Results 41 to 50 of about 354,007 (274)

Synthesis and characterization of critical process related impurities of an asthma drug – Zafirlukast

Journal of Saudi Chemical Society, 2014
Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the treatment of pulmonary disorders such as asthma. During the process development of zafirlukast, eight process related impurities were observed at a level of 0.1–0.15 area percent ...
Gilla Goverdhan, Anumula Raghupathi Reddy, Vurimidi Himabindu, Ghanta Mahesh Reddy   +3 more
doaj   +1 more source

Effect of leukotriene receptor antagonist therapy in bronchial asthma – A prospective, preliminary, hospital-based, randomized study in rural Konaseema, Andhra Pradesh

Indian Journal of Allergy Asthma and Immunology, 2021
BACKGROUND: The role of leukotriene receptor antagonist is well documented in the management of chronic asthma. However, the efficacy in acute asthma is not yet established. AIM AND OBJECTIVES: This study was designed to evaluate the clinical efficacy of
Bhargav Prasad Bathula, Pandit Vinodh Bandela, Pentakota Ravikumar, Bhima Sankar Duvvuri, Subba Rao Polimati   +4 more
doaj   +1 more source

Effect of a leukotriene receptor antagonist pranlukast hydrate, on airway inflammation airway hyperresponsiveness in patients with moderate to severe asthma

Allergology International, 2000
Asthma is characterized by chronic airway inflammation and the recruitment of inflammatory cells, typically eosinophils and lymphocytes, into the airway. Although several chemical mediators are released during the inflammatory process of asthma, evidence
Kiyoko Wada, Kenji Minoguchi, Yasurou Kohno, Naruhito Oda, Takayuki Matsuura, Kenta Kawazu, Masatsugu Kurokawa, Takeshi Tomita, Kana Ueno, Fumio Kokubu, Shunichi Mita, Mitsuru Adachi   +11 more
doaj   +1 more source

Blockade of Leukotriene B4 Signaling Pathway Induces Apoptosis and Suppresses Cell Proliferation in Colon Cancer

Journal of Pharmacological Sciences, 2007
We investigated whether leukotriene B4 (LTB4) and its signaling pathway play an important role in the progression of human colon cancer via a direct stimulation of cancer cell proliferation.
Aya Ihara, Koichiro Wada, Masato Yoneda, Nobutaka Fujisawa, Hirokazu Takahashi, Atsushi Nakajima   +5 more
doaj   +1 more source

Introduction of Leukotriene Receptor Antagonists in Manitoba [PDF]

Canadian Respiratory Journal, 2006
Patient characteristics and prescribing patterns during the introduction of leukotriene receptor antagonists (LTRA) in Manitoba are described using the provincial health database. Residents of Manitoba with asthma, chronic obstructive pulmonary disease, bronchitis or claims for respiratory medications were identified. Six thousand forty‐one of 160,626 (
Macie, C, Wooldrage, K, Manfreda, J, Anthonisen, NR   +3 more
openaire   +4 more sources

Structure based virtual screening of ligands to identify cysteinyl leukotriene receptor 1 antagonist

Bioinformation, 2014
Montelukast and Zafirlukast are known leukotriene receptor antagonists prescribed in asthma treatment. However, these fall short as mono therapy and are frequently used in combination with inhaled glucocorticosteroids with or without long acting beta 2 ...
S. Bandaru, Vijaya Kumar Marri, Priyadarshani Kasera, Purnima Kovuri, A. Girdhar, Deepti Mittal, Sabeen Ikram, Ravi Gv, Anuraj Nayarisseri   +8 more
semanticscholar   +1 more source

Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs

Science Advances, 2019
Two distinct antagonist-bound structures of CysLT1R reveal unique ligand-binding modes and signaling mechanisms. The G protein–coupled cysteinyl leukotriene receptor CysLT1R mediates inflammatory processes and plays a major role in numerous disorders ...
A. Luginina, A. Gusach, E. Marin, A. Mishin, R. Brouillette, P. Popov, A. Shiriaeva, É. Besserer-Offroy, J. Longpré, E. Lyapina, A. Ishchenko, N. Patel, V. Polovinkin, Nadezhda Safronova, A. Bogorodskiy, E. Edelweiss, Hao Hu, U. Weierstall, Wei Liu, A. Batyuk, V. Gordeliy, G. Han, P. Sarret, V. Katritch, V. Borshchevskiy, V. Cherezov   +25 more
semanticscholar   +1 more source

Drug fever—an immune-mediated delayed type hypersensitivity reaction to Vinca alkaloids in pediatric oncology patients, possibly mediated by cysteinyl leukotrienes

Frontiers in Allergy
BackgroundDrug hypersensitivity reactions are common in pediatric hemato-oncology patients due to multiple factors including immune compromise and pharmacological complexities. Fever can signify severe delayed-type hypersensitivity reactions such as drug
Mona I. Kidon, Mona I. Kidon, Mona I. Kidon, Soad Haj Yahia, Soad Haj Yahia, Soad Haj Yahia, Gadi Abebe-Campino, Gadi Abebe-Campino, Nancy Agmon-Levin, Nancy Agmon-Levin, Nancy Agmon-Levin, Michal Yelon, Michal Yelon   +12 more
doaj   +1 more source

Leukotriene D4 Stimulates the Migration but Not Proliferation of Endothelial Cells Mediated by the Cysteinyl Leukotriene CysLT1 Receptor via the Extracellular Signal-Regulated Kinase Pathway

Journal of Pharmacological Sciences, 2009
The actions of cysteinyl leukotrienes (CysLTs) are mediated by activating CysLT receptors, CysLT1, and CysLT2. The CysLT1 receptor mediates vascular responses to CysLTs; however, its effect on the proliferation and migration of endothelial cells is not ...
Yu-Mei Yuan, San-Hua Fang, Xiao-Dong Qian, Li-Ying Liu, Li-Hua Xu, Wen-Zhen Shi, Li-Hui Zhang, Yun-Bi Lu, Wei-Ping Zhang, Er-Qing Wei   +9 more
doaj   +1 more source

Leukotriene Receptor Antagonists and Related Compounds [PDF]

Canadian Respiratory Journal, 1999
Leukotrienes (LTs), lipid mediators of inflammation, have proved to be important biochemicals involved in the symptoms and physiological changes of asthma. In the past year and a half, the development of three new drugs that modulate the LT pathway has been completed.
openaire   +3 more sources