Results 21 to 30 of about 12,649 (233)

Combination of Leukotoriene Receptor Antagonist With Antihistamine Has an Additive Suppressive Effect on the Up-regulation of H1-Receptor mRNA in the Nasal Mucosa of Toluene 2,4-Diisocyanate-Sensitized Rat

Journal of Pharmacological Sciences, 2013
.: An attempt was made to clarify the additive suppressive effects of pranlukast, a cysteinyl leukotriene–receptor (LTR) antagonist, in combination with chlorpheniramine, an antihistamine, on the up-regulation of histamine H1–receptor (H1R) mRNA in ...
Wakana Kuroda, Yoshiaki Kitamura, Hiroyuki Mizuguchi, Yuko Miyamoto, Bukasa Kalubi, Hiroyuki Fukui, Noriaki Takeda   +6 more
doaj   +1 more source

Cysteinyl leukotriene-like metabolites are generated in retinal pigment epithelial cells through glutathionylation/reduction of an oxidatively truncated fragment of arachidonate

Results in Chemistry, 2023
γ-Hydroxyalkenals, 4-hydroxynonenal (HNE) and phospholipid esters of 4-hydroxy-8-oxooctenoic acid (HOOA-PL), are produced from the alkyl and carboxyl termini of arachidonyl phospholipids by radical-induced oxidative cleavage. Metabolism of HNE by Michael
Mikhail Linetsky, Anshula Mondal, Si-Yang Liu, Abby M. Hite, Shravani Enduri, Yu-Shiuan Cheng, Beatriz Feijo, Graham Kang, Nana Arhin, Hong Zeng, Olivia R. Laniak, John Denker, Robert G. Salomon   +12 more
doaj   +1 more source

Montelukast Has no Impact on the Systemic Production of TGFβ-1 in Patients with Nasal Polyposis Associated with Aspirin Intolerance

International Archives of Otorhinolaryngology, 2021
Introduction Nasal polyposis is a disease characterized by a mechanical dysfunction of the nasal mucosa, closely related to the unique makeup of its extracellular matrix, which develops as the result of an anomalous tissue remodeling process ...
Rogério Pezato, Luciano Lobato Gregório, Claudina Pérez-Novo, Thiago Ferreira Pinto Bezerra, Eduardo Macoto Kosugi   +4 more
doaj   +1 more source

Inflammatory modulation of the response of bronchial epithelial cells to lipopolysaccharide with pretreatment by montelukast [PDF]

Kragujevac Journal of Science, 2022
Montelukast, a leukotriene receptor antagonist, is the most prescribed nonsteroidal anti-inflammatory drug used as an add-on therapy for asthma. Besides its effect on blocking leukotriene action, montelukast has been proposed to have secondary anti ...
Jendrišek Gorana, Nikolić Aleksandra, Dragičević Sandra   +2 more
doaj   +1 more source

Effect of leukotriene receptor antagonist therapy in bronchial asthma – A prospective, preliminary, hospital-based, randomized study in rural Konaseema, Andhra Pradesh

Indian Journal of Allergy Asthma and Immunology, 2021
BACKGROUND: The role of leukotriene receptor antagonist is well documented in the management of chronic asthma. However, the efficacy in acute asthma is not yet established. AIM AND OBJECTIVES: This study was designed to evaluate the clinical efficacy of
Bhargav Prasad Bathula, Pandit Vinodh Bandela, Pentakota Ravikumar, Bhima Sankar Duvvuri, Subba Rao Polimati   +4 more
doaj   +1 more source

Effect of a leukotriene receptor antagonist on cough receptor sensitivity and allergen-induced cough in a patient with atopic cough variant asthma

Allergology International, 1998
A 24-year-old female patient with chronic dry cough, without wheezing and other symptoms, was diagnosed as atopic cough variant asthma (CVA) sensitized with house dust (HD) mite.
Hideko Kobayashi, Kenji Minoguchi, Yasuro Kohno, Naruhito Oda, Takuya Yokoe, Norio Kihara, Mitsuru Adachi   +6 more
doaj   +1 more source

Synthesis and characterization of critical process related impurities of an asthma drug – Zafirlukast

Journal of Saudi Chemical Society, 2014
Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the treatment of pulmonary disorders such as asthma. During the process development of zafirlukast, eight process related impurities were observed at a level of 0.1–0.15 area percent ...
Gilla Goverdhan, Anumula Raghupathi Reddy, Vurimidi Himabindu, Ghanta Mahesh Reddy   +3 more
doaj   +1 more source

Effect of a leukotriene receptor antagonist pranlukast hydrate, on airway inflammation airway hyperresponsiveness in patients with moderate to severe asthma

Allergology International, 2000
Asthma is characterized by chronic airway inflammation and the recruitment of inflammatory cells, typically eosinophils and lymphocytes, into the airway. Although several chemical mediators are released during the inflammatory process of asthma, evidence
Kiyoko Wada, Kenji Minoguchi, Yasurou Kohno, Naruhito Oda, Takayuki Matsuura, Kenta Kawazu, Masatsugu Kurokawa, Takeshi Tomita, Kana Ueno, Fumio Kokubu, Shunichi Mita, Mitsuru Adachi   +11 more
doaj   +1 more source

Introduction of Leukotriene Receptor Antagonists in Manitoba [PDF]

Canadian Respiratory Journal, 2006
Patient characteristics and prescribing patterns during the introduction of leukotriene receptor antagonists (LTRA) in Manitoba are described using the provincial health database. Residents of Manitoba with asthma, chronic obstructive pulmonary disease, bronchitis or claims for respiratory medications were identified. Six thousand forty‐one of 160,626 (
Macie, C, Wooldrage, K, Manfreda, J, Anthonisen, NR   +3 more
openaire   +4 more sources

Blockade of Leukotriene B4 Signaling Pathway Induces Apoptosis and Suppresses Cell Proliferation in Colon Cancer

Journal of Pharmacological Sciences, 2007
We investigated whether leukotriene B4 (LTB4) and its signaling pathway play an important role in the progression of human colon cancer via a direct stimulation of cancer cell proliferation.
Aya Ihara, Koichiro Wada, Masato Yoneda, Nobutaka Fujisawa, Hirokazu Takahashi, Atsushi Nakajima   +5 more
doaj   +1 more source