noriko Fukuhara, Junichiro Yuda, Youko Suehiro, Shigeru Kusumoto, Marie‐Laure Casadebaig, Kazumi Suzukawa, Kentaro Fukushima   +7 more
wiley   +1 more source

Stewardship of Molecular Diagnostics in Transplant Viral Infections

Transplant Infectious Disease, EarlyView.
ABSTRACT The transplant environment requires special considerations when testing for viral infections as immunosuppression results in atypical infection profiles. Microbes otherwise considered commensals or causing mild disease can lead to severe infections in transplant environments. Therefore, guidelines tend to recommend broader microbial testing in
Scott Sugden, David Reynoso, Reema Mathew, Michael Loeffelholz   +3 more
wiley   +1 more source

Progressive Multifocal Leukoencephalopathy Incidence and Risk Stratification Among Natalizumab Users in France.

JAMA Neurology, 2019
Importance Risk of developing progressive multifocal leukoencephalopathy (PML) is the major barrier to using natalizumab for patients with multiple sclerosis (MS). To date, the association of risk stratification with PML incidence has not been evaluated.
S. Vukusic, F. Rollot, R. Casey, J. Pique, R. Marignier, G. Mathey, G. Edan, D. Brassat, A. Ruet, J. de Seze, E. Maillart, H. Zéphir, P. Labauge, N. Derache, C. Lebrun-Frénay, T. Moreau, S. Wiertlewski, E. Berger, X. Moisset, A. Rico-Lamy, B. Stankoff, C. Bensa, E. Thouvenot, O. Heinzlef, A. Al-Khedr, B. Bourre, M. Vaillant, P. Cabre, A. Montcuquet, A. Wahab, J. Camdessanche, A. Tourbah, A. Guennoc, K. Hankiewicz, I. Patry, C. Nifle, N. Maubeuge, C. Labeyrie, P. Vermersch, D. Laplaud   +39 more
semanticscholar   +1 more source

Six‐Year Trends in Real‐World Data Use for Post‐Marketing Surveillance of New Medical Products in Japan

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT The Ministerial Ordinance on Good Post‐Marketing Study Practice for Drugs was amended by the Ministry of Health, Labour and Welfare (MHLW) in 2018 to clearly define post‐marketing database studies (DBS) as a measure of pharmacovigilance activities for approved medical products in Japan.
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Cerebellar Progressive Multifocal Leukoencephalopathy Mimicking Anti-Yo-Antibody-Associated Rapidly Progressive Cerebellar Syndrome

Neurology International, 2023
A 58-year-old woman with a history of systemic lupus erythematosus (SLE) who was taking prednisolone and mycophenolate mofetil presented with gait disturbances that progressively worsened over a period of 3 months. Her blood test and cerebrospinal fluid (
Takayoshi Akimoto, Makoto Hara, Satoshi Hirose, Kazuo Nakamichi, Hideto Nakajima   +4 more
doaj   +1 more source