Results 31 to 40 of about 29,166 (227)

温泉療法による気管支喘息に対する年間薬剤費の削減 [PDF]

, 2004
Costs of drugs used for the treatment for 1 year were compared before and after spa therapy in 16 patients with asthma in relation to disease severity. Asthma severity was classified as : stage 1 (intermittent), 2 (mild persistent), 3(moderate persistent)
Ashida, Kozo, Fujii, Makoto, Hamada, Masanori, Hosaki, Yasuhiro, Iwagaki, Naofumi, Mitsunobu, Fumihiro, Takata, Shingo, Tanizaki, Yoshiro   +7 more
core   +1 more source

n-3系脂肪散を強化した食事療法が有効と考えられた肺気腫の一例 [PDF]

, 1998
An effective treatment for the advanced stages of chronic obstructive pulmonary disease (COPD) has not been established yet. We report our recent experience of one patient with pulmonary emphysema treated by dietary supplementation of n-3 fatty acid for ...
Ashida, Kozo, Hosaki, Yasuhiro, Mifune, Takashi, Mitsunobu, Fumihiro, Okamoto, Makoto, Tanizaki, Yoshiro, Tsugeno, Hirofumi, Tsuji, Takao   +7 more
core   +1 more source

The IRE1α Inhibitor KIRA6 Blocks Leukotriene Biosynthesis in Human Phagocytes

Frontiers in Pharmacology, 2022
The ER stress and Unfolded Protein Response (UPR) component inositol-requiring enzyme 1α (IRE1α) has been linked to inflammation and lipid mediator production.
Xiao Tang, Tarvi Teder, Bengt Samuelsson, Jesper Z. Haeggström   +3 more
doaj   +1 more source

Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases. [PDF]

, 2014
Acanthus mollis (Acanthaceae), Achillea ligustica, Artemisia arborescens and Inula viscosa (Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids.
Amenta, Ammon, Bader, Brand-Williams, Bremner, Bruni, Bruno, Charlier, Dehmlow, DiSepio, Flora, Glaser, Henke, Iversen, Luper, Mosmann, Pannala, Safayhi, Safayhi, Serhan, Spector, Sun, Tornhamre, Tzakou, Voorhees, Wang, Yamamoto   +26 more
core   +1 more source

Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice

Journal of Pharmacological Sciences, 2007
This study investigated endogenous mediators involved in mosquito allergy-associated itching in mice. An intradermal injection of an extract of mosquito salivary gland elicited marked scratching in sensitized mice.
Yasushi Kuraishi, Eiji Ohtsuka, Tasuku Nakano, Sanae Kawai, Tsugunobu Andoh, Hiroshi Nojima, Kiyoshi Kamimura   +6 more
doaj   +1 more source

Validity of serum leukotriene B4 as a marker of decompensated liver cirrhosis in chronic HCV patients: leukotriene B4 in decompensated liver cirrhosis

Egyptian Liver Journal, 2021
Background Liver cirrhosis is divided into two stages: compensated stage and another advanced stage which includes both decompensated cirrhosis and acute-on-chronic liver failure.
Ayman El-Shayeb, Sawsan El-Mallah, Akram Deghady, Samar El-Hewely, Doaa Elwazzan   +4 more
doaj   +1 more source

Effect of montelukast on leukotriene B4 metabolism in asthma

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To observe the effect of montelukast on the expressions of key genes in LTB4 (leukotriene B4) metabolic pathway in treating asthma and investigate the candidate intervene targets of asthma.Methods·The acute, subacute, and chronic asthmatic ...
HU Yu, XIE Liang, ZOU Dan, FU Hongling, LOU Lili, XIE Keqi, LIU Hanmin   +6 more
doaj   +1 more source

Hypercholesterolemia Increases the Production of Leukotriene B4 in Neutrophils by Enhancing the Nuclear Localization of 5-Lipoxygenase

Cellular Physiology and Biochemistry, 2014
Aims: Neutrophils can synthesize leukotriene B4 (LTB4) by activating the 5-lipoxygenase (5-LO)signaling pathway. LTB4 is a pro-inflammatory mediator associated with the etiology and progression of atherosclerosis.
Xiao-Feng Lai, Hua-Di Qin, Lei-Lei Guo, Zi-Guo Luo, Jing Chang, Chun-Chang Qin   +5 more
doaj   +1 more source

Self-Limited versus Delayed Resolution of Acute Inflammation: Temporal Regulation of Pro-Resolving Mediators and MicroRNA [PDF]

, 2012
Mechanisms underlying delays in resolution programs of inflammation are of interest for many diseases. Here, we addressed delayed resolution of inflammation and identified specific microRNA (miR)-metabolipidomic signatures.
Chiang, Nan, Dalli, Jesmond P, Fredman, Gabrielle, Li, Yongsheng, Serhan, Charles Nicholas   +4 more
core   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source