Results 71 to 80 of about 29,166 (227)
The FEBS Journal, EarlyView.Human RNase 7 is known to exert antimicrobial activity in epithelial tissues. Here, using SH‐SY5Y and U‐87 MG, neuroblastoma and glioblastoma cell lines, respectively, we found that RNase 7 enhances immune responses to LPS stimulation by reducing the expression of pro‐inflammatory cytokines, nitric oxide, and ROS.
Rosanna Culurciello +9 more
wiley +1 more source
Endothelial cells can synthesize leukotriene B4 [PDF]
Journal of Vascular Surgery, 1990 Leukotriene B4 (LTB4) from vascular endothelium may play a key role in the genesis of atherosclerotic lesions. However, the ability of this tissue to synthesize LTB4 is controversial. To resolve this issue arachidonic acid metabolism was characterized in cultures of confluent monolayers of a rabbit aortic endothelial cell line by use of both high ...
K D, Nolan +4 more
openaire +2 more sources
Праці Наукового товариства імені Шевченка. Медичні науки, 2019 LEUKOTRIENE B4 AND PROSTAGLANDIN E2 LEVELS IN PATIENTS WITH NSAID-GASTROPATHY AFTER PANTOPRAZOLE ...
K. Kvit +3 more
doaj
The FEBS Journal, EarlyView.Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah +5 more
wiley +1 more source
PPAR Research, 2008 Pancreatic cancer is a devastating disease in which current therapies are inadequate. Separate lines of research have identified the 5-lipoxygenase/leukotriene B4 receptor pathway and the PPAR𝛾 pathway as potential targets for prevention or treatment of ...
Thomas E. Adrian +3 more
doaj +1 more source
Frontiers in Pharmacology, 2020 The pathogenesis of preeclampsia (PE) involves several pathophysiological processes that may be affected by glucocorticoid (GC). We confirmed previously that GC exposure could result in PE, while PE is linked to a deficiency of lipoxin A4 (LXA4), an ...
Haojing Liu +5 more
doaj +1 more source
Leukotriene B4, administered via intracerebroventricular injection, attenuates the antigen-induced asthmatic response in sensitized guinea pigs [PDF]
, 2010 Background Despite intensive studies focused on the pathophysiology of asthmatic inflammation, little is known about how cross-talk between neuroendocrine and immune systems regulates the inflammatory response during an asthmatic attack.
Yi-Liang Zhu +5 more
core +2 more sources
Apremilast in Japanese patients with palmoplantar pustulosis: A randomized, Phase 3 trial
Journal of the European Academy of Dermatology and Venereology, EarlyView.In this Phase 3 trial of Japanese patients with moderate to severe PPP (NCT05174065), significantly more patients achieved PPPASI‐50 at Week 16 with apremilast versus placebo. Patient‐reported outcomes, including pruritus and pain/discomfort, also showed significantly greater decreases at Week 16 with apremilast versus placebo.
Tadashi Terui +15 more
wiley +1 more source
ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid. [PDF]
, 2014 5-Lipoxygenase (5-LOX) reacts with arachidonic acid (AA) to first generate 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid [5(S)-HpETE] and then an epoxide from 5(S)-HpETE to form leukotriene A4, from a single polyunsaturated fatty acid ...
Barbour, Shannon R +4 more
core +2 more sources
Journal of Periodontal Research, EarlyView.This review describes the features of grade C molar‐incisor pattern periodontitis and discusses the role of A. actinomycetemcomitans in its pathogenesis and why molars and incisors are preferably affected. Possible future studies on this aggressive disease in primary and permanent dentition and emerging omics techniques for diagnosis and management are
Luigi Nibali +3 more
wiley +1 more source